Cited by 114Gut microbiota and healthNutrition, Genetics, and DiseaseNutritional Studies and Diet

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

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Valles-Colomer, Mireia, Menni, Cristina, Berry, Sarah E., Valdes, Ana M., Spector, Tim D., Segata, Nicola·2023·Nature Medicine

Abstract

Cardiometabolic diseases have become a leading cause of morbidity and mortality globally. They have been tightly linked to microbiome taxonomic and functional composition, with diet possibly mediating some of the associations described. Both the microbiome and diet are modifiable, which opens the way for novel therapeutic strategies. High-throughput omics techniques applied on microbiome samples (meta-omics) hold the unprecedented potential to shed light on the intricate links between diet, the microbiome, the metabolome and cardiometabolic health, with a top-down approach. However, effective integration of complementary meta-omic techniques is an open challenge and their application on large cohorts is still limited. Here we review meta-omics techniques and discuss their potential in this context, highlighting recent large-scale efforts and the novel insights they provided. Finally, we look to the next decade of meta-omics research and discuss various translational and clinical pathways to improving cardiometabolic health.

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  1. [2]National Academies of Sciences, Engineering, and Medicine in High and Rising Mortality Rates Among Working-Age Adults Ch. 9 (National Academies Press, 2021). 33656826
  2. [36]Van de Wiele T, Van den Abbeele P, Ossieur W, Possemiers S & Marzorati M in The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models 305– 317 (Springer International Publishing, 2015).
  3. [78]Clarke RJ Coffee: Chemistry Vol. 1 (Springer Science & Business Media, 2012).

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Authors
Valles-Colomer, M., Menni, C., Berry, S. E., Valdes, A. M., Spector, T. D., & Segata, N.
Affiliations
  • King's College London (GB)
  • University of Nottingham (GB)
  • University of Trento (IT)
Corresponding author
Segata, Nicola
Venue
Nature Medicine
Published
2023-03
Volume
29
Issue
3
Pages
551-561
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W4327713018
Cited by
114
References
144
Citations by year
2026: 39 · 2025: 41 · 2024: 23 · 2023: 11
FWCI
3.04
Type
journal article
Language
en
Open access
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (cc-by)
Funders
  • European Commission (716575, 964590, 825410, 101045015, HORIZON2020, 818368)
  • National Institutes of Health (1u01ca230551-01a1, 1U01CA230551)
  • National Cancer Institute (1U01CA230551, U01 CA230551, R01CA230551)
  • NextGenerationEU
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
cardiometabolic health, cardiometabolic disease, gut microbiota, diet, meta-omics, metabolome, multi-omics integration, clinical translation, treatment options
MeSH terms
Gastrointestinal Microbiome, Cardiovascular Diseases, Diet, Humans, Metabolomics, Metabolome

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