A review of probiotics in the treatment of autism spectrum disorders: Perspectives from the gut–brain axis

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Vos, T., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32154-2 · Cited by 13,220 · see citing works

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works

Gut feelings: the emerging biology of gut-brain communication

Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Byndloss, M. X., Olsan, E. E., Rivera-Chávez, F., Tiffany, C. R., Cevallos, S. A., Lokken, K. L., Torres, T. P., Byndloss, A. J., Faber, F., Gao, Y., et al. (2017) · Science · doi:10.1126/science.aam9949 · Cited by 1,237 · see citing works

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182 · see citing works

Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring

Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163 · see citing works

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works

New evidences on the altered gut microbiota in autism spectrum disorders

Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040 · see citing works

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

Nelson, S. B., & Valakh, V. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.033 · Cited by 1,001 · see citing works

Pyrosequencing study of fecal microflora of autistic and control children

Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977 · see citing works

Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children

Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940 · see citing works

Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter

Owens, M. J., & Nemeroff, C. B. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.288 · Cited by 934 · see citing works

Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified

De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D. I., Cristofori, F., Guerzoni, M. E., Gobbetti, M., & Francavilla, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076993 · Cited by 887 · see citing works

Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder

Sgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.018 · Cited by 865 · see citing works

Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008.

(2012) · PubMed · Cited by 852 · see citing works

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis

McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014) · Pediatrics · doi:10.1542/peds.2013-3995 · Cited by 831 · cited 1× · see citing works

Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children

Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784 · see citing works

Toxigenic clostridia

Hatheway, C. L. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.66 · Cited by 648 · see citing works

Gastrointestinal microbiota in children with autism in Slovakia

Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632 · see citing works

Vagal pathways for microbiome-brain-gut axis communication

Forsythe, P., Bienenstock, J., & Kunze, W. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_5 · Cited by 576 · see citing works

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis

Mcfarland, L. V., Evans, C., & Goldstein, E. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00124 · Cited by 569 · see citing works

Gut microbiota-brain axis

Wang, H.-X., & Wang, Y.-P. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.190667 · Cited by 546 · see citing works

Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development

Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1973-x · Cited by 528 · see citing works

Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., Bennett, A., Jabado, O., Hirschberg, D. L., & Lipkin, W. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024585 · Cited by 492 · see citing works

Oxytocin in general anxiety and social fear: a translational approach

Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468 · see citing works

The Gut Microbiota and Autism Spectrum Disorders

Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

Liu, S., Li, E., Sun, Z., Fu, D., Duan, G., Jiang, M., Yu, Y., Mei, L., Yang, P., Tang, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36430-z · Cited by 457 · see citing works

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children

Zhang, C., Yin, A., Li, H., Wang, R., Wu, G. G., Shen, J., Zhang, M. H., Wang, L., Hou, Y., OuYang, H., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.007 · Cited by 416 · see citing works

Meta-analysis of probiotics for the prevention of traveler's diarrhea

McFarland, L. V. (2005) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2005.10.003 · Cited by 412 · see citing works

Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder

Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412 · see citing works

The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder

Srikantha, P., & Mohajeri, M. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092115 · Cited by 400 · see citing works

The role of probiotics in children with autism spectrum disorder: A prospective, open-label study

Shaaban, S. Y., El Gendy, Y. G., Mehanna, N. S., El-Senousy, W. M., El-Feki, H. S. A., Saad, K., & El-Asheer, O. M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1347746 · Cited by 374 · see citing works

The role of inflammation in irritable bowel syndrome (IBS)

Ng, Q. X., Soh, A. Y. S., Loke, W., Lim, D. Y., & Yeo, W. S. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s174982 · Cited by 360 · see citing works

A meta-analysis of the use of probiotics to alleviate depressive symptoms

Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W.-S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.063 · Cited by 357 · see citing works

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., Loth, E., McAlonan, G. M., McCracken, J. T., Parr, J. R., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117741766 · Cited by 342 · see citing works

Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors

Gorrindo, P., Williams, K. C., Lee, E. B., Walker, L. S., McGrew, S. G., & Levitt, P. (2012) · Autism Research · doi:10.1002/aur.237 · Cited by 325 · see citing works

