Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
Open accessAbstract
The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing new personalized therapies and clinical management strategies.
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Many molecules in foods are substrates for the intestinal microbiota, which produce small molecules that after liver metabolism affect host physiology.
“many molecules in foods are substrates for the intestinal microbiota, which then produce small molecules that, after metabolism in the liver, affect host physiology (Figure 2)53.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [53]
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- Authors
- Holmes, E., Li, J. V., Marchesi, J. R., & Nicholson, J. K.
- Affiliations
- Imperial College London (GB)
- Cardiff University (GB)
- Corresponding author
- Nicholson, Jeremy K.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 16
- Issue
- 5
- Pages
- 559-564
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2085370071
- Cited by
- 490
- References
- 26
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 32 · 2023: 45 · 2022: 41 · 2021: 60 · 2020: 39 · 2019: 43 · 2018: 36 · 2017: 33 · 2016: 35 · 2015: 36 · 2014: 38 · 2013: 16 · 2012: 1
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, microbiota composition, disease risk, host-microbe interactions, personalized treatment, immune regulation, metabolic regulation
- MeSH terms
- Animals, Bacteria, Diet, Gastrointestinal Diseases, Humans, Phenotype, Bacterial Physiological Phenomena, Gastrointestinal Tract, Biodiversity, Metagenome, Metagenomics
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