Sharp, Phillip A.

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 4,302

In vivo genome editing using Staphylococcus aureus Cas9

Ran, F. A., Cong, L., Yan, W. X., Scott, D. A., Gootenberg, J. S., Kriz, A. J., Zetsche, B., Shalem, O., Wu, X., Makarova, K. S., et al. (2015) · Nature

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 2,687

Coactivator condensation at super-enhancers links phase separation and gene control

Sabari, B. R., Dall’Agnese, A., Boija, A., Klein, I. A., Coffey, E. L., Shrinivas, K., Abraham, B. J., Hannett, N. M., Zamudio, A. V., Manteiga, J. C., et al. (2018) · Science

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 2,595

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

Ebert, M. S., Neilson, J. R., & Sharp, P. A. (2007) · Nature Methods

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 2,108

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

Platt, R. J., Chen, S., Zhou, Y., Yim, M. J., Swiech, L., Kempton, H. R., Dahlman, J. E., Parnas, O., Eisenhaure, T. M., Jovanovic, M., et al. (2014) · Cell

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 2,001

A Phase Separation Model for Transcriptional Control

Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K., & Sharp, P. A. (2017) · Cell

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 1,753

Roles for MicroRNAs in Conferring Robustness to Biological Processes

Ebert, M. S., & Sharp, P. A. (2012) · Cell

MicroRNA in disease regulationDevelopmental Biology and Gene Regulation

Cited by 1,564

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 1,349

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,279

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science

Mesenchymal stem cell researchHippo pathway signaling and YAP/TAZ

Cited by 1,009

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

Yin, H., Xue, W., Chen, S., Bogorad, R. L., Benedetti, E., Grompe, M., Koteliansky, V., Sharp, P. A., Jacks, T., & Anderson, D. G. (2014) · Nature Biotechnology

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 951

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Wu, X., Scott, D. A., Kriz, A. J., Chiu, A. C., Hsu, P. D., Dadon, D. B., Cheng, A. W., Trevino, A. E., Konermann, S., Chen, S., et al. (2014) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 944

MicroRNA functions in stress responses

Leung, A. K. L., & Sharp, P. A. (2010) · Molecular Cell

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 865

CRISPR-mediated direct mutation of cancer genes in the mouse liver

Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N. S., Cai, W., Yang, G., Bronson, R., Crowley, D. G., et al. (2014) · Nature

CRISPR and Genetic EngineeringCancer Genomics and Diagnostics

Cited by 776

MicroRNA sponges: Progress and possibilities

Ebert, M. S., & Sharp, P. A. (2010) · RNA

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 762

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

Edbauer, D., Neilson, J. R., Foster, K. A., Wang, C.-F., Seeburg, D. P., Batterton, M. N., Tada, T., Dolan, B. M., Sharp, P. A., & Sheng, M. (2010) · Neuron

Genetics and Neurodevelopmental DisordersMicroRNA in disease regulation

Cited by 735

Transcription factor trapping by RNA in gene regulatory elements

Sigova, A. A., Abraham, B. J., Ji, X., Molinie, B., Hannett, N. M., Guo, Y. E., Jangi, M., Giallourakis, C. C., Sharp, P. A., & Young, R. A. (2015) · Science

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 492

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

Dimitrova, N., Zamudio, J. R., Jong, R. M., Soukup, D., Resnick, R., Sarma, K., Ward, A. J., Raj, A., Lee, J. T., Sharp, P. A., et al. (2014) · Molecular Cell

Cancer-related molecular mechanisms researchCancer-related Molecular Pathways

Cited by 445

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation

Dubbury, S. J., Boutz, P. L., & Sharp, P. A. (2018) · Nature

RNA Research and SplicingDNA Repair Mechanisms

Cited by 318

Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis

Suzuki, H. I., Young, R. A., & Sharp, P. A. (2017) · Cell

MicroRNA in disease regulationGenomics and Chromatin Dynamics

Cited by 284

Structure-Based Design of Transcription Factors

Pomerantz, J. L., Sharp, P. A., & Pabo, C. O. (1995) · Science

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 226

Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

McManus, M. T., Haines, B. B., Dillon, C. P., Whitehurst, C. E., van Parijs, L., Chen, J., & Sharp, P. A. (2002) · The Journal of Immunology

RNA Interference and Gene DeliveryRNA Research and Splicing

Cited by 215

MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1–regulated pathways in mice

Meenhuis, A., van Veelen, P. A., de Looper, H., van Boxtel, N., van den Berge, I. J., Sun, S. M., Taskesen, E., Stern, P., de Ru, A. H., van Adrichem, A. J., et al. (2011) · Blood

MicroRNA in disease regulationAcute Myeloid Leukemia Research

Cited by 142

Building Robust Transcriptomes with Master Splicing Factors

Jangi, M., & Sharp, P. A. (2014) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 141