Oxidative Stress in Autism Spectrum Disorder

Bjørklund, G., Meguid, N. A., El-Bana, M. A., Tinkov, A. A., Saad, K., Dadar, M., Hemimi, M., Skalny, A. V., Hosnedlová, B., Kizek, R., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01742-2 · Cited by 323 · see citing works

Neurochemical correlates of autistic disorder: a review of the literature

Lam, K. S. L., Aman, M. G., & Arnold, L. E. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2005.03.003 · Cited by 318 · see citing works

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Foss‐Feig, J. H., Adkinson, B. D., Ji, J. L., Yang, G., Srihari, V. H., McPartland, J. C., Krystal, J. H., Murray, J. D., & Anticevic, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.005 · Cited by 310 · see citing works

Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder

Luna, R. A., Oezguen, N., Balderas, M., Venkatachalam, A., Runge, J. K., Versalovic, J., Veenstra-VanderWeele, J., Anderson, G. M., Savidge, T., & Williams, K. C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.11.008 · Cited by 295 · see citing works

The impact of gut microbiota on brain and behaviour

Dinan, T. G., & Cryan, J. F. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000221 · Cited by 267 · see citing works

The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder

Li, Q., & Zhou, J.-M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.013 · Cited by 253 · see citing works

Gastrointestinal symptoms in a sample of children with pervasive developmental disorders

Nikolov, R. N., Bearss, K. E., Lettinga, J., Erickson, C., Rodowski, M., Aman, M. G., McCracken, J. T., McDougle, C. J., Tierney, E., Vitiello, B., et al. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0637-8 · Cited by 240 · see citing works

Gut microbiota and autism: key concepts and findings

Ding, H. T., Taur, Y., & Walkup, J. T. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2960-9 · Cited by 232 · see citing works

The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders

Hughes, H. K., Rose, D., & Ashwood, P. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0887-6 · Cited by 225 · see citing works

The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

Maqsood, R., & Stone, T. W. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2039-1 · Cited by 223 · see citing works

Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders

Tabouy, L., Getselter, D., Ziv, O., Karpuj, M., Tabouy, T., Lukic, I., Maayouf, R., Werbner, N., Ben-Amram, H., Nuriel-Ohayon, M., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.05.015 · Cited by 214 · see citing works

Gastrointestinal issues in autism spectrum disorder

Hsiao, E. Y. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000029 · Cited by 209 · see citing works

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 203 · see citing works

Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism

Karvat, G., & Kimchi, T. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.274 · Cited by 203 · see citing works

The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders

Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-153 · Cited by 200 · see citing works

Effects of Probiotic Supplementation on Gastrointestinal, Sensory and Core Symptoms in Autism Spectrum Disorders: A Randomized Controlled Trial

Santocchi, E., Guiducci, L., Prosperi, M., Calderoni, S., Gaggini, M., Apicella, F., Tancredi, R., Billeci, L., Mastromarino, P., Grossi, E., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.550593 · Cited by 198 · see citing works

Altered Gut Microbiota in Chinese Children With Autism Spectrum Disorders

Ma, B., Liang, J., Dai, M., Wang, J., Luo, J., Zhang, Z., & Jing, J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00040 · Cited by 197 · see citing works

The role of oxidative damage in the neuropathology of organic acidurias: Insights from animal studies

Wajner, M., Latini, A., Wyse, Â. T. D. S., & Dutra‐Filho, C. S. (2004) · Journal of Inherited Metabolic Disease · doi:10.1023/b:boli.0000037353.13085.e2 · Cited by 191 · see citing works

Alteration of Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism

Shimmura, C., Suda, S., Tsuchiya, K. J., Hashimoto, K., Ohno, K., Matsuzaki, H., Iwata, K., Matsumoto, K., Wakuda, T., Kameno, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025340 · Cited by 189 · see citing works

The level of arabinitol in autistic children after probiotic therapy

Kałużna-Czaplińska, J., & Błaszczyk, S. (2012) · Nutrition · doi:10.1016/j.nut.2011.08.002 · Cited by 189 · see citing works

Urinary p-cresol in autism spectrum disorder

Persico, A. M., & Napolioni, V. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.09.002 · Cited by 189 · see citing works

