The gut microbiota influences skeletal muscle mass and function in mice
Open accessAbstract
Transplanting the gut microbiota of pathogen-free mice into germ-free mice improves skeletal muscle mass and strength.
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The gut microbiota sends signals to the CNS and enteric nervous system through different pathways through metabolites, hormones, the immune system and afferent nerves.
“The gut microbiota sends signals to the CNS and enteric nervous system through different pathways through metabolites, hormones, the immune system and afferent nerves.14,15”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [15]
The Introduction says the gut microbiota influences immunity and behavior, and the Discussion describes microbial metabolites mediating host interactions. Neither passage says that the microbiota signals to the central and enteric nervous systems through metabolites, hormones, immune pathways, and afferent nerves. Searches for those nervous-system targets and pathways found no passage establishing the claim. (LLM, conf=0.72)
Experimental — accuracy not yet measuredThe gut microbiota generates metabolites including glycine, alanine, and choline that can positively regulate muscle mass, and germ-free mice show increased plasma glucocorticoids, decreased IGF1 and PGC1α expression, altered mitochondrial function, and induction of catabolic enzymes for BCAAs leading to poor quality muscles.
“The gut microbiota generates several metabolites including amino acids like glycine and alanine and the neurotransmitter precursor choline that can positively regulate muscle mass. Indeed, germ-free mice show an increased plasma level of glucocorticoids, decreased IGF1 and PGC1α expression, alteration of mitochondrial function, and induction of catabolic enzymes for branched-chain amino acids (BCA”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [36]
The gut microbiota plays an important role in maintaining host physiology homeostasis by regulating multiple processes, including nutrient absorption, inflammation, oxidative stress, immune function, and anabolic balance.
“Besides, the gut microbiota plays an important role in maintaining host physiology homeostasis by regulating multiple processes, including nutrient absorption, inflammation, oxidative stress, immune function, and anabolic balance.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [166]
Gut microbiota and their metabolites (e.g., short-chain fatty acids) are likely to engage multiple converging pathways to regulate host muscle growth and function.
“Gut microbiota and their metabolites (e.g., short-chain fatty acids) are likely to engage multiple converging pathways to regulate host muscle growth and function [166].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [166]
When transplanting the gut microbiota from pathogen-free mice into germ-free mice, the skeletal muscle atrophy markers are significantly reduced, and the skeletal muscle mass and oxidative metabolic capacity are improved in C57BL/6J male mice.
“However, when transplanting the gut microbiota from pathogen-free mice into germ-free mice, the skeletal muscle atrophy markers are significantly reduced, and the skeletal muscle mass and oxidative metabolic capacity are improved in C57BL/6J male mice [166], suggesting that gut microbiota may serve an essential role in preventing muscle atrophy.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [166]
The expression of MAFbx and MuRF-1 is upregulated in germ-free mice compared to pathogen-free mice.
“Lahiri et al. found that the expression of MAFbx and MuRF-1 is upregulating in germ-free mice compared to pathogen-free mice.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [166]
Gut microbiota may serve an essential role in preventing muscle atrophy.
“However, when transplanting the gut microbiota from pathogen-free mice into germ-free mice, the skeletal muscle atrophy markers are significantly reduced, and the skeletal muscle mass and oxidative metabolic capacity are improved in C57BL/6J male mice [166], suggesting that gut microbiota may serve an essential role in preventing muscle atrophy.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [166]
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- Authors
- Lahiri, S., Kim, H., Garcia-Perez, I., Reza, M. M., Martin, K. A., Kundu, P., Cox, L. M., Selkrig, J., Posma, J. M., Zhang, H., Padmanabhan, P., Moret, C., Gulyás, B., Blaser, M. J., Auwerx, J., Holmes, E., Nicholson, J., Wahli, W., & Pettersson, S.
- Affiliations
- Karolinska Institutet (SE)
- Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
- Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.
- Nanyang Technological University (SG)
- Brigham and Women's Hospital (US)
- Imperial College London (GB)
- Ministry of Education of the People's Republic of China (CN)
- University of Lausanne (CH)
- VA NY Harbor Healthcare System (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Murdoch University (AU)
- Corresponding author
- Lahiri, Shawon
- Pettersson, Sven
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-07-24
- Volume
- 11
- Issue
- 502
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7501733
- OpenAlex
- W2963465565
- Cited by
- 580
- References
- 50
- Citations by year
- 2026: 91 · 2025: 103 · 2024: 114 · 2023: 90 · 2022: 78 · 2021: 58 · 2020: 38 · 2019: 7
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Murdoch University Research Portal (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Medical Research Council (MR/S004033/1)
- Swiss National Science Foundation (P300P3_151157)
- Vetenskapsrådet
- European Society for Clinical Nutrition and Metabolism
- NIHR (NIHR-CDF-2017-10-032)
- TORNADO
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- gut microbiota, skeletal muscle mass, muscle function, short-chain fatty acids, microbial metabolites, germ-free mice, muscle atrophy
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cell Line, Germ-Free Life, Insulin-Like Growth Factor I, Liver, Male, Mice, Inbred C57BL, Muscle, Skeletal, Mice, Metabolomics
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