Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment
Open accessAbstract
Many studies have demonstrated the impact of intestinal microbiota on normal brain development. Moreover, the gut microbiota (GM) is impacted by multiple endogenous and environmental factors that may promote gut dysbiosis (GD). An increasing number of studies are investigating the possible role of the GD in the development of neurological and behavioral disorders. For autism spectrum disorders (ASD), specific intestinal bacterial signatures have been identified, knowing that gastrointestinal symptoms are frequently found in ASD. In this review, the peri and post-natal factors modulating the GM are described and the specific gut bacterial signature of ASD children is detailed. Through bidirectional communication between the GM and the brain, several mechanisms are involved in the development of ASD, such as cytokine-mediated neuroinflammation and decreased production of neuroprotective factors such as short-chain fatty acids by the GM. Imbalance of certain neurotransmitters such as serotonin or gamma-aminobutyric acid could also play a role in these gut-brain interactions. Some studies show that this GD in ASD is partly reversible by treatment with pre- and probiotics, or fecal microbiota transplantation with promising results. However, certain limitations have been raised, in particular concerning the short duration of treatment, the small sample sizes and the diversity of protocols. The development of standardized therapeutics acting on GD in large cohort could rescue the gastrointestinal symptoms and behavioral impairments, as well as patient management.
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Certain bacterial strains, including Lactobacillus and Bifidobacterium, modulate the production of neurotransmitters such as GABA.
“Furthermore, certain bacterial strains, including Lactobacillus and Bifidobacterium, have been observed to modulate the production of neurotransmitters such as GABA [94].”
From The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders (2025) · cites this paper as [94]
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The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
Młynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kopeć, K., Wasiak, J., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17071135 · Cited by 44 · see citing works
- Authors
- Poupard, L., Page, G., Thoreau, V., & Kaouah, Z.
- Affiliations
- Université de Poitiers (FR)
- Corresponding author
- Poupard, Lisa
- Venue
- Clinical Psychopharmacology and Neuroscience
- Published
- 2024-07-25
- Volume
- 22
- Issue
- 4
- Pages
- 554-564
- ISSN
- 1738-1088 (ISSN-L)
- 2093-4327
- PMC
- PMC11494427
- OpenAlex
- W4400994298
- Cited by
- 6
- References
- 78
- Citations by year
- 2026: 2 · 2025: 4
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Clinical Psychopharmacology and Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, autism spectrum disorder, gut dysbiosis, gut-brain axis, neuroinflammation, short-chain fatty acids, serotonin, GABA, prebiotics, probiotics, fecal microbiota transplantation, gastrointestinal symptoms, microbiota-based therapy
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