Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective
Open accessAbstract
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally. They have been tightly linked to microbiome taxonomic and functional composition, with diet possibly mediating some of the associations described. Both the microbiome and diet are modifiable, which opens the way for novel therapeutic strategies. High-throughput omics techniques applied on microbiome samples (meta-omics) hold the unprecedented potential to shed light on the intricate links between diet, the microbiome, the metabolome and cardiometabolic health, with a top-down approach. However, effective integration of complementary meta-omic techniques is an open challenge and their application on large cohorts is still limited. Here we review meta-omics techniques and discuss their potential in this context, highlighting recent large-scale efforts and the novel insights they provided. Finally, we look to the next decade of meta-omics research and discuss various translational and clinical pathways to improving cardiometabolic health.
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Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods.
“Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods. 35-41”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [41]
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Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome.
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Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost Trial
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- Authors
- Valles-Colomer, M., Menni, C., Berry, S. E., Valdes, A. M., Spector, T. D., & Segata, N.
- Affiliations
- King's College London (GB)
- University of Nottingham (GB)
- University of Trento (IT)
- Corresponding author
- Segata, Nicola
- ORCID
- Venue
- Nature Medicine
- Published
- 2023-03
- Volume
- 29
- Issue
- 3
- Pages
- 551-561
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC11258867
- OpenAlex
- W4327713018
- Cited by
- 114
- References
- 144
- Citations by year
- 2026: 39 · 2025: 41 · 2024: 23 · 2023: 11
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Funders
- European Commission (716575, 964590, 825410, 101045015, HORIZON2020, 818368)
- National Institutes of Health (1u01ca230551-01a1, 1U01CA230551)
- National Cancer Institute (1U01CA230551, U01 CA230551, R01CA230551)
- NextGenerationEU
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- cardiometabolic health, cardiometabolic disease, gut microbiota, diet, meta-omics, metabolome, multi-omics integration, clinical translation, treatment options
- MeSH terms
- Gastrointestinal Microbiome, Cardiovascular Diseases, Diet, Humans, Metabolomics, Metabolome
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