Activation of CB 2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922 · see citing works

Quantitative assessment of tactile allodynia in the rat paw

Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740 · see citing works

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works

Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms

Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 3,362 · see citing works

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069 · see citing works

Classification of chronic pain

Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952 · see citing works

Efficient Analysis of Experimental Observations

Dixon, W. J. (1980) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.20.040180.002301 · Cited by 2,216 · see citing works

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159 · see citing works

Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations

Galiègue, S., Mary, S., Marchand, J., Dussossoy, D., Carrière, D., Carayon, P., Bouaboula, M., Shire, D. J., Fur, G. L., & Casellas, P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20780.x · Cited by 1,751 · see citing works

Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action

Sindrup, S. H., & Jensen, T. S. (1999) · Pain · doi:10.1016/s0304-3959(99)00154-2 · Cited by 1,142 · see citing works

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,065 · see citing works

A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes

Kingery, W. S. (1997) · Pain · doi:10.1016/s0304-3959(97)00049-3 · Cited by 678 · see citing works

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

Facci, L., Dal Toso, R., Romanello, S., Buriani, A., Skaper, S. D., & Leon, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3376 · Cited by 632 · see citing works

Inflammatory mediators of pain

Dray, A. (1995) · British Journal of Anaesthesia · doi:10.1093/bja/75.2.125 · Cited by 601 · see citing works

HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor

Hanus, L. O., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R., & Fride, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14228 · Cited by 574 · see citing works

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

Buckley, N. E., McCoy, K. L., Mezey, É., Bonner, T. I., Zimmer, A. M., Felder, C. C., Glass, M., & Zimmer, A. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00211-9 · Cited by 544 · see citing works

Structure−Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists

Lan, R., Liu, Q., Fan, P., Lin, S., Fernando, S. R., McCallion, D. S. E., Pertwee, R. G., & Makriyannis, A. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980363y · Cited by 447 · see citing works

Post Stroke Pain: Identification, Assessment, and Therapy

Harrison, R. A., & Field, T. S. (2015) · Cerebrovascular Diseases · doi:10.1159/000375397 · Cited by 418 · see citing works

Agonist‐inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630

Ross, R. A., Brockie, H. C., Stevenson, L., Murphy, V. L., Templeton, F., Makriyannis, A., & Pertwee, R. G. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702351 · Cited by 407 · see citing works

CB2 cannabinoid receptor-mediated peripheral antinociception

Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works

Cannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune System

Schatz, A. R., Lee, M., Condie, R. B., Pulaski, J. T., & Kaminski, N. E. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8034 · Cited by 359 · see citing works

The clinical picture of neuropathic pain

Jensen, T. S., Gottrup, H., Sindrup, S. H., & Bach, F. W. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01302-4 · Cited by 355 · see citing works

Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study

Hohmann, A. G., & Herkenham, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00524-7 · Cited by 301 · see citing works

123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors

Gatley, S. J., Gifford, A. N., Volkow, N. D., Lan, R., & Makriyannis, A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00279-8 · Cited by 252 · see citing works

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors

Quartilho, A., Mata, H. P., Ibrahim, M. M., Vanderah, T. W., Porreca, F., Makriyannis, A., & Malan, T. P. (2003) · Anesthesiology · doi:10.1097/00000542-200310000-00031 · Cited by 243 · see citing works

Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats

Ossipov, M. H., Bian, D., Malan, P. T., Lai, J. Y., & Porreca, F. (1999) · Pain · doi:10.1016/s0304-3959(98)00187-0 · Cited by 218 · see citing works

Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers

Hájos, N., & Freund, T. F. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00157-0 · Cited by 198 · see citing works

Neurogenic pain syndromes and their management

Bowsher, D. R. (1991) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072498 · Cited by 182 · see citing works

Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system

Griffin, G., Wray, E. J., Tao, Q., McAllister, S. D., Rorrer, W. K., Aung, M. M., Martin, B. R., & Abood, M. E. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00402-1 · Cited by 148 · see citing works

Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors

Gatley, S. J., Lan, R., Pyatt, B. E., Gifford, A. N., Volkow, N. D., & Makriyannis, A. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00690-5 · Cited by 140 · see citing works

Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain

Ma, W., & Eisenach, J. C. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01940.x · Cited by 136 · see citing works

Neurogenic inf ammation in an animal model of neuropathic pain

Daemen, M. A. R. C., Kurvers, H., Kitslaar, P. J. E. H. M., Slaaf, D. W., Bullens, P. H. J., & van den Wildenberg, F. A. J. M. (1998) · Neurological Research · doi:10.1080/01616412.1998.11740483 · Cited by 91 · see citing works

AM630 antagonism of cannabinoid-stimulated [35S]GTPγS binding in the mouse brain

Hosohata, Y., Quock, R. M., Hosohata, K., Makriyannis, A., Consroe, P. F., Roeske, W. R., & Yamamura, H. I. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00047-2 · Cited by 67 · see citing works

Neurogenic inflammation and reflex sympathetic dystrophy (in vivo and in vitro assessment in an experimental model).

Daemen, M. J. A. P., Kurvers, H. A. J. M., Bullens, P. H. J., et al. (1998) · PubMed · Cited by 23 · see citing works

Chronic pain

Rowbotham, M. C. (1995) · Neurology · doi:10.1212/wnl.45.12_suppl_9.s5 · Cited by 22 · see citing works

Dopamine D2 receptors play a role in the (−)-apomorphine-like discriminative stimulus effects of (+)-PD 128907

Kleven, M. S., & Koek, W. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00002-2 · Cited by 15 · see citing works

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works

The molecular logic of endocannabinoid signalling

Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works

The endocannabinoid system and its therapeutic exploitation

Marzo, V. D., Bifulco, M., & Petrocellis, L. D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1495 · Cited by 1,090 · see citing works

Distribution of cannabinoid receptors in the central and peripheral nervous system

Mackie, K. (2005) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-26573-2_10 · Cited by 744 · see citing works

Cannabinoid-based drugs as anti-inflammatory therapeutics

Klein, T. W. (2005) · Nature Reviews Immunology · doi:10.1038/nri1602 · Cited by 728 · see citing works

CB ₂ cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

Ibrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409888102 · Cited by 521 · see citing works

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

Yiangou, Y., Facer, P., Durrenberger, P., Chessell, I. P., Naylor, A., Bountra, C., Banati, R. R., & Anand, P. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-12 · Cited by 509 · see citing works

Cannabinoid CB ₂ receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works

Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α

LoVerme, J., Russo, R., La Rana, G., Fu, J., Farthing, J., Mattace-Raso, G., Meli, R., Hohmann, A., Calignano, A., & Piomelli, D. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111385 · Cited by 316 · see citing works

Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works

The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases

Lowe, H., Toyang, N., Steele, B., Bryant, J., & Ngwa, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179472 · Cited by 303 · see citing works

The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works

CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms

Beltramo, M., Bernardini, N., Bertorelli, R., Campanella, M., Nicolussi, E., Fredduzzi, S., & Reggiani, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04684.x · Cited by 290 · see citing works

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes

Manzanares, J., Julian, M., & Carrascosa, A. (2006) · Current Neuropharmacology · doi:10.2174/157015906778019527 · Cited by 287 · see citing works

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy

Valenzano, K. J., Tafesse, L., Lee, G., Harrison, J. E., Boulet, J. M., Gottshall, S. L., Mark, L., Pearson, M. S., Miller, W., Shan, S., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.12.008 · Cited by 288 · see citing works

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

Jayamanne, A., Greenwood, R., Mitchell, V. A., Aslan, S., Piomelli, D., & Vaughan, C. W. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706510 · Cited by 287 · see citing works

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

Staton, P. C., Hatcher, J. P., Walker, D. J., Morrison, A. D., Shapland, E. M., Hughes, J. P., Chong, E., Mander, P. K., Green, P. J., Billinton, A., et al. (2008) · Pain · doi:10.1016/j.pain.2008.04.006 · Cited by 270 · see citing works

Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects

Onaivi, E. S., Ishiguro, H., Gong, J.-P., Patel, S., Meozzi, P. A., Myers, L., Perchuk, A., Mora, Z., Tagliaferro, P. A., Gardner, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001640 · Cited by 257 · see citing works

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons

Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., & Winter, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.009 · Cited by 251 · see citing works

The endogenous cannabinoid system and its role in nociceptive behavior

Cravatt, B. F., & Lichtman, A. H. (2004) · Journal of Neurobiology · doi:10.1002/neu.20080 · Cited by 203 · see citing works

Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2005.10.003 · Cited by 199 · see citing works

Crucial Role of CB₂Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

Racz, I., Nadal, X., Alferink, J., Baños, J. E., Rehnelt, J., Martín, M., Pintado, B., Gutierrez-Adan, A., Sanguino, E., Manzanares, J., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3400-08.2008 · Cited by 195 · see citing works

Exercise-induced endocannabinoid signaling is modulated by intensity

Raichlen, D. A., Foster, A. D., Seillier, A., Giuffrida, A., & Gerdeman, G. L. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2495-5 · Cited by 181 · see citing works

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3′-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

Russo, R., LoVerme, J., La Rana, G., Compton, T. R., Parrott, J., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Calignano, A., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.119941 · Cited by 182 · see citing works

Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

Klein, T. W., & Cabral, G. A. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-005-9007-x · Cited by 172 · see citing works

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

Anand, U., Otto, W. R., Sanchez-Herrera, D., Facer, P., Yiangou, Y., Korchev, Y., Birch, R., Benham, C., Bountra, C., Chessell, I. P., et al. (2008) · Pain · doi:10.1016/j.pain.2008.06.007 · Cited by 166 · see citing works

Cannabinoid CB₂ receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain

Elmes, S. J. R., Jhaveri, M. D., Smart, D., Kendall, D. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03690.x · Cited by 160 · see citing works

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Chang, L., Luo, L., Palmer, J. A., Sutton, S., Wilson, S. J., Barbier, A. J., Breitenbucher, J. G., Chaplan, S. R., & Webb, M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706699 · Cited by 155 · see citing works

Activation of cannabinoid CB₁ and CB₂ receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

Rahn, E. J., Makriyannis, A., & Hohmann, A. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707333 · Cited by 146 · see citing works

Central and peripheral sites of action for CB ₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

Hsieh, G. C., Pai, M., Chandran, P., Hooker, B. A., Zhu, C. Z., Salyers, A. K., Wensink, E. J., Zhan, C., Carroll, W. A., Dart, M. J., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01046.x · Cited by 139 · see citing works

<i>In vitro</i>and<i>in vivo</i>characterization of A‐796260: a selective cannabinoid CB₂receptor agonist exhibiting analgesic activity in rodent pain models

Yao, B. B., Hsieh, G. C., Frost, J. M., Fan, Y., Garrison, T. R., Daza, A. V., Grayson, G. K., Zhu, C. Z., Pai, M., Chandran, P., et al. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707568 · Cited by 140 · see citing works

Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain

Walczak, J.-S., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.010 · Cited by 133 · see citing works

Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats

Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116 · see citing works

Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat

LaBuda, C. J., & Little, P. J. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.11.008 · Cited by 108 · see citing works

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

Grenald, S. A., Young, M. A., Wang, Y., Ossipov, M. H., Ibrahim, M. M., Largent-Milnes, T. M., & Vanderah, T. W. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.008 · Cited by 97 · see citing works

The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB₂ Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Deng, L., Guindon, J., Vemuri, V. K., Thakur, G. A., White, F. A., Makriyannis, A., & Hohmann, A. G. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-71 · Cited by 94 · see citing works

Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain

Guindon, J., & Beaulieu, P. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.002 · Cited by 90 · see citing works

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain

Yamamoto, W., Mikami, T., & Iwamura, H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.010 · Cited by 89 · see citing works

Evidence for a novel functional role of cannabinoid CB₂ receptors in the thalamus of neuropathic rats

Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06162.x · Cited by 88 · see citing works

Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain

Costa, B., Colleoni, M., Conti, S., Trovato, A. E., Bianchi, M., Sotgiu, M. L., & Giagnoni, G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705587 · Cited by 89 · see citing works

Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat

Dyson, A., Peacock, M., Chen, A., Courade, J.-P., Yaqoob, M., Groarke, A., Brain, C., Loong, Y., & Fox, A. (2005) · Pain · doi:10.1016/j.pain.2005.03.037 · Cited by 85 · see citing works

MDA7: a novel selective agonist for CB₂ receptors that prevents allodynia in rat neuropathic pain models

Naguib, M., Diaz, P., Xu, J. J., Astruc‐Diaz, F., Craig, S., Vivas‐Mejia, P., & Brown, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.340 · Cited by 82 · see citing works

Involvement of the opioid and cannabinoid systems in pain control: New insights from knockout studies

Nadal, X., La Porta, C., Andreea Bura, S., & Maldonado, R. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.077 · Cited by 76 · see citing works

The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy

Wallace, V. C. J., Segerdahl, A. R., Lambert, D. M., Vandevoorde, S., Blackbeard, J., Pheby, T., Hasnie, F., & Rice, A. S. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707326 · Cited by 66 · see citing works

Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(−/−) and not CB2(−/−) mice in models of acute and persistent pain

Sain, N. M. H., Liang, A., Kane, S. A., & Urban, M. O. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.004 · Cited by 51 · see citing works

Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats

Kawasaki, Y., Kohno, T., & Ji, R.-R. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093583 · Cited by 44 · see citing works

Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models

Mitchell, V. A., Greenwood, R., Jayamanne, A., & Vaughan, C. W. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04692.x · Cited by 43 · see citing works

AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors

La Rana, G., Russo, R., D'Agostino, G., Sasso, O., Raso, G. M., Iacono, A., Meli, R., Piomelli, D., & Calignano, A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.10.021 · Cited by 42 · see citing works

Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury

Hama, A., & Sagen, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.09.002 · Cited by 40 · see citing works

Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain

Leichsenring, A., Andriske, M., Bäcker, I., Stichel, C. C., & Lübbert, H. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-008-0386-4 · Cited by 39 · see citing works

Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain

Liu, C., & Walker, J. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00498.2006 · Cited by 37 · see citing works

A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors

McGaraughty, S., Chu, K. L., Dart, M. J., Yao, B. B., & Meyer, M. D. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.015 · Cited by 31 · see citing works

Effect of Cannabinoid Receptor Agonists on Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathy

Bujalska, M. (2008) · Pharmacology · doi:10.1159/000156485 · Cited by 20 · see citing works

Cannabinoid receptor systems: therapeutic targets for tumour intervention.

Jones, S., & Howl, J. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.6.749 · Cited by 13 · see citing works

Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors

Mukherjee, S., Adams, M., Whiteaker, K. L., Daza, A. V., Kage, K., Cassar, S. C., Meyer, M., & Yao, B. B. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.09.058 · Cited by 99 · see citing works

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

Buckley, N. E., McCoy, K. L., Mezey, É., Bonner, T. I., Zimmer, A. M., Felder, C. C., Glass, M., & Zimmer, A. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00211-9 · Cited by 544 · see citing works

Identification and biochemical analyses of selective CB2 agonists

Scott, C. E., Tang, Y., Alt, A. J., Burford, N. T., Gerritz, S. W., Ogawa, L. M., Zhang, L., & Kendall, D. A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.03.054 · Cited by 9 · see citing works

Cannabinoid CB1 and CB2 Receptor Ligand Specificity and the Development of CB2-Selective Agonists

Ashton, J. C., Wright, J., McPartland, J. M., & Tyndall, J. D. A. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784567716 · Cited by 91 · see citing works

Targeting cannabinoid agonists for inflammatory and neuropathic pain

Cheng, Y., & Hitchcock, S. A. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.7.951 · Cited by 103 · see citing works