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Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis

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Schapiro, Kyra, Rittenberg, JD, Kenngott, Max, Marder, Eve·2024·eLife
DOI 10.7554/elife.98844.3PMC PMC11479588

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Abstract

Motor systems operate over a range of frequencies and relative timing (phase). We studied the role of the hyperpolarization-activated inward current (I h ) in regulating these features in the pyloric rhythm of the stomatogastric ganglion (STG) of the crab, Cancer borealis, as temperature was altered from 11°C to 21°C. Under control conditions, rhythm frequency increased monotonically with temperature, while the phases of the pyloric dilator (PD), lateral pyloric (LP), and pyloric (PY) neurons remained constant. Blocking I h with cesium (Cs + ) phase advanced PD offset, LP onset, and LP offset at 11°C, and the latter two further advanced as temperature increased. In Cs + the frequency increase with temperature diminished and the Q 10 of the frequency dropped from ~1.75 to ~1.35. Unexpectedly in Cs + , the frequency dynamics became non-monotonic during temperature transitions; frequency initially dropped as temperature increased, then rose once temperature stabilized, creating a characteristic ‘jag’. Interestingly, these jags persisted during temperature transitions in Cs + when the pacemaker was isolated by picrotoxin, although the temperature-induced change in frequency recovered to control levels. Overall, these data suggest that I h plays an important role in maintaining smooth transitory responses and persistent frequency increases by different mechanisms in the pyloric circuitry during temperature fluctuations.

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  • Many biological processes vary considerably over 4-5 °C, well within the range of what is normally considered room temperature.

    “because many biological processes vary considerably over 4-5 • C [40,55-59], well within the range of what is normally considered room temperature.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [59]

    The Results report that pyloric rhythm frequency increased with temperature, and the Temperature protocol describes measurements in 2°C steps from 11°C to 21°C (page not specified in our copy). This supports temperature sensitivity in one biological process, but not the broader claim about many processes or the characterization of a 4–5°C change as within room temperature. (LLM, conf=0.83)

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Authors
Schapiro, K., Rittenberg, J., Kenngott, M., & Marder, E.
Affiliations
Brandeis University (US)
Corresponding author
Schapiro, Kyra
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2024-10-15
Volume
13
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.98844.3
PMC
PMC11479588
OpenAlex
W4403430281
Cited by
8
References
0
Citations by year
2026: 7 · 2025: 1
Type
posted content
Language
en
Open access
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Locations
  • eLife (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (T32NS007292, R35NS097343)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hyperpolarization-activated current, pyloric rhythm, stomatogastric ganglion, Cancer borealis, temperature effects, cesium block, pyloric dilator neuron, lateral pyloric neuron, cardiac pacemaker, Q10, time-scale separation, crustacean motor control

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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