Akiyama, Haruhiko

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 4,514

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., et al. (2006) · Biochemical and Biophysical Research Communications

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 2,732

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development

Osteoarthritis Treatment and MechanismsDevelopmental Biology and Gene Regulation

Cited by 1,721

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

Mackenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., et al. (2010) · Acta Neuropathologica

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 1,012

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 940

Prion-like spreading of pathological α-synuclein in brain

Masuda-Suzukake, M., Nonaka, T., Hosokawa, M., Oikawa, T., Arai, T., Akiyama, H., Mann, D. M. A., & Hasegawa, M. (2013) · Brain

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 867

Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Hasegawa, M., Arai, T., Nonaka, T., Kametani, F., Yoshida, M., Hashizume, Y., Beach, T. G., Buratti, E., Baralle, F., Morita, M., et al. (2008) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 777

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 697

Microglia in degenerative neurological disease

McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 596

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 481

Brain microglia constitutively express β-2 integrins

Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 430

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

Yanger, K., Knigin, D., Zong, Y., Maggs, L., Gu, G., Akiyama, H., Pikarsky, E., & Stanger, B. Z. (2014) · Cell Stem Cell

Liver physiology and pathologyMesenchymal stem cell research

Cited by 426

Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters

Complement system in diseasesAlzheimer's disease research and treatments

Cited by 383

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

Arai, T., Mackenzie, I. R. A., Hasegawa, M., Nonoka, T., Niizato, K., Tsuchiya, K., Iritani, S., Onaya, M., & Akiyama, H. (2009) · Acta Neuropathologica

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 345

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

Itagaki, S., McGeer, P. L., & Akiyama, H. (1988) · Neuroscience Letters

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 271

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa

Akiyama, H., Chaboissier, M.-C., Behringer, R. R., Rowitch, D. H., Schedl, A., Epstein, J. A., & de Crombrugghe, B. (2004) · Proceedings of the National Academy of Sciences

Congenital heart defects researchDevelopmental Biology and Gene Regulation

Cited by 265

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

Taniguchi-Watanabe, S., Arai, T., Kametani, F., Nonaka, T., Masuda-Suzukake, M., Tarutani, A., Murayama, S., Saito, Y., Arima, K., Yoshida, M., et al. (2016) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 200

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

Tooyama, I., Kimura, H., Akiyama, H., & McGeer, P. L. (1990) · Brain Research

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 180

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 137

Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles

Ikeda, K., Akiyama, H., Kondo, H., Haga, C., Tanno, E., Tokuda, T., & Ikeda, S. (1995) · Acta Neuropathologica

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 119

Changes in density of calcium‐binding‐protein‐immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder

Sakai, T., Oshima, A., Nozaki, Y., Ida, I., Haga, C., Akiyama, H., Nakazato, Y., & Mikuni, M. (2008) · Neuropathology

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 118

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation

Tarutani, A., Suzuki, G., Shimozawa, A., Nonaka, T., Akiyama, H., Hisanaga, S.-I., & Hasegawa, M. (2016) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 118

Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration

Tanimizu, N., Nishikawa, Y., Ichinohe, N., Akiyama, H., & Mitaka, T. (2014) · Journal of Biological Chemistry

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 105

Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62

Arai, T., Nonaka, T., Hasegawa, M., Akiyama, H., Yoshida, M., Hashizume, Y., Tsuchiya, K., Oda, T., & Ikeda, K. (2003) · Neuroscience Letters

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 92