Keasling, Jay D.

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature

Plant biochemistry and biosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 2,805

High-level semi-synthetic production of the potent antimalarial artemisinin

Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature

Plant biochemistry and biosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 2,060

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

Paddon, C. J., & Keasling, J. D. (2014) · Nature Reviews Microbiology

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 675

Biosynthesis of Plant Isoprenoids: Perspectives for Microbial Engineering

Kirby, J., & Keasling, J. D. (2009) · Annual Review of Plant Biology

Plant biochemistry and biosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 478

Biofuels for a sustainable future

Liu, Y., Cruz-Morales, P., Zargar, A., Belcher, M. S., Pang, B., Englund, E., Dan, Q., Yin, K., & Keasling, J. D. (2021) · Cell

Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversion

Cited by 399

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

Chang, M. C. Y., Eachus, R. A., Trieu, W., Ro, D.-K., & Keasling, J. D. (2007) · Nature Chemical Biology

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 364

De novo DNA synthesis using polymerase-nucleotide conjugates.

Palluk, S., Arlow, D. H., de Rond, T., Barthel, S., Kang, J. S., Bector, R., Baghdassarian, H. M., Truong, A. N., Kim, P. W., Singh, A. K., et al. (2018) · Nature Biotechnology

DNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques

Cited by 316

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

Anthony, J. R., Anthony, L. C., Nowroozi, F., Kwon, G., Newman, J. D., & Keasling, J. D. (2009) · Metabolic Engineering

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 292

High‐level production of amorpha‐4,11‐diene in a two‐phase partitioning bioreactor of metabolically engineered Escherichia coli

Newman, J. D., Marshall, J., Chang, M., Nowroozi, F., Paradise, E., Pitera, D., Newman, K. L., & Keasling, J. D. (2006) · Biotechnology and Bioengineering

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 257

Functional Genomic Study of Exogenous n -Butanol Stress in Escherichia coli

Rutherford, B. J., Dahl, R. H., Price, R. E., Szmidt, H. L., Benke, P. I., Mukhopadhyay, A., & Keasling, J. D. (2010) · Applied and Environmental Microbiology

Microbial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

Cited by 227

Highly accurate enzyme turnover number prediction and enzyme engineering with PreKcat

Yu, H., Deng, H., He, J., Keasling, J., & Luo, X. (2023) · Nature Communications

Machine Learning in BioinformaticsEnzyme Catalysis and Immobilization

Cited by 226

UniKP: a unified framework for the prediction of enzyme kinetic parameters

Yu, H., Deng, H., He, J., Keasling, J. D., & Luo, X. (2023) · Nature Communications

Machine Learning in BioinformaticsEnzyme Catalysis and Immobilization

Cited by 226

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

Ro, D.-K., Ouellet, M., Paradise, E. M., Burd, H., Eng, D., Paddon, C. J., Newman, J. D., & Keasling, J. D. (2008) · BMC Biotechnology

Plant biochemistry and biosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 197

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450 BM3

Dietrich, J. A., Yoshikuni, Y., Fisher, K. J., Woolard, F. X., Ockey, D., McPhee, D. J., Renninger, N. S., Chang, M. C. Y., Baker, D., & Keasling, J. D. (2009) · ACS Chemical Biology

Enzyme Catalysis and ImmobilizationMicrobial Metabolic Engineering and Bioproduction

Cited by 186

Isoprenoid drugs, biofuels, and Chemicals–Artemisinin, farnesene, and beyond

George, K. W., Alonso-Gutierrez, J., Keasling, J. D., & Lee, T. S. (2015) · Advances in biochemical engineering, biotechnology

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 185

Importance of systems biology in engineering microbes for biofuel production

Mukhopadhyay, A., Redding, A. M., Rutherford, B. J., & Keasling, J. D. (2008) · Current Opinion in Biotechnology

Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversion

Cited by 129

Engineering triterpene production in Saccharomyces cerevisiae–β‐amyrin synthase from Artemisia annua

Kirby, J., Romanini, D. W., Paradise, E. M., & Keasling, J. D. (2008) · The FEBS Journal

Plant biochemistry and biosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 126

Membrane proteomics of phagosomes suggests a connection to autophagy

Shui, W., Sheu, L., Liu, J., Smart, B., Petzold, C. J., Hsieh, T.-Y., Pitcher, A., Keasling, J. D., & Bertozzi, C. R. (2008) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyPhagocytosis and Immune Regulation

Cited by 114

Alleviation of reactive oxygen species enhances PUFA accumulation in Schizochytrium sp. through regulating genes involved in lipid metabolism

Zhang, S., He, Y., Sen, B., Chen, X., Xie, Y., Keasling, J. D., & Wang, G. (2018) · Metabolic Engineering Communications

Algal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

Cited by 90

Renewable production of high density jet fuel precursor sesquiterpenes from Escherichia coli

Liu, C.-L., Tian, T., Alonso-Gutierrez, J., Garabedian, B., Wang, S., Baidoo, E. E. K., Benites, V., Chen, Y., Petzold, C. J., Adams, P. D., et al. (2018) · Biotechnology for Biofuels

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 70

Nitrogen Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing

Schmidt, M., Pearson, A. N., Incha, M. R., Thompson, M. G., Baidoo, E. E. K., Kakumanu, R., Mukhopadhyay, A., Shih, P. M., Deutschbauer, A. M., Blank, L. M., et al. (2022) · Applied and Environmental Microbiology

Microbial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

Cited by 28

Biosensor Guided Polyketide Synthases Engineering for Optimization of Domain Exchange Boundaries

Englund, E., Schmidt, M., Nava, A. A., Klass, S., Keiser, L., Dan, Q., Katz, L., Yuzawa, S., & Keasling, J. D. (2023) · Nature Communications

Microbial Natural Products and BiosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 22

Biosensor Guided Polyketide Synthase Engineering for Optimization of Domain Exchange Boundaries

Englund, E., Schmidt, M., Nava, A., Dan, Q., Katz, L., Yuzawa, S., & Keasling, J. (2022) · Nature Communications

Microbial Natural Products and BiosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 22

Manipulation of intracellular magnesium levels in Saccharomyces cerevisiae with deletion of magnesium transporters

da Costa, B. M. T., Cornish, K., & Keasling, J. D. (2007) · Applied Microbiology and Biotechnology

Fungal and yeast genetics researchMagnesium in Health and Disease

Cited by 14