Muzyczka, Nicholas

Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S., Williams, P., Zolotukhin, S., Reier, P. J., Mandel, R. J., & Muzyczka, N. (2004) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 741

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

Zhong, L., Li, B., Mah, C. S., Govindasamy, L., Agbandje-McKenna, M., Cooper, M., Herzog, R. W., Zolotukhin, I., Warrington, K. H., Weigel-Van Aken, K. A., et al. (2008) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 558

Cloning of adeno-associated virus into pBR322: Rescue of intact virus from the recombinant plasmid in human cells

Samulski, R. J., Berns, K. I., Tan, M., & Muzyczka, N. (1982) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 466

Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding

Opie, S. R., Warrington, Agbandje-McKenna, M., Zolotukhin, S., & Muzyczka, N. (2003) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 364

Adeno-associated virus general transduction vectors: analysis of proviral structures

McLaughlin, S. K., Collis, P., Hermonat, P. L., & Muzyczka, N. (1988) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 348

Rescue of adeno-associated virus from recombinant plasmids: Gene correction within the terminal repeats of AAV

Samulski, R. J., Srivastava, A., Berns, K. I., & Muzyczka, N. (1983) · Cell

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 297

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

Zhong, L., Li, B., Jayandharan, G., Mah, C. S., Govindasamy, L., Agbandje-McKenna, M., Herzog, R. W., Weigel-Van Aken, K. A., Hobbs, J. A., Zolotukhin, S., et al. (2008) · Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 232

Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

Peden, C. S., Burger, C., Muzyczka, N., & Mandel, R. J. (2004) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 222

Structural insight into the unique properties of adeno-associated virus serotype 9

DiMattia, M. A., Nam, H.-J., Van Vliet, K., Mitchell, M., Bennett, A., Gurda, B. L., McKenna, R., Olson, N. H., Sinkovits, R. S., Potter, M., et al. (2012) · Journal of Virology

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 219

Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation

Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., et al. (2010) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 213

Structurally mapping the diverse phenotype of adeno-associated virus serotype 4

Govindasamy, L., Padron, E., McKenna, R., Muzyczka, N., Kaludov, N., Chiorini, J. A., & Agbandje-McKenna, M. (2006) · Journal of Virology

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 205

Adeno-Associated Virus Type 2 VP2 Capsid Protein Is Nonessential and Can Tolerate Large Peptide Insertions at Its N Terminus

Warrington, K. H., Gorbatyuk, O. S., Harrison, J. K., Opie, S. R., Zolotukhin, S., & Muzyczka, N. (2004) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 205

Factors that bind to adeno-associated virus terminal repeats

Im, D. S., & Muzyczka, N. (1989) · Journal of Virology

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 157

Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer

Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M. (1999) · Brain Research

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 128

Capsid antibodies to different adeno-associated virus serotypes bind common regions

Gurda, B. L., DiMattia, M. A., Miller, E. B., Bennett, A., McKenna, R., Weichert, W. S., Nelson, C. D., Chen, W.-J., Muzyczka, N., Olson, N. H., et al. (2013) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 127

Time Course of Transgene Expression After Intrastriatal Pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 Transduction in the Rat

Reimsnider, S., Manfredsson, F. P., Muzyczka, N., & Mandel, R. J. (2007) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 125

Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats

Ryan, J. H., Zolotukhin, S., & Muzyczka, N. (1996) · Journal of Virology

Virus-based gene therapy researchGenomics and Chromatin Dynamics

Cited by 119

Heparin binding induces conformational changes in Adeno-associated virus serotype 2

Levy, H. C., Bowman, V. D., Govindasamy, L., McKenna, R., Nash, K., Warrington, K., Chen, W., Muzyczka, N., Yan, X., Baker, T. S., et al. (2009) · Journal of Structural Biology

Virus-based gene therapy researchEnzyme Structure and Function

Cited by 110

Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking

Nam, H.-J., Gurda, B. L., McKenna, R., Potter, M., Byrne, B., Salganik, M., Muzyczka, N., & Agbandje-McKenna, M. (2011) · Journal of Virology

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 108

Structural insights into adeno-associated virus serotype 5

Govindasamy, L., DiMattia, M. A., Gurda, B. L., Halder, S., McKenna, R., Chiorini, J. A., Muzyczka, N., Zolotukhin, S., & Agbandje-McKenna, M. (2013) · Journal of Virology

Virus-based gene therapy researchEnzyme Structure and Function

Cited by 95

Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

Ling, C., Wang, Y., Lu, Y., Wang, L., Jayandharan, G. R., Aslanidi, G. V., Li, B., Cheng, B., Ma, W., Lentz, T., et al. (2015) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 47

Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented

Peden, C. S., Manfredsson, F. P., Reimsnider, S. K., Poirier, A. E., Burger, C., Muzyczka, N., & Mandel, R. J. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 44

Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding

Gorbatyuk, O. S., Warrington, K. H., Gorbatyuk, M. S., Zolotukhin, I., Lewin, A. S., & Muzyczka, N. (2019) · Virus Research

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 18