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Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

Yousefi, O Sascha, Günther, Matthias, Hörner, Maximilian, Chalupsky, Julia, Wess, Maximilian, Brandl, Simon M, Smith, Robert W, Fleck, Christian, Kunkel, Tim, Zurbriggen, Matias D, Höfer, Thomas, Weber, Wilfried, Schamel, Wolfgang WA·2019·eLife

DOI 10.7554/elife.42475

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Abstract

The immune system distinguishes between self and foreign antigens. The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the different ligand binding half-lives to the T cell receptor (TCR). It is challenging to test KPR as the available experimental systems fall short of only altering the binding half-lives and keeping other parameters of the interaction unchanged. We engineered an optogenetic system using the plant photoreceptor phytochrome B (PhyB) as a ligand to selectively control the dynamics of ligand binding to the TCR by light. This opto-ligand-TCR system was combined with the unique property of PhyB to continuously cycle between the binding and non-binding states under red light, with the light intensity determining the cycling rate and thus the binding duration. Mathematical modeling of our experimental datasets showed that indeed the ligand-TCR interaction half-life is the decisive factor for activating downstream TCR signaling, substantiating KPR.

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Correction for Ling et al., Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
(2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600151113 · Cited by 6

Authors: Yousefi, O. S., Günther, M., Hörner, M., Chalupsky, J., Wess, M., Brandl, S. M., Smith, R. W., Fleck, C., Kunkel, T., Zurbriggen, M. D., Höfer, T., Weber, W., & Schamel, W. W.
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2019-04-05
Volume: 8
ISSN: 2050-084X
DOI: 10.7554/elife.42475
Cited by: 117
References: 88
Language: en
Licence: creativecommons.org/licenses/by/4.0/ (vor)
creativecommons.org/licenses/by/4.0/ (am)
creativecommons.org/licenses/by/4.0/ (tdm)
Funders: Deutsche Forschungsgemeinschaft (EXC2189, GSC-4, EXC294, EXC81, INST 39/899-1 FUGG)

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

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