The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TCR Signaling: Mechanisms of Initiation and Propagation
Open accessAbstract
The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and harnessing T cells therapeutically. A hallmark of the T cell response is the ability of T cells to quantitatively respond to antigenic ligands derived from pathogens while remaining inert to similar ligands derived from host tissues. Recent studies have revealed exciting properties of the TCR and behaviors of its signaling effectors that are used to detect and discriminate between antigens. Here we highlight these recent findings, focusing on the proximal TCR signaling molecules Zap70, Lck and LAT, to provide mechanistic models and insights into the exquisite sensitivity and specificity of the TCR.
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Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Structure and regulation of Src family kinases
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Digital signaling and hysteresis characterize Ras activation in lymphoid cells.
Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A. K., & Roose, J. P. (2009) · Cell · doi:10.1016/j.cell.2008.11.051 · Cited by 398 · cited 2×
“MEK, and ultimately the MAP kinase ERK [9].”
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Cited by
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Hwang, J.-R., Byeon, Y., Kim, D., & Park, S.-G. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0435-8 · Cited by 470
The intrinsic substrate specificity of the human tyrosine kinome
Yaron-Barir, T. M., Joughin, B. A., Huntsman, E. M., Kerelsky, A., Cizin, D. M., Cohen, B. M., Regev, A., Song, J., Vasan, N., Lin, T.-Y., et al. (2024) · Nature · doi:10.1038/s41586-024-07407-y · Cited by 189
CD45 functions as a signaling gatekeeper in T cells
Courtney, A. H., Shvets, A. A., Lu, W., Griffante, G., Mollenauer, M., Horkova, V., Lo, W.-L., Yu, S., Stepanek, O., Chakraborty, A. K., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw8151 · Cited by 161
Self-citationOptogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
Yousefi, O. S., Günther, M., Hörner, M., Chalupsky, J., Wess, M., Brandl, S. M., Smith, R. W., Fleck, C., Kunkel, T., Zurbriggen, M. D., et al. (2019) · eLife · doi:10.7554/elife.42475 · Cited by 117
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells
Tanaka, A., Nishikawa, H., Noguchi, S., Sugiyama, D., Morikawa, H., Takeuchi, Y., Ha, D., Shigeta, N., Kitawaki, T., Maeda, Y., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191009 · Cited by 96
Metadata
- Authors
- Courtney, A. H., Lo, W.-L., & Weiss, A.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 43
- Issue
- 2
- Pages
- 108-123
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2777469091
- Cited by
- 571
- References
- 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Courtney, A. H., Lo, W.-L., & Weiss, A. (2018). TCR Signaling: Mechanisms of Initiation and Propagation. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2017.11.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