Intestinal Dysbiosis and Yeast Isolation in Stool of Subjects with Autism Spectrum Disorders

Iovene, M. R., Bombace, F., Maresca, R., Sapone, A., Iardino, P., Picardi, A., Marotta, R., Schiraldi, C., Siniscalco, D., Serra, N., et al. (2017) · Mycopathologia · doi:10.1007/s11046-016-0068-6 · Cited by 184 · see citing works

Role of probiotics in the prevention of the enteric colonization by Candida in preterm newborns: incidence of late-onset sepsis and neurological outcome

Romeo, M. G., Romeo, D. M., Trovato, L., Oliveri, S. M., Palermo, F., Cota, F., & Betta, P. (2010) · Journal of Perinatology · doi:10.1038/jp.2010.57 · Cited by 183 · see citing works

Probiotics in The Treatment of Irritable Bowel Syndrome

Saggioro, A. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000129271.98814.e2 · Cited by 176 · see citing works

The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders

Critchfield, J. W., van Hemert, S., Ash, M. E., Mulder, L. H. C., & Ashwood, P. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/161358 · Cited by 175 · see citing works

A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders.

Parracho, H. M. R. T., Gibson, G. R., Knott, F., Bosscher, D., Kleerebezem, M., & McCartney, A. L. (2010) · International Journal of Probiotics and Prebiotics · Cited by 162 · see citing works

Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of <i>Clostridia</i> spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia

Shaw, W. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460763968 · Cited by 162 · see citing works

Urinary <i>p</i>-cresol is elevated in small children with severe autism spectrum disorder

Altieri, L., Neri, C., Sacco, R., Curatolo, P., Benvenuto, A., Muratori, F., Santocchi, E., Bravaccio, C., Lenti, C., Saccani, M., et al. (2011) · Biomarkers · doi:10.3109/1354750x.2010.548010 · Cited by 161 · see citing works

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Tejeda, H. A., Shippenberg, T. S., & Henriksson, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0844-x · Cited by 155 · see citing works

Can probiotics benefit children with autism spectrum disorders?

Navarro, F., Liu, Y., & Rhoads, J. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10093 · Cited by 154 · see citing works

Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial

Kong, X.-J., Liu, J., Liu, K., Koh, M., Sherman, H., Liu, S., Tian, R., Sukijthamapan, P., Wang, J., Fong, M., et al. (2021) · Nutrients · doi:10.3390/nu13051552 · Cited by 150 · see citing works

Oscillatory synchrony and human visual cognition

Tallon‐Baudry, C. (2003) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2003.09.009 · Cited by 145 · see citing works

New and Preliminary Evidence on Altered Oral and Gut Microbiota in Individuals with Autism Spectrum Disorder (ASD): Implications for ASD Diagnosis and Subtyping Based on Microbial Biomarkers

Kong, X., Liu, J., Çetinbaş, M., Sadreyev, R. I., Koh, M., Huang, H. Y., Adeseye, A., He, P., Zhu, J., Russell, H., et al. (2019) · Nutrients · doi:10.3390/nu11092128 · Cited by 145 · see citing works

Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation?

Cammarota, G., Ianiro, G., Bibbò, S., & Gasbarrini, A. (2014) · Internal and Emergency Medicine · doi:10.1007/s11739-014-1069-4 · Cited by 136 · see citing works

Brief report: association between behavioral features and gastrointestinal problems among children with autism spectrum disorder

Maenner, M. J., Arneson, C. L., Levy, S. E., Kirby, R. S., Nicholas, J. S., & Durkin, M. S. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1379-6 · Cited by 122 · see citing works

Gut Microbiota, Inflammation, and Probiotics on Neural Development in Autism Spectrum Disorder

Doenyas, C. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.060 · Cited by 121 · see citing works

Current nutritional approaches in managing autism spectrum disorder: A review

Çekici, H., & Şanlıer, N. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1358481 · Cited by 119 · see citing works

Prefrontal nicotinic receptors control novel social interaction between mice

Avale, M. E., Chabout, J., Pons, S., Serreau, P., De Chaumont, F., Olivo‐Marin, J., Bourgeois, J., Maskos, U., Changeux, J., & Granon, S. (2011) · The FASEB Journal · doi:10.1096/fj.10-178558 · Cited by 114 · see citing works

Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics

Grossi, E., Melli, S., Dunca, D., & Terruzzi, V. (2016) · SAGE Open Medical Case Reports · doi:10.1177/2050313x16666231 · Cited by 113 · see citing works

Oral probiotic administration during pregnancy prevents autism‐related behaviors in offspring induced by maternal immune activation via anti‐inflammation in mice

Wang, X., Yang, J., Zhang, H., Yu, J., & Yao, Z. (2019) · Autism Research · doi:10.1002/aur.2079 · Cited by 107 · see citing works

Identification and treatment of pathophysiological comorbidities of autism spectrum disorder to achieve optimal outcomes

Frye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96 · see citing works

Characterization of Intestinal Microbiota and Probiotics Treatment in Children With Autism Spectrum Disorders in China

Niu, M., Li, Q., Zhang, J., Wen, F., Dang, W., Duan, G., Li, H., Ruan, W., Yang, P., Guan, C., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01084 · Cited by 93 · see citing works

Gut Microbiota: A Modulator of Brain Plasticity and Cognitive Function in Ageing

Leung, K., & Thuret, S. (2015) · Healthcare · doi:10.3390/healthcare3040898 · Cited by 92 · see citing works

Analysis of the Duodenal Microbiome in Autistic Individuals: Association With Carbohydrate Digestion

Kushak, R. I., Winter, H. S., Buie, T. M., Cox, S. B., Phillips, C. D., & Ward, N. L. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001458 · Cited by 92 · see citing works

Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders

Xiong, X., Liu, D., Wang, Y., Zeng, T., & Peng, Y. (2016) · BioMed Research International · doi:10.1155/2016/9485412 · Cited by 90 · see citing works

Improvements in Gastrointestinal Symptoms among Children with Autism Spectrum Disorder Receiving the Delpro� Probiotic and Immunomodulator Formulation

Sichel, J. P. (2013) · Journal of Probiotics & Health · doi:10.4172/2329-8901.1000102 · Cited by 89 · see citing works

Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders

Israelyan, N., & Margolis, K. G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.023 · Cited by 87 · see citing works

Probiotic treatment reduces the autistic-like excitation/inhibition imbalance in juvenile hamsters induced by orally administered propionic acid and clindamycin

El-Ansary, A. K., Bacha, A. G. B., Bjørklund, G., Al-Orf, N., Bhat, R. S., Moubayed, N., & Aabed, K. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0212-8 · Cited by 79 · see citing works

Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome

Liu, G., Yu, Q., Tan, B., Ke, X., Zhang, C., Li, H., Zhang, T.-M., & Lu, Y.-M. (2022) · Gut microbes · doi:10.1080/19490976.2022.2104089 · Cited by 79 · see citing works

Biological effect of aqueous C60 aggregates on Scenedesmus obliquus revealed by transcriptomics and non-targeted metabolomics

Du, C., Zhang, B., He, Y., Hu, C., Ng, Q. X., Zhang, H., Ong, C. N., & ZhifenLin (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2016.10.052 · Cited by 78 · see citing works

Daily intake of Lactobacillus alleviates autistic-like behaviors by ameliorating the 5-hydroxytryptamine metabolic disorder in VPA-treated rats during weaning and sexual maturation

Kong, Q., Wang, B., Tian, P., Li, X., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2021) · Food & Function · doi:10.1039/d0fo02375b · Cited by 78 · see citing works

Beta Peak Frequencies at Rest Correlate with Endogenous GABA+/Cr Concentrations in Sensorimotor Cortex Areas

Baumgarten, T. J., Oeltzschner, G., Hoogenboom, N., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156829 · Cited by 75 · see citing works

A Randomized Controlled Trial into the Effects of Probiotics on Electroencephalography in Preschoolers with Autism

Billeci, L., Callara, A. L., Guiducci, L., Prosperi, M., Morales, M. A., Calderoni, S., Muratori, F., & Santocchi, E. (2023) · Autism · doi:10.1177/13623613221082710 · Cited by 69 · see citing works

