CoChat
Sign Up
Cited by 151Birth, Development, and HealthGestational Diabetes Research and ManagementDiet, Metabolism, and Disease

Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring

Open access
Stanford, Kristin I., Lee, Min-Young, Getchell, Kristen M., So, Kawai, Hirshman, Michael F., Goodyear, Laurie J.·2015·Diabetes
DOI 10.2337/db13-1848PMC PMC4303966
Open this paper in CoChat — free account

Abstract

The intrauterine environment during pregnancy is a critical factor in the development of diabetes and obesity in offspring. To determine the effects of maternal exercise during pregnancy on the metabolic health of offspring, 6-week-old C57BL/6 virgin female mice were fed a chow (21%) or high-fat (60%) diet and divided into four subgroups: trained (housed with running wheels for 2 weeks preconception and during gestation), prepregnancy trained (housed with running wheels for 2 weeks preconception), gestation trained (housed with running wheels during gestation), or sedentary (static cages). Male offspring were chow fed, sedentary, and studied at 8, 12, 24, 36, and 52 weeks of age. Offspring from chow-fed dams that trained both before and during gestation had improved glucose tolerance beginning at 8 weeks of age and continuing throughout the 1st year of life, and at 52 weeks of age had significantly lower serum insulin concentrations and percent body fat compared with all other groups. High-fat feeding of sedentary dams resulted in impaired glucose tolerance, increased serum insulin concentrations, and increased percent body fat in offspring. Remarkably, maternal exercise before and during gestation ameliorated the detrimental effect of a maternal high-fat diet on the metabolic profile of offspring. Exercise before and during pregnancy may be a critical component for combating the increasing rates of diabetes and obesity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2337/db13-1848

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In offspring of high-fat diet fed dams, treadmill exercise improved the glucose tolerance of both male and female offspring.

    “In offspring of high-fat diet fed dams, treadmill exercise improved the glucose tolerance of both male and female offspring [134,135,136].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [134]

    The Results section on maternal high-fat feeding (Fig. 2A–B; page not provided) reports improved glucose tolerance in male offspring of exercise-trained dams. It does not establish the effect in female offspring. The same section describes the dams’ exercise as wheel running, not treadmill exercise. (LLM, conf=0.92)

    Experimental — accuracy not yet measured

  • In general, the most significant effects of maternal exercise on offspring metabolic health are observed when maternal exercise begins before mating and is continued throughout pregnancy.

    “In general, the most significant effects are observed when maternal exercise begins before mating and is continued throughout pregnancy.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [134]

    The Results section (page unavailable) compares exercise before and during gestation with exercise only before pregnancy or only during gestation. In male mouse offspring, the combined schedule produced lasting improvements in glucose tolerance, while the other schedules did not. The claim’s “in general” extends that finding beyond the population studied. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Several groups have shown that enforced maternal treadmill exercise or voluntary wheel running had significant effects on the metabolic health of male and female offspring.

    “Several groups have shown that enforced maternal treadmill exercise or voluntary wheel running had significant effects on the metabolic health of male and female offspring [131,132,133,134,135,136].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [134]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Stanford, K. I., Lee, M.-Y., Getchell, K. M., So, K., Hirshman, M. F., & Goodyear, L. J.
Affiliations
  • Brigham and Women's Hospital (US)
  • Joslin Diabetes Center (US)
Corresponding author
Goodyear, Laurie J.
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2014-09-09
Volume
64
Issue
2
Pages
427-433
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db13-1848
PMC
PMC4303966
OpenAlex
W2145925744
Cited by
151
References
34
Citations by year
2026: 12 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 18 · 2021: 17 · 2020: 18 · 2019: 10 · 2018: 10 · 2017: 16 · 2016: 11 · 2015: 10 · 2014: 1
FWCI
11.92
Type
journal article
Language
en
Open access
Licence
www.diabetesjournals.org/site/license (vor, 326 d)
Locations
  • Diabetes (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (5P30 DK36836, R01-DK101043)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR42238)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
exercise during pregnancy, maternal high-fat diet, offspring metabolic health, glucose tolerance, insulin resistance, fat mass, obesity, prenatal programming
MeSH terms
Animals, Blood Glucose, Dietary Fats, Female, Glucose, Insulin, Litter Size, Male, Mice, Inbred C57BL, Physical Conditioning, Animal, Pregnancy, Prenatal Exposure Delayed Effects, Sex Ratio, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review