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Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus

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Chen, Yuncai, Bender, Roland A., Brunson, Kristen L., Pomper, Jörn K., Grigoriadis, Dimitri E., Wurst, Wolfgang, Baram, Tallie Z.·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0403975101PMC PMC524840
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Abstract

The interplay of environmental and genetic factors in the developmental organization of the hippocampus has not been fully elucidated. The neuropeptide corticotropin-releasing factor (CRF) is released from hippocampal interneurons by environmental signals, including stress, to increase synaptic efficacy. In the early postnatal hippocampus, we have previously characterized a transient population of CRF-expressing Cajal-Retzius-like cells. Here we queried whether this stress-activated neuromodulator influences connectivity in the developing hippocampal network. Using mice deficient in the principal hippocampal CRF receptor [CRF(1)(-/-)] and organotypic cultures grown in the presence of synthetic CRF, or CRF receptor antagonists, we found robust effects of CRF on dendritic differentiation in hippocampal neurons. In CRF(1)(-/-) mice, the dendritic trees of hippocampal principal cells were exuberant, an effect that was induced in normal hippocampi in vitro by the presence of CRF(1) antagonists. In both cases, total dendritic length and dendritic branching were significantly increased. In contrast, exogenous synthetic CRF blunted the dendritic growth in hippocampal organotypic cultures. Taken together, these findings suggest that endogenous CRF, if released excessively by previous early postnatal stress, might influence neuronal connectivity and thus function of the immature hippocampus.

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Authors
Chen, Y., Bender, R. A., Brunson, K. L., Pomper, J. K., Grigoriadis, D. E., Wurst, W., & Baram, T. Z.
Affiliations
  • University of California, Irvine (US)
  • Departments of Anatomy/Neurobiology and Pediatrics, University of California, Irvine, CA 92697-4475; Neurocrine Biosciences, Incorporated, San Diego, CA 92121-1102; and Max Planck Institute of Psychiatry, Gesellschaft für Strahlenforschung Research Center, Munich 80804, Germany
Corresponding author
Baram, Tallie Z.
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-10-20
Volume
101
Issue
44
Pages
15782-15787
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0403975101
PMC
PMC524840
OpenAlex
W2071132017
Cited by
166
References
69
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 12
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Site cant be reached (submittedVersion, cc-by)
Funders
National Institute of Neurological Disorders and Stroke (NS 28912, R01NS028912, NS 39307, R01NS039307)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
corticotropin-releasing factor, CRF1 receptor, dendritic differentiation, hippocampus development, postpartum stress, dendritic branching, dendritic length, organotypic hippocampal slice cultures, neuronal connectivity
MeSH terms
CRF Receptor, Type 1, Animals, Animals, Newborn, Corticotropin-Releasing Hormone, Dendrites, Hippocampus, Organ Culture Techniques, Pyrimidines, Rats, Sprague-Dawley, Pyramidal Cells, Receptors, Corticotropin-Releasing Hormone, Mice, Knockout, Mice, Rats

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