The two-component response regulator Ssk1 and the mitogen-activated protein kinase Hog1 control antifungal drug resistance and cell wall architecture of Candida auris
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Candida auris is an emerging multidrug-resistant (MDR) fungal pathogen that presents a serious global threat to human health. The Centers for Disease Control and Prevention (CDC) have classified C. auris as an urgent threat to public health for the next decade due to its major clinical and economic impact and the lack of effective antifungal drugs and because of future projections concerning new C. auris infections. Importantly, the Global Antimicrobial Resistance Surveillance System (GLASS) has highlighted the need for more robust and efficacious global surveillance schemes enabling the identification and monitoring of antifungal resistance in Candida infections. Despite the clinical relevance of C. auris infections, our overall understanding of its pathophysiology and virulence, its response to human immune surveillance, and the molecular basis of multiple antifungal resistance remains in its infancy. Here, we show a marked phenotypic plasticity of C. auris clinical isolates. Further, we demonstrate critical roles of stress response mechanisms in regulating multidrug resistance and show that cell wall architecture and composition are key elements that determine antifungal drug susceptibilities. Our data promise new therapeutic options to treat drug-refractory C. auris infections.
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C. auris Hog1 is required for antifungal drug resistance.
“Previously, we showed that C. auris Hog1 is required for antifungal drug resistance (40).”
From The <i>Candida auris</i> Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence (2024) · cites this paper as [40]
The Candida auris strains 1184/P/15 and hog1Δ used in this study were described previously.
“The Candida auris strains 1184/P/15 and hog1Δ used in this study were described previously (40).”
From The <i>Candida auris</i> Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence (2024) · cites this paper as [40]
C. auris Hog1 has previously been reported to be important for antifungal drug resistance, stress response, and virulence in a Caenorhabditis elegans model of infection.
“The C. auris Hog1 has previously been reported to be important for antifungal drug resistance, stress response, and was also shown to be important for virulence in a Caenorhabditis elegans model of infection (39, 40).”
From The <i>Candida auris</i> Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence (2024) · cites this paper as [40]
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Transcriptional and translational landscape of <i>Candida auris</i> in response to caspofungin
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Native human and mouse skin infection models to study Candida auris-host interactions
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Self-citationEvolutionary accumulation of FKS 1 mutations from clinical echinocandin-resistant Candida auris
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Raman Metabolomics of Candida auris Clades: Profiling and Barcode Identification
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Uniqueness of Candida auris cell wall in morphogenesis, virulence, resistance, and immune evasion
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“The cell wall components were quantified by using a flow cytometry-based approach as described previously (40).”
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Comparative fitness trade-offs associated with azole resistance in Candida auris clinical isolates
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Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida
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Candida auris : host interactions, antifungal drug resistance, and diagnostics
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Self-citationStress contingent changes in Hog1 pathway architecture and regulation in Candida albicans
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Octenidine effectively reduces Candida auris colonisation on human skin
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Self-citationPost-transcriptional control of antifungal resistance in human fungal pathogens
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The high-osmolarity glycerol (HOG) pathway in Candida auris
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Pathogenicity and virulence of Candida auris
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Senolytic drugs: implications for clinical practice
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Carbon Dioxide Controls Fungal Fitness and Skin Tropism of Candida aurisPreprint
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Cytochrome <i>bc1</i> Catalytic Subunit Rip1 Modulates Antifungal Tolerance in <i>Candida auris</i>
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Candidozyma auris ( Candida auris ) as a harbinger of novel fungal pathogens
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- Authors
- Shivarathri, R., Jenull, S., Stoiber, A., Chauhan, M., Mazumdar, R., Singh, A., Nogueira, F., Kuchler, K., Chowdhary, A., & Chauhan, N.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Max Perutz Labs (AT)
- University of Delhi (IN)
- Corresponding author
- Kuchler, Karl
- Chowdhary, Anuradha
- Chauhan, Neeraj
- ORCID
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2020-10-28
- Volume
- 5
- Issue
- 5
- ISSN
- 2379-5042 (ISSN-L)
- PMC
- PMC7565899
- OpenAlex
- W3092887456
- Cited by
- 59
- References
- 76
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 10
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSphere (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- HHS | National Institutes of Health (R01AI124499)
- New Jersey Health Foundation (PC40-18)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida auris, antifungal resistance, multidrug resistance, cell wall architecture, cell wall composition, stress response, phenotypic plasticity, antifungal susceptibility, emerging fungal pathogens
- MeSH terms
- Adaptation, Physiological, Antifungal Agents, Candida, Candidiasis, Cell Wall, Fungal Proteins, Humans, Microbial Sensitivity Tests, Virulence, Mitogen-Activated Protein Kinases, Drug Resistance, Multiple, Fungal
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