Exploring the Potential of Deep Eutectic Solvents (DES) in Bioactive Natural Product Research: From DES to NaDES, THEDES, and Beyond
Open accessAbstract
Background: Deep eutectic solvents (DESs) have garnered significant interest in natural products research, owing to their green and natural attributes in comparison to conventional solvents. However, the approach of demonstrating that DESs are superior extractants has led to an underestimation of their full potential in this field. This perspective disregards crucial challenges related to their practical application and potential scalability, mainly the difficulty of target component separation from intermolecular network forming by DESs. Conversely, the DESs unique features can enhance aspects such as solubilization, stabilization, and storage of natural products, as well as improve their biological activities. By addressing key challenges and limitations, we aim to provide valuable insights into the potential of DESs in this domain. Methodology: In this review, we conducted an exhaustive literature search to gather relevant articles about DESs and their applications in bioactive natural product research. The gathered literature was analyzed, and a systematic thematic categorization was performed, emphasizing studies where the use of DESs yielded relevant outcomes that could potentially present an advantage in the exploration of bioactive natural products. The approach in structuring this review aimed to provide an overview of the potential and challenges associated with DESs in the domain of bioactive natural product research, transcending their conventional role as mere extraction solvents. Results: Through this critical analysis of the literature, this review delves into the potential of DESs as effective solvents for the solubilization, stabilization, and storage of bioactive natural products. In addition, it highlights the ability of DESs to improve the biological activities of natural products, as well as to be used as formulation media for the transport of pharmaceutical active ingredients. By revealing these advances, the review contributes to a more complete understanding of DESs and its applicability in the field of bioactive natural products research. Conclusions: The studies compiled in this review underscore the expanded potential of DESs, beyond extraction, finding relevance in the realm of natural products research. Notably, they contribute to enhancing the desired attributes of the final product, signifying a promising avenue for future advancements in this field.
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DESs' low vapor pressure, non-flammability, and biodegradability make them particularly attractive for environmentally sustainable extraction processes.
“In addition, their low vapor pressure, non-flammability, and biodegradability make them particularly attractive for environmentally sustainable extraction processes [25].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [25]
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Alahmadi, S. M., & Abu-Dief, A. M. (2026) · Sustainable Chemistry · doi:10.3390/suschem7030033 · Cited by 1 · see citing works
“In addition, their low vapor pressure, non-flammability, and biodegradability make them particularly attractive for environmentally sustainable extraction processes [25].”
- Authors
- Ruesgas Ramon, M., Durand, E., Garcia-Sosa, K., & Peña-Rodríguez, L. M.
- Affiliations
- Biotechnology Unit, Centro de Investigación Cientifíca de Yucatán, Mérida, Yucatán, México
- Centre de Coopération Internationale en Recherche Agronomique pour le Développement (FR)
- Venue
- PeerJ Analytical Chemistry
- Publisher
- PeerJ
- Published
- 2023-12-08
- Volume
- 5
- Pages
- e28
- ISSN
- 2691-6630 (ISSN-L)
- OpenAlex
- W4389486572
- Cited by
- 21
- References
- 86
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- PeerJ Analytical Chemistry (publishedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Agritrop (Cirad) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The National Council for Science and Technology
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Physical Sciences › Chemical Engineering › Filtration and Separation › Chemical and Physical Properties in Aqueous Solutions
- Keywords
- deep eutectic solvents, bioactive natural products, natural product extraction, solubilization, biological activity enhancement, drug delivery, green solvents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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