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Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants
Open accessAbstract
Mitochondrial complex III (CIII 2 ) and complex IV (CIV), which can associate into a higher-order supercomplex (SC III 2 +IV), play key roles in respiration. However, structures of these plant complexes remain unknown. We present atomic models of CIII 2 , CIV, and SC III 2 +IV from Vigna radiata determined by single-particle cryoEM. The structures reveal plant-specific differences in the MPP domain of CIII 2 and define the subunit composition of CIV. Conformational heterogeneity analysis of CIII 2 revealed long-range, coordinated movements across the complex, as well as the motion of CIII 2 ’s iron-sulfur head domain. The CIV structure suggests that, in plants, proton translocation does not occur via the H channel. The supercomplex interface differs significantly from that in yeast and bacteria in its interacting subunits, angle of approach and limited interactions in the mitochondrial matrix. These structures challenge long-standing assumptions about the plant complexes and generate new mechanistic hypotheses.
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Metadata
- Authors
- Maldonado, M., Guo, F., & Letts, J. A.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-01-19
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W3125247928
- Cited by
- 834
- References
- 3
- FWCI
- 41.06
- Type
- journal article
- Language
- en
- Open access
- gold
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