Steinmetz, Lars M.

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 2,132

Assembly of functionally integrated human forebrain spheroids

Birey, F., Andersen, J., Makinson, C. D., Islam, S., Wei, W., Huber, N., Fan, H. C., Metzler, K. R. C., Panagiotakos, G., Thom, N., et al. (2017) · Nature

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 1,365

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 1,240

Human haematopoietic stem cell lineage commitment is a continuous process

Velten, L., Haas, S. F., Raffel, S., Blaszkiewicz, S., Islam, S., Hennig, B. P., Hirche, C., Lutz, C., Buss, E. C., Nowak, D., et al. (2017) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 925

Role of duplicate genes in genetic robustness against null mutations

Gu, Z., Steinmetz, L. M., Gu, X., Scharfe, C., Davis, R. W., & Li, W.-H. (2003) · Nature

Evolution and Genetic DynamicsFungal and yeast genetics research

Cited by 889

Evolutionary Rate in the Protein Interaction Network

Fraser, H. B., Hirsh, A. E., Steinmetz, L. M., Scharfe, C., & Feldman, M. W. (2002) · Science

Evolution and Genetic DynamicsBioinformatics and Genomic Networks

Cited by 869

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

Zuo, E., Sun, Y., Wei, W., Yuan, T., Ying, W., Sun, H., Yuan, L., Steinmetz, L. M., Li, Y., & Yang, H. (2019) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 782

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Tay, T. L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., et al. (2017) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 597

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, Á. M., Schnell, A., Hexel, K., et al. (2015) · Cell Stem Cell

Platelet Disorders and TreatmentsHematopoietic Stem Cell Transplantation

Cited by 471

Transcriptional regulation and function during the human cell cycle

Cho, R. J., Huang, M., Campbell, M. J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S. J., Davis, R. W., & Lockhart, D. J. (2001) · Nature Genetics

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 455

Extensive Variation in Chromatin States Across Humans

Kasowski, M., Kyriazopoulou-Panagiotopoulou, S., Grubert, F., Zaugg, J. B., Kundaje, A., Liu, Y., Boyle, A. P., Zhang, Q. C., Zakharia, F., Spacek, D. V., et al. (2013) · Science

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 339

Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions

Grubert, F., Zaugg, J. B., Kasowski, M., Ursu, O., Spacek, D. V., Martin, A. R., Greenside, P., Srivas, R., Phanstiel, D. H., Pekowska, A., et al. (2015) · Cell

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 319

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

Miller, C. N., Proekt, I., von Moltke, J., Wells, K. L., Rajpurkar, A. R., Wang, H., Rattay, K., Khan, I. S., Metzger, T. C., Pollack, J. L., et al. (2018) · Nature

T-cell and B-cell ImmunologyIon Channels and Receptors

Cited by 289

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Li, J., Zaslavsky, M., Su, Y., Guo, J., Sikora, M. J., van Unen, V., Christophersen, A., Chiou, S.-H., Chen, L., Li, J., et al. (2022) · Science

T-cell and B-cell ImmunologyImmune Cell Function and Interaction

Cited by 249

Targeted Perturb-seq enables genome-scale genetic screens in single cells

Schraivogel, D., Gschwind, A. R., Milbank, J. H., Leonce, D. R., Jakob, P., Mathur, L., Korbel, J. O., Merten, C. A., Velten, L., & Steinmetz, L. M. (2020) · Nature Methods

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 245

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

Gudipati, R. K., Xu, Z., Lebreton, A., Séraphin, B., Steinmetz, L. M., Jacquier, A., & Libri, D. (2012) · Molecular Cell

RNA Research and SplicingRNA regulation and disease

Cited by 236

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

Mall, M., Kareta, M. S., Chanda, S., Ahlenius, H., Perotti, N., Zhou, B., Grieder, S. D., Ge, X., Drake, S., Euong Ang, C., et al. (2017) · Nature

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 225

Biological plasticity rescues target activity in CRISPR knock outs

Smits, A. H., Ziebell, F., Joberty, G., Zinn, N., Mueller, W. F., Clauder-Münster, S., Eberhard, D., Fälth Savitski, M., Grandi, P., Jakob, P., et al. (2019) · Nature Methods

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 219

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D

Perocchi, F., Xu, Z., Clauder-Münster, S., & Steinmetz, L. M. (2007) · Nucleic Acids Research

Cancer-related molecular mechanisms researchGenomics and Phylogenetic Studies

Cited by 193

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Gschwind, A. R., Mualim, K. S., Karbalayghareh, A., Sheth, M. U., Dey, K. K., Jagoda, E., Nurtdinov, R. N., Xi, W., Tan, A. S., Jones, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 119

Alternative polyadenylation diversifies post‐transcriptional regulation by selective RNA–protein interactions

Gupta, I., Clauder‐Münster, S., Klaus, B., Järvelin, A. I., Aiyar, R. S., Benes, V., Wilkening, S., Huber, W., Pelechano, V., & Steinmetz, L. M. (2014) · Molecular Systems Biology

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 95

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

Chen, Y., Pai, A. A., Herudek, J., Lubas, M., Meola, N., Järvelin, A. I., Andersson, R., Pelechano, V., Steinmetz, L. M., Jensen, T. H., et al. (2016) · Nature Genetics

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 78

A Genome-Wide Map of Mitochondrial DNA Recombination in Yeast

Fritsch, E. S., Chabbert, C. D., Klaus, B., & Steinmetz, L. M. (2014) · Genetics

Fungal and yeast genetics researchDNA Repair Mechanisms

Cited by 77

Gain of CTCF-Anchored Chromatin Loops Marks the Exit from Naive Pluripotency

Pękowska, A., Klaus, B., Xiang, W., Severino, J., Daigle, N., Klein, F. A., Oleś, M., Casellas, R., Ellenberg, J., Steinmetz, L. M., et al. (2018) · Cell Systems

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 74