Human telomere biology: pitfalls of moving from the laboratory to epidemiology

Statistical Inference

Casella, G., & Berger, R. L. (1993) · Chapman & Hall/CRC eBooks · doi:10.1201/9781003456285 · Cited by 5,835 · see citing works

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works

Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias

MACMAHON, S. (1990) · The Lancet · doi:10.1016/0140-6736(90)90878-9 · Cited by 4,253 · see citing works

Telomere measurement by quantitative PCR

Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works

Accelerated telomere shortening in response to life stress

Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works

Association between telomere length in blood and mortality in people aged 60 years or older

Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761 · see citing works

Free-Radical Chemistry of Cigarette Smoke and Its Toxicological Implications

CHURCH, D. F., & PRYOR, W. A. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.8564111 · Cited by 1,442 · see citing works

Telomere states and cell fates

Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,372 · see citing works

Obesity, cigarette smoking, and telomere length in women

Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363 · see citing works

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

Pryor, W. A., & Stone, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39148.x · Cited by 1,154 · see citing works

Heterogeneity in telomere length of human chromosomes

Lansdorp, P. M. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.5.685 · Cited by 879 · see citing works

Probability and statistical inference

(2008) · Choice Reviews Online · doi:10.5860/choice.45-6219 · Cited by 872 · see citing works

Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study

Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773 · see citing works

Genetic determination of telomere size in humans: a twin study of three age groups.

Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

Vaziri, H., Schächter, F., Uchida, I. A., Wei, L., Zhu, X., Effros, R. B., Cohen, D., & Harley, C. (1993) · PubMed · Cited by 734 · see citing works

Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia

Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood

Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709 · see citing works

Telomere Length as an Indicator of Biological Aging

Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 621 · see citing works

Telomere shortening in atherosclerosis

Samani, N. J., Boultby, R., Butler, R., Thompson, J. R., & Goodall, A. H. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05633-1 · Cited by 609 · see citing works

White Cell Telomere Length and Risk of Premature Myocardial Infarction

Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H., & Samani, N. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000067426.96344.32 · Cited by 590 · see citing works

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry

Rufer, N., Dragowska, W. H., Thornbury, G., Roosnek, E. E., & Lansdorp, P. M. (1998) · Nature Biotechnology · doi:10.1038/nbt0898-743 · Cited by 547 · see citing works

Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study

Demissie, S., Levy, D., Benjamin, E. J., Cupples, L. A., Gardner, J. P., Herbert, A., Kimura, M., Larson, M. G., Meigs, J. B., Keaney, J. F., et al. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00224.x · Cited by 508 · see citing works

Telomere Length in the Newborn

Okuda, K., Bardeguez, A., Gardner, J. P., Rodriguez, P., Ganesh, V., Kimura, M., Skurnick, J., Awad, G., & Aviv, A. (2002) · Pediatric Research · doi:10.1203/00006450-200209000-00012 · Cited by 507 · see citing works

Age-related changes in human blood lymphocyte subpopulations

Erkeller-Yüksel, F., Deneys, V., Yuksel, B., Hannet, I., Hulstaert, F., Hamilton, C., Mackinnon, H., Turner‐Stokes, L. F., Munhyeshuli, V., Vanlangendonck, F., et al. (1992) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80430-5 · Cited by 424 · see citing works

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11091 · Cited by 418 · see citing works

Telomere shortening in T cells correlates with Alzheimer's disease status

Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 409 · see citing works

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts

Monteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376 · see citing works

Telomere length and possible link to X chromosome

Nawrot, T. S., Staessen, J. A., Gardner, J. P., & Aviv, A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15535-9 · Cited by 370 · see citing works

Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition

Gardner, J. P., Li, S., Srinivasan, S. R., Chen, W., Kimura, M., Lu, X., Berenson, G. S., & Aviv, A. (2005) · Circulation · doi:10.1161/01.cir.0000163550.70487.0b · Cited by 361 · see citing works

Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial

Jeanclos, E. M., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J., & Aviv, A. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.195 · Cited by 352 · see citing works

Correcting for Regression Dilution Bias: Comparison of Methods for a Single Predictor Variable

Frost, C. D., & Thompson, S. G. (2000) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/1467-985x.00164 · Cited by 319 · see citing works

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population‐based study

Martin-Ruiz, C. M., Gussekloo, J., van Heemst, D., von Zglinicki, T., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00171.x · Cited by 314 · see citing works

Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects

Benetos, A., Gardner, J. P., Zureik, M., Labat, C., Xiaobin, L., Adamopoulos, C., Temmar, M., Bean, K. E., Thomas, F., & Aviv, A. (2004) · Hypertension · doi:10.1161/01.hyp.0000113081.42868.f4 · Cited by 313 · see citing works

Ageing of lymphocytes and lymphocytes in the aged

Globerson, A., & Effros, R. B. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01714-x · Cited by 309 · see citing works

