Wurst, Wolfgang

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 4,293

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 1,470

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Chu, V. T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K., & Kühn, R. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 1,210

High-throughput discovery of novel developmental phenotypes

The International Mouse Phenotyping Consortium, Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., et al. (2016) · Nature

Genomics and Rare DiseasesZebrafish Biomedical Research Applications

Cited by 1,196

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 919

Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 827

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell

Genetics and Neurodevelopmental DisordersAnimal Vocal Communication and Behavior

Cited by 605

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology

Genetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals

Cited by 507

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, M., Jakupoglu, C., Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., Beck, H., Hatzopoulos, A. K., Just, U., Sinowatz, F., et al. (2004) · Molecular and Cellular Biology

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 485

Inducible gene deletion in astroglia and radial glia—A valuable tool for functional and lineage analysis

Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 398

Rapamycin extends murine lifespan but has limited effects on aging

Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 374

Development of an intein-mediated split-Cas9 system for gene therapy

Truong, D.-J. J., Kühner, K., Kühn, R., Werfel, S., Engelhardt, S., Wurst, W., & Ortiz, O. (2015) · Nucleic Acids Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 371

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

Mazaheri, F., Snaidero, N., Kleinberger, G., Madore, C., Daria, A., Werner, G., Krasemann, S., Capell, A., Trümbach, D., Wurst, W., et al. (2017) · The EMBO Reports

Neuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathways

Cited by 351

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

Beckervordersandforth, R., Ebert, B., Schäffner, I., Moss, J., Fiebig, C., Shin, J., Moore, D. L., Ghosh, L., Trinchero, M. F., Stockburger, C., et al. (2017) · Neuron

Neurogenesis and neuroplasticity mechanismsMitochondrial Function and Pathology

Cited by 303

Prevalence of sexual dimorphism in mammalian phenotypic traits

Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., et al. (2017) · Nature Communications

Sex and Gender in HealthcareGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 257

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Xiang, X., Piers, T. M., Wefers, B., Zhu, K., Mallach, A., Brunner, B., Kleinberger, G., Song, W., Colonna, M., Herms, J., et al. (2018) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 170

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus

Chen, Y., Bender, R. A., Brunson, K. L., Pomper, J. K., Grigoriadis, D. E., Wurst, W., & Baram, T. Z. (2004) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Cited by 166

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T. W., Koeglsperger, T., Wurst, W., Behrends, C., & Höglinger, G. U. (2018) · Cell Death & Disease

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 161

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Schäffner, I., Minakaki, G., Khan, M. A., Balta, E.-A., Schlötzer-Schrehardt, U., Schwarz, T. J., Beckervordersandforth, R., Winner, B., Webb, A. E., DePinho, R. A., et al. (2018) · Neuron

FOXO transcription factor regulationNeurogenesis and neuroplasticity mechanisms

Cited by 145

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 142

Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer

Brodski, C., Weisenhorn, D. M. V., Signore, M., Sillaber, I., Oesterheld, M., Broccoli, V., Acampora, D., Simeone, A., & Wurst, W. (2003) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 131

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

Di Salvio, M., Di Giovannantonio, L. G., Acampora, D., Prosperi, R., Omodei, D., Prakash, N., Wurst, W., & Simeone, A. (2010) · Nature Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 118

MicroRNA-9 controls dendritic development by targeting REST

Giusti, S. A., Vogl, A. M., Brockmann, M. M., Vercelli, C. A., Rein, M. L., Trümbach, D., Wurst, W., Cazalla, D., Stein, V., Deussing, J. M., et al. (2014) · eLife

MicroRNA in disease regulationNeuroscience and Neuropharmacology Research

Cited by 113

Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice

Rolyan, H., Scheffold, A., Heinrich, A., Begus-Nahrmann, Y., Langkopf, B. H., Hölter, S. M., Vogt-Weisenhorn, D. M., Liss, B., Wurst, W., Lie, D. C., et al. (2011) · Brain

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 106