Nicholson, Jeremy K.

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science

Gut microbiota and healthAnimal Nutrition and Physiology

Cited by 4,760

OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification

Bylesjö, M., Rantalainen, M., Cloarec, O., Nicholson, J. K., Holmes, E., & Trygg, J. (2006) · Journal of Chemometrics

Spectroscopy and Chemometric AnalysesStatistical Methods and Applications

Cited by 1,475

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E. (2016) · Genome Medicine

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,438

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science

Gut microbiota and healthChild Nutrition and Water Access

Cited by 1,173

Symbiotic gut microbes modulate human metabolic phenotypes

Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., et al. (2008) · Proceedings of the National Academy of Sciences

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 1,144

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,066

Human metabolic phenotype diversity and its association with diet and blood pressure

Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K. S., Chan, Q., Ebbels, T., De Iorio, M., Brown, I. J., Veselkov, K. A., et al. (2008) · Nature

Metabolomics and Mass Spectrometry StudiesNutrition, Genetics, and Disease

Cited by 1,054

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

Dumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences

Gut microbiota and healthDiet, Metabolism, and Disease

Cited by 1,042

Fat, fibre and cancer risk in African Americans and rural Africans

O’Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., et al. (2015) · Nature Communications

Gut microbiota and healthNutritional Studies and Diet

Cited by 982

Gut microbiota modulation of chemotherapy efficacy and toxicity

Alexander, J. L., Wilson, I. D., Teare, J., Marchesi, J. R., Nicholson, J. K., & Kinross, J. M. (2017) · Nature Reviews Gastroenterology & Hepatology

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 970

Gut microorganisms, mammalian metabolism and personalized health care

Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 945

Pharmaco-metabonomic phenotyping and personalized drug treatment

Andrew Clayton, T., Lindon, J. C., Cloarec, O., Antti, H., Charuel, C., Hanton, G., Provost, J.-P., Le Net, J.-L., Baker, D., Walley, R. J., et al. (2006) · Nature

Pharmacogenetics and Drug MetabolismMetabolomics and Mass Spectrometry Studies

Cited by 824

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., & Nicholson, J. K. (2009) · Proceedings of the National Academy of Sciences

Pharmacogenetics and Drug MetabolismGut microbiota and health

Cited by 765

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences

Gut microbiota and healthDrug Transport and Resistance Mechanisms

Cited by 726

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Hoyles, L., Fernández-Real, J.-M., Federici, M., Serino, M., Abbott, J., Charpentier, J., Heymes, C., Luque, J. L., Anthony, E., Barton, R. H., et al. (2018) · Nature Medicine

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 720

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

Wilson, I. D., & Nicholson, J. K. (2017) · Translational Research

Pharmacogenetics and Drug MetabolismGut microbiota and health

Cited by 656

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

Hoyles, L., Snelling, T., Umlai, U.-K., Nicholson, J. K., Carding, S. R., Glen, R. C., & McArthur, S. (2018) · Microbiome

Gut microbiota and healthBarrier Structure and Function Studies

Cited by 591

The gut microbiota influences skeletal muscle mass and function in mice

Lahiri, S., Kim, H., Garcia-Perez, I., Reza, M. M., Martin, K. A., Kundu, P., Cox, L. M., Selkrig, J., Posma, J. M., Zhang, H., et al. (2019) · Science Translational Medicine

Gut microbiota and healthMuscle Physiology and Disorders

Cited by 580

Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H., & Nicholson, J. K. (2011) · Trends in Microbiology

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 541

Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping

Dona, A. C., Jiménez, B., Schäfer, H., Humpfer, E., Spraul, M., Lewis, M. R., Pearce, J. T. M., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2014) · Analytical Chemistry

Metabolomics and Mass Spectrometry StudiesAdvanced NMR Techniques and Applications

Cited by 540

Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity

Mitra, A., MacIntyre, D. A., Lee, Y. S., Smith, A., Marchesi, J. R., Lehne, B., Bhatia, R., Lyons, D., Paraskevaidis, E., Li, J. V., et al. (2015) · Scientific Reports

Reproductive tract infections researchCervical Cancer and HPV Research

Cited by 498

Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

Holmes, E., Li, J. V., Marchesi, J. R., & Nicholson, J. K. (2012) · Cell Metabolism

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 490

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

Martin, F. J., Wang, Y., Sprenger, N., Yap, I. K. S., Lundstedt, T., Lek, P., Rezzi, S., Ramadan, Z., van Bladeren, P., Fay, L. B., et al. (2008) · Molecular Systems Biology

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 421

Colonization-induced host-gut microbial metabolic interaction

Claus, S. P., Ellero, S. L., Berger, B., Krause, L., Bruttin, A., Molina, J., Paris, A., Want, E. J., de Waziers, I., Cloarec, O., et al. (2011) · mBio

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 414