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Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response

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Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction

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Jumonji C Demethylases in Cellular Senescence

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A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives

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Mitochondrial Damage Induces Senescence with a Twisted Arm

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Exploiting senescence for the treatment of cancer

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Senescence and cancer — role and therapeutic opportunities

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Cellular senescence: a key therapeutic target in aging and diseases

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Strategies for targeting senescent cells in human disease

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Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes

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Immune ageing at single-cell resolution

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Guidelines for minimal information on cellular senescence experimentation in vivo

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Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

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The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?

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p21 produces a bioactive secretome that places stressed cells under immunosurveillance

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The heterogeneity of cellular senescence: insights at the single-cell level

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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

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P16INK4A—More Than a Senescence Marker

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Senescence as a therapeutic target in cancer and age-related diseases

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Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

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An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

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Senescence and the tumor-immune landscape: Implications for cancer immunotherapy

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Identifying specific functional roles for senescence across cell types

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Cellular senescence: Neither irreversible nor reversible

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Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies

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Role of cellular senescence in inflammation and regeneration

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Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy

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Angiodiversity and organotypic functions of sinusoidal endothelial cells

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Influence of the Mediterranean Diet on Healthy Aging

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Emerging insights in senescence: pathways from preclinical models to therapeutic innovations

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Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1

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Cellular senescence and kidney aging

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Discovering small-molecule senolytics with deep neural networks

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Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models

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Senescent cells as promising targets to tackle age-related diseases

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Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy

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Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies

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Capillarized Liver Sinusoidal Endothelial Cells Undergo Partial Endothelial-Mesenchymal Transition to Actively Deposit Sinusoidal ECM in Liver Fibrosis

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Quantitative mapping of human hair greying and reversal in relation to life stress

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Aging microenvironment and antitumor immunity for geriatric oncology: the landscape and future implications

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Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging

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Ageing, cellular senescence and chronic kidney disease: experimental evidence

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Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

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Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction

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Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity

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Cellular senescence in the tumor microenvironment and context‐specific cancer treatment strategies

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A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice

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Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration

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Immune surveillance of senescence: potential application to age-related diseases

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Current Methodological Challenges of Single-Cell and Single-Nucleus RNA-Sequencing in Glomerular Diseases

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Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7

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Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart

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Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

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Mid-old cells are a potential target for anti-aging interventions in the elderly

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Death-seq identifies regulators of cell death and senolytic therapies

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Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization

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Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion

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Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue

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Senescence in cancer: Advances in detection and treatment modalities

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Chronic social stress induces p16-mediated senescent cell accumulation in mice

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CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

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Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

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Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers

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Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review

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M2 macrophage-derived TGF-β induces age-associated loss of adipogenesis through progenitor cell senescence

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Cellular senescence induction leads to progressive cell death via the INK4a‐RB pathway in naked mole‐rats

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Integrative analysis of senescence-related genes identifies robust prognostic clusters with distinct features in hepatocellular carcinoma

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Cellular senescence primes liver fibrosis regression through Notch‐EZH2

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p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries

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Liver sinusoidal endothelial cells: Friend or foe in metabolic dysfunction- associated steatotic liver disease/metabolic dysfunction-associated steatohepatitis

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Senescent AECⅡ and the implication for idiopathic pulmonary fibrosis treatment

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Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of alveolar macrophages

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Senescence and senolysis in cancer: The latest findings

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Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche

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Autophagy and senescence, converging roles in pathophysiology as seen through mouse models

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Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks

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Senescence and fibrosis in salivary gland aging and disease

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Senolytic Prodrugs: A Promising Approach to Enhancing Senescence‐Targeting Intervention

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UBE2E3 regulates cellular senescence and osteogenic differentiation of BMSCs during aging

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A p21-ATD mouse model for monitoring and eliminating senescent cells and its application in liver regeneration post injury

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Senescence in cancer: Hallmarks, paradoxes, and therapeutic promise

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Recent Advances in Senolysis for Age-Related Diseases

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Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells

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Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence

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Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship

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Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice

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Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies

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Stromal senescence contributes to age-related increases in cancer

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Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver‐derived TNF‐α in senescence‐accelerated mice

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Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies

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Distribution and impact of p16INK4A+ senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction

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Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment

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Dasatinib and Quercetin as Senolytic Drugs Improve Fat Deposition and Exhibit Antifibrotic Effects in the Medaka Metabolic Dysfunction-Associated Steatotic Liver Disease Model

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Transcriptomic characterization of Lonrf1 at the single-cell level under pathophysiological conditions

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Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission

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A senolytic immunotoxin eliminates p16-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse

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In vivo dynamics of senescence in rhabdomyolysis-induced acute kidney injury

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Detecting cellular senescence in vivo: Imagining imaging better

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Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship

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Characterizing primary and secondary senescence in vivo

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Nanomaterials intervene in cell senescence to reinforce cancer therapy

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Cellular senescence in kidney diseases

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p16 Vivo‐Morpholino Treatment Attenuates Hepatic Senescence and Non‐Alcoholic Fatty Liver Disease Phenotypes in a Diet‐Induced Rodent Model

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Response to: Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells

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A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis

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Selective ablation of p16Ink4a-lineage hepatocytes attenuates hepatic steatosis in diet-induced MASH

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The SenKiller Mouse: Enabling Cell Type–Specific Ablation of Senescent Cells

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