Brain‐derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study

Croen, L., Goines, P. E., Braunschweig, D., Yolken, R. H., Yoshida, C. K., Grether, J. K., FIREMAN, B. H., Kharrazi, M., Hansen, R. L., & de Water, J. V. (2008) · Autism Research · doi:10.1002/aur.14 · Cited by 66 · see citing works

Nervous System Injury in Response to Contact With Environmental, Engineered and Planetary Micro- and Nano-Sized Particles

Borisova, Т. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00728 · Cited by 64 · see citing works

Functional analysis of gut microbiota and immunoinflammation in children with autism spectrum disorders

Carissimi, C., Laudadio, I., Palone, F., Fulci, V., Cesi, V., Cardona, F., Alfonsi, C., Cucchiara, S., Isoldi, S., & Stronati, L. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.06.006 · Cited by 62 · see citing works

Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism

Abuaish, S., Al-Otaibi, N. M., Abujamel, T. S., Alzahrani, S. A., Alotaibi, S. M., Alshawakir, Y. A., Aabed, K., & El-Ansary, A. K. (2021) · Brain Sciences · doi:10.3390/brainsci11081038 · Cited by 59 · see citing works

Autism, Gut-Blood-Brain Barrier, and Mast Cells

Theoharides, T. C., & Doyle, R. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181845f48 · Cited by 54 · see citing works

Bifidobacterium longum CCFM1077 Ameliorated Neurotransmitter Disorder and Neuroinflammation Closely Linked to Regulation in the Kynurenine Pathway of Autistic-like Rats

Kong, Q., Chen, Q., Mao, X., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14081615 · Cited by 53 · see citing works

Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience

Mensi, M. M., Rogantini, C., Marchesi, M., Borgatti, R., & Chiappedi, M. A. (2021) · Nutrients · doi:10.3390/nu13062036 · Cited by 51 · see citing works

Probiotics and Prebiotics Alleviate Behavioral Deficits, Inflammatory Response and Gut Dysbiosis in Prenatal VPA-Induced Rodent Model of Autism

Adıgüzel, E., Çiçek, B., Ünal, G., Aydın, M. F., & Keti, D. B. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113961 · Cited by 51 · see citing works

EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study

Nicotera, A. G., Hagerman, R. J., Catania, M. V., Buono, S., Nuovo, S. D., Liprino, E. M., Stracuzzi, E., Giusto, S., Vita, G. D., & Musumeci, S. A. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-03908-2 · Cited by 49 · see citing works

Neurotensin Activates GABAergic Interneurons in the Prefrontal Cortex

Petrie, K. A., Schmidt, D. E., Bubser, M., Fadel, J. R., Carraway, R. E., & Deutch, A. Y. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3579-04.2005 · Cited by 48 · see citing works

Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain

Basta‐Kaim, A., Fijał, K., Ślusarczyk, J., Trojan, E., Głombik, K., Budziszewska, B., Leśkiewicz, M., Regulska, M., Kubera, M., Lasoń, W., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.013 · Cited by 48 · see citing works

Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism

Eissa, N., Jayaprakash, P., Stark, H., Łażewska, D., Kieć‐Kononowicz, K., & Sadek, B. S. (2020) · Biomolecules · doi:10.3390/biom10091251 · Cited by 36 · see citing works

Novel probiotic treatment of autism spectrum disorder associated social behavioral symptoms in two rodent models

Mintál, K., Tóth, A., Hormay, E., Kovács, A., László, K., Bufa, A., Marosvölgyi, T., Kocsis, B., Varga, A., Vizvári, Z., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-09350-2 · Cited by 36 · see citing works

Lactobacillus plantarum ST-III modulates abnormal behavior and gut microbiota in a mouse model of autism spectrum disorder

Guo, M., Li, R., Wang, Y., Ma, S., Zhang, Y., Li, S., Zhang, H., Liu, Z., You, C., & Zheng, H. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113965 · Cited by 36 · see citing works

Employing multi-omics to elucidate the hormetic response against oxidative stress exerted by nC60 on Daphnia pulex

Wang, P., Ng, Q. X., Zhang, B., Wei, Z., Hassan, M. T. U., He, Y., & Ong, C. N. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.04.097 · Cited by 33 · see citing works

