Application of Deep Eutectic Solvents (DES) for Phenolic Compounds Extraction: Overview, Challenges, and Opportunities
Abstract
The green chemistry era has pushed the scientific community to investigate and implement new solvents in phenolic compounds (PC) extraction as alternatives to organic solvents, which are toxic and may be dangerous. Recently, deep eutectic solvents (DES) have been applied as extraction solvents for PC. They have the advantages of biodegradability and ease of handling with very low toxicity. Nevertheless, the extraction process is affected by several factors: affinity between DES and the target compounds, the water content, the mole ratio between DES' starting molecules, the liquid/solid ratio between the DES and sample, and the conditions and extraction method. On the other hand, PC recovery from DES is a challenge because they can establish a strong hydrogen bond network. Alternatively, another possibility is to use DES as solvent extraction as well as formulation medium. In this way, DES can be suitable for cosmetics, pharmaceutical, or food applications.
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DESs have been used as delignification agents owing to their ability to dissolve phenolic compounds.
“owing to the already well-known ability of DESs to dissolve phenolic compounds [29], DESs have been used as delignification agents [30].”
From Deep eutectic solvents: overcoming 21st century challenges (2019) · cites this paper as [29]
DESs with hydrophobic nature, low viscosity, and bearing kosmotropic anions or chaotropic cations enhance the activities and stabilities of enzymes.
“Commonly, DESs with hydrophobic nature, with low viscosity, and bearing kosmotropic anions or chaotropic cations enhance the activities and stabilities of enzymes [29,30].”
From Deep eutectic solvents: overcoming 21st century challenges (2019) · cites this paper as [29]
Reactions involving lipase, protease, and cellulase in DESs illustrate enhanced activity and stability.
“Reactions provided in literature where hydrolysis, transesterification, esterification, and alcoholysis involving lipase, protease, and cellulase illustrate well this enhanced activity and stability [29,31,32].”
From Deep eutectic solvents: overcoming 21st century challenges (2019) · cites this paper as [29]
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Self-citation
- Authors
- Ruesgas-Ramón, M., Figueroa-Espinoza, M. C., & Durand, E.
- Affiliations
- Montpellier SupAgro, UMR 1208 IATE, Montpellier F-34060, France
- Centre de Coopération Internationale en Recherche Agronomique pour le Développement (FR)
- Corresponding author
- Durand, Erwann
- ORCID
- Durand, Erwann
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-04-26
- Volume
- 65
- Issue
- 18
- Pages
- 3591-3601
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2605998787
- Cited by
- 790
- References
- 14
- Citations by year
- 2026: 76 · 2025: 104 · 2024: 113 · 2023: 110 · 2022: 104 · 2021: 80 · 2020: 93 · 2019: 70 · 2018: 33 · 2017: 7
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Agritrop (Cirad) (submittedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología (405131)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- deep eutectic solvents, phenolic compounds, green solvents, solvent extraction, hydrogen bonding, extraction conditions, biodegradable solvents, solvent toxicity
- MeSH terms
- Chemical Fractionation, Phenols, Plant Extracts, Plants
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