The effects of social status on biological aging as measured by white‐blood‐cell telomere length

Cherkas, L. F., Aviv, A., Valdes, A. M., Hunkin, J., Gardner, J. P., Surdulescu, G. L., Kimura, M., & Spector, T. D. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00222.x · Cited by 306 · see citing works

Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

von Zglinicki, T., Serra, V., Lorenz, M., Saretzki, G. C., Lenzen-Großimlinghaus, R., Gessner, R. V., Risch, A., & Steinhagen‐Thiessen, E. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780184 · Cited by 305 · see citing works

Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes

Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02006.x · Cited by 263 · see citing works

Mapping of a Major Locus that Determines Telomere Length in Humans

Vasa-Nicotera, M., Brouilette, S., Mangino, M., Thompson, J. R., Braund, P., Clemitson, J.-R., Mason, A., Bodycote, C. L., Raleigh, S. M., Louis, E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/426734 · Cited by 257 · see citing works

Mapping Genetic Loci That Determine Leukocyte Telomere Length in a Large Sample of Unselected Female Sibling Pairs

Andrew, T., Aviv, A., Falchi, M., Surdulescu, G. L., Gardner, J. P., Lu, X., Kimura, M., Kato, B. S., Valdes, A. M., & Spector, T. D. (2006) · The American Journal of Human Genetics · doi:10.1086/500052 · Cited by 252 · see citing works

Reactive Oxygen Species Are Involved in Smoking-Induced Dysfunction of Nitric Oxide Biosynthesis and Upregulation of Endothelial Nitric Oxide Synthase

Barua, R. S., Ambrose, J. A., Srivastava, S. K., DeVoe, M. C., & Eales‐Reynolds, L. (2003) · Circulation · doi:10.1161/01.cir.0000066691.52789.be · Cited by 246 · see citing works

No Association Between Telomere Length and Survival Among the Elderly and Oldest Old

Bischoff, C., Petersen, H. C., Graakjær, J., Andersen‐Ranberg, K., Vaupel, J. W., Bohr, V. A., Kølvraa, S., & Christensen, K. (2006) · Epidemiology · doi:10.1097/01.ede.0000199436.55248.10 · Cited by 243 · see citing works

Paternal age is positively linked to telomere length of children

Unryn, B. M., Cook, L. S., & Riabowol, K. T. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00144.x · Cited by 224 · see citing works

Telomere analysis by fluorescence in situ hybridization and flow cytometry

Hultdin, M., Gronlund, E., Norrback, K.-F., Eriksson-Lindstrom, E., Roos, G., & Just, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.16.3651 · Cited by 218 · see citing works

Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction

Smith, C. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00570-6 · Cited by 217 · see citing works

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages

Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233561100 · Cited by 216 · see citing works

Age-Related Changes in Human Blood Lymphocyte Subpopulations

Hulstaert, F., Hannet, I., Deneys, V., Munhyeshuli, V., Reichert, T., Bruyère, M. D., & Strauss, K. W. (1994) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1994.1023 · Cited by 211 · see citing works

Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age

Son, N. H., Murray, S., Yanovski, J., Hodes, R. J., & Weng, N.-P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1191 · Cited by 200 · see citing works

In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4 + but not CD8 + T cells depleted?

Ribeiro, R. M., Mohri, H., Ho, D. D., & Perelson, A. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242358099 · Cited by 199 · see citing works

Telomeres and human aging: facts and fibs

Aviv, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.51.pe43 · Cited by 198 · see citing works

Menopause Modifies the Association of Leukocyte Telomere Length with Insulin Resistance and Inflammation

Aviv, A., Valdes, A. M., Gardner, J. P., Swaminathan, R., Kimura, M., & Spector, T. D. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1814 · Cited by 167 · see citing works

Developmental differences in the immortalization of lung fibroblasts by telomerase

Forsyth, N. R., Evans, A., Shay, J. W., & Wright, W. E. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00057.x · Cited by 156 · see citing works

Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype

Nociari, M., Telford, W. G., & Russo, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3327 · Cited by 154 · see citing works

Telomere instability in the male germline

Baird, D. M., Britt‐Compton, B., Rowson, J., Amso, N. N., Gregory, L., & Kipling, D. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi424 · Cited by 152 · see citing works

Cardiovascular disease in rheumatoid arthritis

Kaplan, M. J. (2006) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000218951.65601.bf · Cited by 135 · see citing works

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works

Telomere length measurements in leukocyte subsets by automated multicolor flow‐FISH

Baerlocher, G. M., & Lansdorp, P. M. (2003) · Cytometry Part A · doi:10.1002/cyto.a.10064 · Cited by 112 · see citing works

Interplay between telomere length and telomerase in human leukocyte differentiation and aging

Weng, N. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.861 · Cited by 107 · see citing works

Genetic Manipulation of Telomerase in HIV-Specific CD8+ T Cells: Enhanced Antiviral Functions Accompany the Increased Proliferative Potential and Telomere Length Stabilization

