Makriyannis, Alexandros

Identification and Functional Characterization of Brainstem Cannabinoid CB2Receptors

Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., et al. (2005) · Science

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 1,470

Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

Beltramo, M., Stella, N., Calignano, A., Lin, S. Y., Makriyannis, A., & Piomelli, D. (1997) · Science

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 813

CB 2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

Ibrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., et al. (2005) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 521

Activation of CB 2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 491

Synthon-based ligand discovery in virtual libraries of over 11 billion compounds

Sadybekov, A. A., Sadybekov, A. V., Liu, Y., Iliopoulos-Tsoutsouvas, C., Huang, X.-P., Pickett, J., Houser, B., Patel, N., Tran, N. K., Tong, F., et al. (2022) · Nature

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 417

CB2 cannabinoid receptor-mediated peripheral antinociception

Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 391

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

Gunduz-Cinar, O., MacPherson, K. P., Cinar, R., Gamble-George, J., Sugden, K., Williams, B., Godlewski, G., Ramikie, T. S., Gorka, A. X., Alapafuja, S. O., et al. (2013) · Molecular Psychiatry

Cannabis and Cannabinoid ResearchMemory and Neural Mechanisms

Cited by 307

123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors

Gatley, S. J., Gifford, A. N., Volkow, N. D., Lan, R., & Makriyannis, A. (1996) · European Journal of Pharmacology

Cannabis and Cannabinoid ResearchRadiopharmaceutical Chemistry and Applications

Cited by 252

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172

Fegley, D., Kathuria, S., Mercier, R., Li, C., Goutopoulos, A., Makriyannis, A., & Piomelli, D. (2004) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 230

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 183

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

Rahn, E. J., Makriyannis, A., & Hohmann, A. G. (2007) · British Journal of Pharmacology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 146

Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats

Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 116

Large Receptor Reserve for Cannabinoid Actions in the Central Nervous System

Gifford, A. N., Bruneus, M., Gatley, S. J., Lan, R., Makriyannis, A., & Volkow, N. D. (1999) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 100

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects

Godlewski, G., Alapafuja, S. O., Bátkai, S., Nikas, S. P., Cinar, R., Offertáler, L., Osei-Hyiaman, D., Liu, J., Mukhopadhyay, B., Harvey-White, J., et al. (2010) · Chemistry & Biology

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 95

The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Deng, L., Guindon, J., Vemuri, V. K., Thakur, G. A., White, F. A., Makriyannis, A., & Hohmann, A. G. (2012) · Molecular Pain

Pain Mechanisms and TreatmentsCancer Treatment and Pharmacology

Cited by 94

The CB1Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability

Gueye, A. B., Pryslawsky, Y., Trigo, J. M., Poulia, N., Delis, F., Antoniou, K., Loureiro, M., Laviolette, S. R., Vemuri, K., Makriyannis, A., et al. (2016) · International Journal of Neuropsychopharmacology

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 74

Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys.

Schindler, C. W., Redhi, G. H., Vemuri, K., Makriyannis, A., Le Foll, B., Bergman, J., Goldberg, S. R., & Justinova, Z. (2016) · Neuropsychopharmacology

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 73

Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters

Wood, J. T., Williams, J. S., Pandarinathan, L., Courville, A., Keplinger, M. R., Janero, D. R., Vouros, P., Makriyannis, A., & Lammi-Keefe, C. J. (2008) · Clinical Chemistry and Laboratory Medicine

Cannabis and Cannabinoid ResearchClinical Laboratory Practices and Quality Control

Cited by 71

CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats

Wills, K. L., Vemuri, K., Kalmar, A., Lee, A., Limebeer, C. L., Makriyannis, A., & Parker, L. A. (2014) · Psychopharmacology

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 29