Spector, Tim D.

Genetic epidemiology of hip and knee osteoarthritis

Valdes, A. M., & Spector, T. D. (2011) · Nature Reviews Rheumatology

Osteoarthritis Treatment and MechanismsGenetic Associations and Epidemiology

Cited by 256

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimäki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., et al. (2012) · PLoS Genetics

Genetic Associations and EpidemiologyHormonal and reproductive studies

Cited by 250

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O’Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., et al. (2016) · Proceedings of the National Academy of Sciences

Fibroblast Growth Factor ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 241

Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women

Richards, J. B., Valdes, A. M., Gardner, J. P., Paximadas, D., Kimura, M., Nessa, A., Lu, X., Surdulescu, G. L., Swaminathan, R., Spector, T. D., et al. (2007) · The American Journal of Clinical Nutrition

Vitamin D Research StudiesTelomeres, Telomerase, and Senescence

Cited by 237

Genetic influence on early age-related maculopathy

Hammond, C. J., Webster, A. R., Snieder, H., Bird, A. C., Gilbert, C. E., & Spector, T. D. (2002) · Ophthalmology

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 237

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

Menni, C., Zierer, J., Pallister, T., Jackson, M. A., Long, T., Mohney, R. P., Steves, C. J., Spector, T. D., & Valdes, A. M. (2017) · Scientific Reports

Gut microbiota and healthFatty Acid Research and Health

Cited by 237

The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations

Keskitalo, K., Tuorila, H., Spector, T. D., Cherkas, L. F., Knaapila, A., Kaprio, J., Silventoinen, K., & Perola, M. (2008) · The American Journal of Clinical Nutrition

Eating Disorders and BehaviorsNutrition, Health and Food Behavior

Cited by 223

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A.-P., Thorleifsson, G., Ladenvall, C., Kals, M., et al. (2013) · PLoS Medicine

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 203

A metabolome-wide association study of kidney function and disease in the general population

Sekula, P., Goek, O.-N., Quaye, L., Barrios, C., Levey, A. S., Römisch-Margl, W., Menni, C., Yet, I., Gieger, C., Inker, L. A., et al. (2016) · Journal of the American Society of Nephrology

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

Cited by 203

Gut-Microbiota-Metabolite Axis in Early Renal Function Decline

Barrios, C., Beaumont, M., Pallister, T., Villar, J., Goodrich, J. K., Clark, A., Pascual, J., Ley, R. E., Spector, T. D., Bell, J. T., et al. (2015) · PLOS ONE

Gut microbiota and healthChronic Kidney Disease and Diabetes

Cited by 175

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior

Cornelis, M. C., Kacprowski, T., Menni, C., Gustafsson, S., Pivin, E., Adamski, J., Artati, A., Eap, C. B., Ehret, G., Friedrich, N., et al. (2016) · Human Molecular Genetics

Coffee research and impactsGenetic Associations and Epidemiology

Cited by 175

Human telomere biology: pitfalls of moving from the laboratory to epidemiology

Aviv, A., Valdes, A. M., & Spector, T. D. (2006) · International Journal of Epidemiology

Telomeres, Telomerase, and SenescenceGenetic Associations and Epidemiology

Cited by 172

Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis

Valdes, A. M., Richards, J. B., Gardner, J. P., Swaminathan, R., Kimura, M., Xiaobin, L., Aviv, A., & Spector, T. D. (2007) · Osteoporosis International

Telomeres, Telomerase, and SenescenceBone health and osteoporosis research

Cited by 164

Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

Björk, J. R., Bolte, L. A., Maltez Thomas, A., Lee, K. A., Rossi, N., Wind, T. T., Smit, L. M., Armanini, F., Asnicar, F., Blanco-Miguez, A., et al. (2024) · Nature Medicine

Gut microbiota and healthCancer Immunotherapy and Biomarkers

Cited by 156

Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study

Bowyer, R. C. E., Jackson, M. A., Le Roy, C. I., Ni Lochlainn, M., Spector, T. D., Dowd, J. B., & Steves, C. J. (2019) · Microorganisms

Gut microbiota and healthHealth disparities and outcomes

Cited by 150

Circulating Proteomic Signatures of Chronological Age

Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., et al. (2015) · The Journals of Gerontology: Series A

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 144

Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals

Fackelmann, G., Manghi, P., Carlino, N., Heidrich, V., Piccinno, G., Ricci, L., Piperni, E., Arrè, A., Bakker, E., Creedon, A. C., et al. (2025) · Nature Microbiology

Gut microbiota and healthNutritional Studies and Diet

Cited by 142

Use of dietary indices to control for diet in human gut microbiota studies

Bowyer, R. C. E., Jackson, M. A., Pallister, T., Skinner, J., Spector, T. D., Welch, A. A., & Steves, C. J. (2018) · Microbiome

Gut microbiota and healthNutritional Studies and Diet

Cited by 140

Genetic and Environmental Influences on Total-Body and Central Abdominal Fat: The Effect of Physical Activity in Female Twins

Samaras, K., Kelly, P. J., Chiano, M. N., Spector, T. D., & Campbell, L. V. (1999) · Annals of Internal Medicine

Genetics and Physical PerformanceObesity, Physical Activity, Diet

Cited by 133

Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort

Panicker, V., Wilson, S. G., Spector, T. D., Brown, S. J., Falchi, M., Richards, J. B., Surdulescu, G. L., Lim, E. M., Fletcher, S. J., & Walsh, J. P. (2008) · Clinical Endocrinology

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 128

Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes

Ruth, K. S., Campbell, P. J., Chew, S., Lim, E. M., Hadlow, N., Stuckey, B. G., Brown, S. J., Feenstra, B., Joseph, J., Surdulescu, G. L., et al. (2016) · European Journal of Human Genetics

Genetic Associations and EpidemiologySexual Differentiation and Disorders

Cited by 121

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

Valles-Colomer, M., Menni, C., Berry, S. E., Valdes, A. M., Spector, T. D., & Segata, N. (2023) · Nature Medicine

Gut microbiota and healthNutrition, Genetics, and Disease

Cited by 114

Postprandial glycaemic dips predict appetite and energy intake in healthy individuals

Wyatt, P., Berry, S. E., Finlayson, G., O’Driscoll, R., Hadjigeorgiou, G., Drew, D. A., Khatib, H. A., Nguyen, L. H., Linenberg, I., Chan, A. T., et al. (2021) · Nature Metabolism

Regulation of Appetite and ObesityDietary Effects on Health

Cited by 114

Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma

Bolte, L. A., Lee, K. A., Björk, J. R., Leeming, E. R., Campmans-Kuijpers, M. J. E., de Haan, J. J., Vila, A. V., Maltez-Thomas, A., Segata, N., Board, R., et al. (2023) · JAMA Oncology

Cancer Immunotherapy and BiomarkersNutritional Studies and Diet

Cited by 106