Cited by 129Neurobiology and Insect Physiology ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Fasting Launches CRTC to Facilitate Long-Term Memory Formation in Drosophila

Hirano, Yukinori, Masuda, Tomoko, Naganos, Shintaro, Matsuno, Motomi, Ueno, Kohei, Miyashita, Tomoyuki, Horiuchi, Junjiro, Saitoe, Minoru·2013·Science

Abstract

Canonical aversive long-term memory (LTM) formation in Drosophila requires multiple spaced trainings, whereas appetitive LTM can be formed after a single training. Appetitive LTM requires fasting prior to training, which increases motivation for food intake. However, we found that fasting facilitated LTM formation in general; aversive LTM formation also occurred after single-cycle training when mild fasting was applied before training. Both fasting-dependent LTM (fLTM) and spaced training-dependent LTM (spLTM) required protein synthesis and cyclic adenosine monophosphate response element-binding protein (CREB) activity. However, spLTM required CREB activity in two neural populations--mushroom body and DAL neurons--whereas fLTM required CREB activity only in mushroom body neurons. fLTM uses the CREB coactivator CRTC, whereas spLTM uses the coactivator CBP. Thus, flies use distinct LTM machinery depending on their hunger state.

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Crossref · 10.1126/science.1227170

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  • Fasting facilitates long-term memory formation in Drosophila melanogaster.

    “In line with these observations, it has been demonstrated that fasting facilitates long-term memory formation in Drosophila melanogaster (Hirano et al., 2013).”

    From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Hirano et al., 2013

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Authors
Hirano, Y., Masuda, T., Naganos, S., Matsuno, M., Ueno, K., Miyashita, T., Horiuchi, J., & Saitoe, M.
Affiliations
  • Japan Science and Technology Agency (JP)
  • Tokyo Metropolitan Institute of Medical Science (JP)
  • Tokyo Metropolitan University (JP)
Corresponding author
  • Hirano, Yukinori
  • Saitoe, Minoru
Venue
Science
Published
2013-01-25
Volume
339
Issue
6118
Pages
443-446
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2000932526
Cited by
129
References
36
Citations by year
2026: 6 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 11 · 2018: 13 · 2017: 12 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 10
FWCI
6.53
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
Japan Society for the Promotion of Science (24700415, 23650198)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
fasting, long-term memory, aversive memory, appetitive memory, spaced training, CREB, CRTC, CBP, mushroom body, protein synthesis, hunger, Drosophila
MeSH terms
Animals, Cycloheximide, Drosophila, Fasting, Neurons, Protein Synthesis Inhibitors, Transcription Factors, Cyclic AMP Response Element-Binding Protein, Mushroom Bodies, Drosophila Proteins, CREB-Binding Protein, Memory, Long-Term

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