Selective Probiotic Treatment Positively Modulates the Microbiota–Gut–Brain Axis in the BTBR Mouse Model of Autism

Pochakom, A., Mu, C., Rho, J. M., Tompkins, T. A., Mayengbam, S., & Shearer, J. (2022) · Brain Sciences · doi:10.3390/brainsci12060781 · Cited by 29 · see citing works

Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice

Lawson, S. K., Gray, A. C., & Woehrle, N. S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.027 · Cited by 25 · see citing works

Molecular Characterization of Probiotics and Their Influence on Children with Autism Spectrum Disorder

Meguid, N. A., Mawgoud, Y. I. A., Bjørklund, G., Mehanne, N. S., Anwar, M., Effat, B. A. E.-K., Chirumbolo, S., & Elrahman, M. M. A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02963-8 · Cited by 24 · see citing works

Reduction in Obsessive Compulsive Disorder and Self-Injurious Behavior With Saccharomyces boulardii in a Child with Autism: A Case Report.

Kobliner, V., Mumper, E. A., & Baker, S. M. (2018) · Europe PMC (PubMed Central) · Cited by 22 · see citing works

Bee Pollen and Probiotics May Alter Brain Neuropeptide Levels in a Rodent Model of Autism Spectrum Disorders

Alghamdi, M. A., AL-Ayadhi, L. Y., Hassan, W. M., Bhat, R. S., Alonazi, M. A., & El-Ansary, A. K. (2022) · Metabolites · doi:10.3390/metabo12060562 · Cited by 20 · see citing works

Supplementation of Lactobacillus Probiotic Strains Supports Gut- Brain-Axis and Defends Autistic Deficits Occurred by Valproic Acid-Induced Prenatal Model of Autism

Katta, S., Mohan, G. K., & Bakshi, V. (2020) · Pharmacognosy Journal · doi:10.5530/pj.2020.12.226 · Cited by 14 · see citing works

Dietary Strategies in Autism Spectrum Disorder (ASD)

Tas, A. A. (2018) · Progress in nutrition · doi:10.23751/pn.v20i4.6693 · Cited by 10 · see citing works

Preliminary Study of Probiotics and Kynurenine Pathway in Autism Spectrum Disorder

Tharawadeephimuk, W., Chaiyasut, C., Sirilun, S., & Sittiprapaporn, P. (2019) · International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology (ECTI-CON) · doi:10.1109/ecti-con47248.2019.8955380 · Cited by 9 · see citing works

Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review

Li, Z., Liao, Y., Zhou, Q. S., Qu, Q., Sheng, M., Lv, L., Yang, J., Shi, Y., & Shi, X. (2022) · Advances in Neurodevelopmental Disorders · doi:10.1007/s41252-022-00266-6 · Cited by 6 · see citing works

The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders

Młynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kopeć, K., Wasiak, J., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17071135 · Cited by 44 · see citing works

Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment

Poupard, L., Page, G., Thoreau, V., & Kaouah, Z. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.24.1179 · Cited by 6 · see citing works

[Experimental grounds for administration of probiotic drugs in conditions of hydroweightlessness].

Ai, K., Vk, I., Volozhin, A. I., et al. (2007) · PubMed · Cited by 2 · see citing works

Gut hormones in microbiota-gut-brain cross-talk

Sun, L.-J., Li, J.-N., & Nie, Y.-Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000706 · Cited by 145 · see citing works

Quercetin improves gut dysbiosis in antibiotic-treated mice

Shi, T., Bian, X., Yao, Z., Wang, Y., Gao, W., & Guo, C. (2020) · Food & Function · doi:10.1039/d0fo01439g · Cited by 130 · see citing works

Gut microbiota dysbiosis in rats with LPS-induced liver diseases affected by Aronia melanocarpa polyphenols

Kong, Y., Li, D., & Meng, X. (2023) · Food Science and Technology · doi:10.5327/fst.130622 · Cited by 1 · see citing works

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

Cui, X., Ye, L., Li, J., Jin, L., Wang, W., Li, S., Bao, M., Wu, S., Li, L., Geng, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18756-2 · Cited by 373 · see citing works