Dagarag, M. D., Evazyan, T., Rao, N. P., & Effros, R. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6303 · Cited by 107 · see citing works

Telomere maintenance in human B lymphocytes

Martens, U. M., Brass, V., Sedlacek, L., Pantić, M., Exner, C., Guo, Y., Engelhardt, M. M., Lansdorp, P. M., Waller, C. F., & Lange, W. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03910.x · Cited by 94 · see citing works

Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system

van Baarle, D., Tsegaye, A., Miedema, F. F., & Akbar, A. N. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.10.003 · Cited by 91 · see citing works

Probability and Statistical Inference

Kalbfleisch, J. G. (1985) · Springer texts in statistics · doi:10.1007/978-1-4612-1096-2 · Cited by 73 · see citing works

Replicative senescence and the art of counting

von Zglinicki, T. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.015 · Cited by 68 · see citing works

Mathematical modeling confirms the length-dependency of telomere shortening

den Buijs, J. O., van den Bosch, P. P. J., Musters, M., & van Riel, N. A. W. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.03.007 · Cited by 55 · see citing works

Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients

Kurosaka, D., Yasuda, J., Yoshida, K., Yokoyama, T., Ozawa, Y., Obayashi, Y., Kingetsu, I., Saitô, S., & Yamada, A. (2003) · Lupus · doi:10.1191/0961203303lu426oa · Cited by 43 · see citing works

Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing

Mariani, E. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00058-5 · Cited by 43 · see citing works

Atherogenesis in rheumatology

van Leuven, S. I., Kastelein, J. J. P., D’Cruz, D. P., Hughes, G. R. V., & Stroes, E. S. G. (2006) · Lupus · doi:10.1191/0961203306lu2273rr · Cited by 36 · see citing works

Impact of the Hayflick Limit on T cell responses to infection: lessons from aging and HIV disease

Effros, R. B. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.11.003 · Cited by 25 · see citing works

Telomeres and early-life stress: an overview

Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339 · see citing works

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging

Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works

Meta-analysis of Telomere Length in Alzheimer’s Disease

Forero, D. A., González-Giraldo, Y., López-Quintero, C., Castro-Vega, L. J., Barreto, G. E., & Perry, G. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw053 · Cited by 229 · see citing works

Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis

Valdes, A. M., Richards, J. B., Gardner, J. P., Swaminathan, R., Kimura, M., Xiaobin, L., Aviv, A., & Spector, T. D. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0357-5 · Cited by 164 · see citing works

Accelerated Telomere Attrition Is Associated with Relative Household Income, Diet and Inflammation in the pSoBid Cohort

Shiels, P. G., McGlynn, L. M., MacIntyre, A., Johnson, P. C. D., Batty, G. D., Burns, H., Cavanagh, J., Deans, K. A., Ford, I., McConnachie, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022521 · Cited by 143 · see citing works

Beginning at the ends: telomeres and human disease

Savage, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14068.1 · Cited by 124 · see citing works

Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins

Ludlow, A. T., Ludlow, L. W., & Roth, S. M. (2013) · BioMed Research International · doi:10.1155/2013/601368 · Cited by 93 · see citing works

Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores

Teyssier, J.-R., Chauvet-Gelinier, J.-C., Ragot, S., & Bonin, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049677 · Cited by 73 · see citing works

Association of relative telomere length with progression of chronic kidney disease in two cohorts: effect modification by smoking and diabetes

Raschenberger, J., Kollerits, B., Ritchie, J., Lane, B., Kalra, P. A., Ritz, E., & Kronenberg, F. (2015) · Scientific Reports · doi:10.1038/srep11887 · Cited by 66 · see citing works

No association between mean telomere length and life stress observed in a 30 year birth cohort

Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097102 · Cited by 62 · see citing works

TRF1 is a critical trans-acting factor required for de novo telomere formation in human cells

Okabe, J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.18.2639 · Cited by 35 · see citing works

Molecular Manifestations and Molecular Determinants of Telomere CappingPreprint

Blackburn, E. H., Chan, S. R. W. L., Chang, J., Fulton, T. B., Krauskopf, A., McEachern, M. J., Prescott, J. C., Roy, J., Smith, C. J., & WANG, H. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.253 · Cited by 70 · see citing works

Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics

Seimiya, H., Muramatsu, Y., Ohishi, T., & Tsuruo, T. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.021 · Cited by 166 · see citing works

Analysis of Telomere Length and Telomerase Activity

Hathcock, K. S., Hodes, R. J., & Weng, N. (2004) · Current Protocols in Immunology · doi:10.1002/0471142735.im1030s62 · Cited by 20 · see citing works

[Relationship between telomere length and clinical and biological characteristics of the cancers with telomerase reactivation].

Hiyama, E., Yokoyama, T., Hiyama, K., et al. (1998) · PubMed · Cited by 3 · see citing works