Bellen, Hugo J.

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

Liu, L., Zhang, K., Sandoval, H., Yamamoto, S., Jaiswal, M., Sanz, E., Li, Z., Hui, J., Graham, B. H., Quintana, A., et al. (2015) · Cell

Autophagy in Disease and TherapyMitochondrial Function and Pathology

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Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

Verstreken, P., Ly, C. V., Venken, K. J. T., Koh, T.-W., Zhou, Y., & Bellen, H. J. (2005) · Neuron

Cellular transport and secretionMitochondrial Function and Pathology

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

Liu, L., MacKenzie, K. R., Putluri, N., Maletić-Savatić, M., & Bellen, H. J. (2017) · Cell Metabolism

Lipid metabolism and biosynthesisAlzheimer's disease research and treatments

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Synaptic Vesicle Size and Number Are Regulated by a Clathrin Adaptor Protein Required for Endocytosis

Zhang, B., Koh, Y. H., Beckstead, R. B., Budnik, V., Ganetzky, B., & Bellen, H. J. (1998) · Neuron

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 434

Huntingtin functions as a scaffold for selective macroautophagy

Rui, Y.-N., Xu, Z., Patel, B., Chen, Z., Chen, D., Tito, A., David, G., Sun, Y., Stimming, E. F., Bellen, H. J., et al. (2015) · Nature Cell Biology

Autophagy in Disease and TherapyGenetic Neurodegenerative Diseases

Cited by 423

Position effects on eukaryotic gene expression

Wilson, C., Bellen, H. J., & Gehring, W. J. (1990) · Annual Review of Cell Biology

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 379

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease

Splinter, K., Adams, D. R., Bacino, C. A., Bellen, H. J., Bernstein, J. A., Cheatle-Jarvela, A. M., Eng, C. M., Esteves, C., Gahl, W. A., Hamid, R., et al. (2018) · New England Journal of Medicine

Genomics and Rare DiseasesMetabolism and Genetic Disorders

Cited by 359

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N. A., Pan, H., Haltiwanger, R. S., & Bellen, H. J. (2008) · Cell

Developmental Biology and Gene RegulationGlycosylation and Glycoproteins Research

Cited by 306

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Zhai, R. G., Zhang, F., Hiesinger, P. R., Cao, Y., Haueter, C. M., & Bellen, H. J. (2008) · Nature

Genetic Neurodegenerative DiseasesHeat shock proteins research

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Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer's Disease-Associated Genes

Moulton, M. J., Barish, S., Ralhan, I., Chang, J., Goodman, L. D., Harland, J. G., Marcogliese, P. C., Johansson, J. O., Ioannou, M. S., & Bellen, H. J. (2021) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsLipid metabolism and biosynthesis

Cited by 180

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity

Zhai, R. G., Cao, Y., Hiesinger, P. R., Zhou, Y., Mehta, S. Q., Schulze, K. L., Verstreken, P., & Bellen, H. J. (2006) · PLoS Biology

Nerve injury and regenerationNeurobiology and Insect Physiology Research

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Loss-or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms

Chung, H.-L., Wangler, M. F., Marcogliese, P. C., Jo, J., Ravenscroft, T. A., Zuo, Z., Duraine, L., Sadeghzadeh, S., Li-Kroeger, D., Schmidt, R. E., et al. (2020) · Neuron

Hereditary Neurological DisordersMetabolism and Genetic Disorders

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Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components

Mehta, S. Q., Hiesinger, P. R., Beronja, S., Zhai, R. G., Schulze, K. L., Verstreken, P., Cao, Y., Zhou, Y., Tepass, U., Crair, M. C., et al. (2005) · Neuron

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 136

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification

Şentürk, M., Lin, G., Zuo, Z., Mao, D., Watson, E., Mikos, A. G., & Bellen, H. J. (2019) · Nature Cell Biology

Autophagy in Disease and TherapyAmyotrophic Lateral Sclerosis Research

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Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages

Wong, C.-O., Gregory, S., Hu, H., Chao, Y., Sepúlveda, V. E., He, Y., Li-Kroeger, D., Goldman, W. E., Bellen, H. J., & Venkatachalam, K. (2017) · Cell Host & Microbe

Immune Response and InflammationInvertebrate Immune Response Mechanisms

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Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives

Giagtzoglou, N., Ly, C. V., & Bellen, H. J. (2009) · Cold Spring Harbor Perspectives in Biology

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

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NMNATs, evolutionarily conserved neuronal maintenance factors

Ali, Y. O., Li-Kroeger, D., Bellen, H. J., Zhai, R. G., & Lu, H.-C. (2013) · Trends in Neurosciences

Nerve injury and regenerationNuclear Receptors and Signaling

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Neuron-subtype-specific expression, interaction affinities, and specificity determinants of DIP/Dpr cell recognition proteins

Cosmanescu, F., Katsamba, P. S., Sergeeva, A. P., Ahlsen, G., Patel, S. D., Brewer, J. J., Tan, L., Xu, S., Xiao, Q., Nagarkar-Jaiswal, S., et al. (2018) · Neuron

Axon Guidance and Neuronal SignalingNeurobiology and Insect Physiology Research

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Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation

Chung, H.-L., Ye, Q., Park, Y.-J., Zuo, Z., Mok, J.-W., Kanca, O., Tattikota, S. G., Lu, S., Perrimon, N., Lee, H. K., et al. (2023) · Cell Metabolism

Sphingolipid Metabolism and SignalingMultiple Sclerosis Research Studies

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The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit

Zhang, K., Li, Z., Jaiswal, M., Bayat, V., Xiong, B., Sandoval, H., Charng, W.-L., David, G., Haueter, C., Yamamoto, S., et al. (2013) · Journal of Cell Biology

Mitochondrial Function and PathologyHeat shock proteins research

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PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

Kozlova, A., Zhang, S., Sudwarts, A., Zhang, H., Smirnou, S., Byeon, S. K., Thapa, C., Sun, X., Stephenson, K., Zhao, X., et al. (2025) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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AI-MARRVEL — A Knowledge-Driven AI System for Diagnosing Mendelian Disorders

Mao, D., Liu, C., Wang, L., AI-Ouran, R., Deisseroth, C., Pasupuleti, S., Kim, S. Y., Li, L., Rosenfeld, J. A., Meng, L., et al. (2024) · NEJM AI

Genomics and Rare DiseasesArtificial Intelligence in Healthcare and Education

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cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

Ojelade, S. A., Lee, T. V., Giagtzoglou, N., Yu, L., Ugur, B., Li, Y., Duraine, L., Zuo, Z., Petyuk, V., De Jager, P. L., et al. (2019) · Cell Reports

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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