AMP-activated Protein Kinase α2 Activity Is Not Essential for Contraction- and Hyperosmolarity-induced Glucose Transport in Skeletal Muscle
Open accessAbstract
To examine the role of AMP-activated protein kinase (AMPK) in muscle glucose transport, we generated muscle-specific transgenic mice (TG) carrying cDNAs of inactive alpha2 (alpha2i TG) and alpha1 (alpha1i TG) catalytic subunits. Extensor digitorum longus (EDL) muscles from wild type and TG mice were isolated and subjected to a series of in vitro incubation experiments. In alpha2i TG mice basal alpha2 activity was barely detectable, whereas basal alpha1 activity was only partially reduced. Known AMPK stimuli including 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR), rotenone (a Complex I inhibitor), dinitrophenol (a mitochondrial uncoupler), muscle contraction, and sorbitol (producing hyperosmolar shock) did not increase AMPK alpha2 activity in alpha2i TG mice, whereas alpha1 activation was attenuated by only 30-50%. Glucose transport was measured in vitro using isolated EDL muscles from alpha2i TG mice. AICAR- and rotenone-stimulated glucose transport was fully inhibited in alpha2i TG mice; however, the lack of AMPK alpha2 activity had no effect on contraction- or sorbitol-induced glucose transport. Similar to these observations in vitro, contraction-stimulated glucose transport, assessed in vivo by 2-deoxy-d-[(3)H]glucose incorporation into EDL, tibialis anterior, and gastrocnemius muscles, was normal in alpha2i TG mice. Thus, AMPK alpha2 activation is essential for some, but not all, insulin-independent glucose transport. Muscle contraction- and hyperosmolarity-induced glucose transport may be regulated by a redundant mechanism in which AMPK alpha2 is one of multiple signaling pathways.
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AMPK α2 KO and α2 KD and α2iTg mice have normal or only modest reductions in glucose uptake during contractions.
“AMPK α2 KO and α2 KD and α2iTg mice have normal or only modest reductions in glucose uptake during contractions [4,26,31,32,118-120].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [32]
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- Authors
- Fujii, N., Hirshman, M. F., Kane, E. M., Ho, R. C., Peter, L. E., Seifert, M. M., & Goodyear, L. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Goodyear, Laurie J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 280
- Issue
- 47
- Pages
- 39033-39041
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2005476526
- Cited by
- 177
- References
- 40
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 15 · 2015: 9 · 2014: 9 · 2013: 12 · 2012: 11
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK36836, P30DK036836)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-42238, R01AR045670, F32AR049662)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- AMPK, AMPKα2, AMPKα1, skeletal muscle glucose transport, muscle contraction, hyperosmolarity, sorbitol, insulin-independent glucose transport, AICAR, rotenone, dinitrophenol, 2-deoxyglucose uptake, extensor digitorum longus
- MeSH terms
- Aminoimidazole Carboxamide, Animals, Biological Transport, Active, Glucose, Mice, Transgenic, Multienzyme Complexes, Muscle Contraction, Osmolar Concentration, Recombinant Proteins, Ribonucleotides, Rotenone, Sorbitol, Signal Transduction, Mutagenesis, Site-Directed, Protein Serine-Threonine Kinases, Muscle, Skeletal, Mice, Rats, AMP-Activated Protein Kinases, In Vitro Techniques
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