Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
Open accessAbstract
Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of hippocampal neurons from quiescent neural stem cells (NSCs). The identity of stage-specific metabolic programs and their impact on adult neurogenesis are largely unknown. We show that the adult hippocampal neurogenic lineage is critically dependent on the mitochondrial electron transport chain and oxidative phosphorylation machinery at the stage of the fast proliferating intermediate progenitor cell. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurogenesis defects. Together with the finding of age-associated alterations in mitochondrial function and morphology in NSCs, these data link mitochondrial complex function to efficient lineage progression of adult NSCs and identify mitochondrial function as a potential target to ameliorate neurogenesis-defects in the aging hippocampus.
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Knockout of Tfam mimics ageing in NSCs, whereas enhancement of mitochondrial function by piracetam boosts neurogenesis in aged mice.
“Knockout of Tfam (a central transcription factor for mitochondria) mimics ageing in NSCs, whereas enhancement of mitochondrial function by piracetam boosts neurogenesis in aged mice125.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [125]
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Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,718 · see citing works
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139 · see citing works
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594 · see citing works
Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
Self-citationMitochondrial Membrane Potential Probes and the Proton Gradient: A Practical Usage Guide
Perry, S. W., Norman, J. P., Barbieri, J., Brown, E. B., & Gelbard, H. A. (2011) · BioTechniques · doi:10.2144/000113610 · Cited by 1,196 · see citing works
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
Sullivan, L. B., Gui, D. Y., Hosios, A. M., Bush, L. N., Freinkman, E., & Vander Heiden, M. G. (2015) · Cell · doi:10.1016/j.cell.2015.07.017 · Cited by 1,173 · see citing works
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150 · see citing works
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037 · see citing works
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · see citing works
Reconstruct : a free editor for serial section microscopy
Fiala, J. C. (2005) · Journal of Microscopy · doi:10.1111/j.1365-2818.2005.01466.x · Cited by 884 · see citing works
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791 · see citing works
Self-citationSingle-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis
Shin, J., Berg, D. A., Zhu, Y., Shin, J. Y., Song, J., Bonaguidi, M. A., Enikolopov, G., Nauen, D. W., Christian, K. M., Ming, G.-L., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.013 · Cited by 784 · see citing works
Self-citationLugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704 · see citing works
WikiPathways: Pathway Editing for the People
Pico, A. R., Kelder, T., van Iersel, M. P., Hanspers, K., Conklin, B. R., & Evelo, C. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060184 · Cited by 701 · see citing works
Khacho, M., Clark, A., Svoboda, D. S., Azzi, J., MacLaurin, J. G., Meghaizel, C., Sesaki, H., Lagace, D. C., Germain, M., Harper, M., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.015 · Cited by 672 · see citing works
Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671 · cited 9× · see citing works
“…reports indicated that highly proliferating embryonic neural stem and progenitor cells are glycolytic and that high oxPhos activity is associated with termination of proliferation and neuronal differentiation (Agathocleous et al., 2012; Homem et al., 2014; Khacho et al., 2016; Zheng et al., 2016).”
BackgroundResultInfluentialMetabolic Plasticity in Stem Cell Homeostasis and Differentiation
Folmes, C. D. L., Dzeja, P. P., Nelson, T. J., & Terzic, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.002 · Cited by 664 · see citing works
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635 · see citing works
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Ekstrand, M. I., Terzioglu, M., Galter, D., Zhu, S., Hofstetter, C., Lindqvist, E., Thams, S., Bergstrand, A., Hansson, F. S., Trifunovic, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605208103 · Cited by 605 · cited 2× · see citing works
“A number of studies have found that Tfam conditional knockout mice almost invariably develop a phenotype only after weeks to months following disruption of the Tfam locus, most likely owing to the long half-life of Tfam transcripts, Tfam protein, and Tfam targets (Ekstrand et al., 2007; Silva et al., 2000; Sörensen et…”
BackgroundMetabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
Knobloch, M., Braun, S., Zurkirchen, L., Schoultz, C., Zamboni, N., Araúzo-Bravo, M., Kovacs, W. J., Karalay, Ö., Suter, U., Machado, R. A. C., et al. (2012) · Nature · doi:10.1038/nature11689 · Cited by 503 · see citing works
Self-citationβ2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Smith, L. K., He, Y., Park, J.-S., Bieri, G., Snethlage, C. E., Lin, K., Gontier, G., Wabl, R., Plambeck, K. E., Udeochu, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3898 · Cited by 500 · see citing works
Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.016 · Cited by 480 · see citing works
Self-citationHall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451 · see citing works
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential
Lie, D. C., Dziewczapolski, G., Willhoite, A. R., Kaspar, B. K., Shults, C. W., & Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06639.2002 · Cited by 449 · see citing works
Self-citationWang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J. C., Kahn, C. R., Clayton, D. A., Barsh, G. S., et al. (1999) · Nature Genetics · doi:10.1038/5089 · Cited by 435 · see citing works
Silva, J. P., Köhler, M., Graff, C., Oldfors, A., Magnuson, M. A., Berggren, P.-O., & Larsson, N.-G. (2000) · Nature Genetics · doi:10.1038/81649 · Cited by 433 · see citing works
Mitochondria and Neuroplasticity
Cheng, A., Hou, Y., & Mattson, M. P. (2010) · ASN NEURO · doi:10.1042/an20100019 · Cited by 433 · see citing works
Energy-Efficient Action Potentials in Hippocampal Mossy Fibers
Alle, H., Roth, A., & Geiger, J. R. P. (2009) · Science · doi:10.1126/science.1174331 · Cited by 429 · see citing works
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398 · see citing works
Self-citationFunctions and Dysfunctions of Adult Hippocampal Neurogenesis
Christian, K. M., Song, H., & Ming, G. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014134 · Cited by 395 · see citing works
Self-citationYamaguchi, M., Saito, H., Suzuki, M., & Mori, K. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00037 · Cited by 393 · see citing works
Nakamura, T., Colbert, M. C., & Robbins, J. M. (2006) · Circulation Research · doi:10.1161/01.res.0000227505.19472.69 · Cited by 343 · see citing works
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis
Steiner, B., Klempin, F., Wang, L., Kott, M., Kettenmann, H., & Kempermann, G. (2006) · Glia · doi:10.1002/glia.20407 · Cited by 342 · see citing works
Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline
Seib, D. R., Corsini, N. S., Ellwanger, K., Plaas, C., Mateos, Á., Pitzer, C., Niehrs, C., Celikel, T., & Martín-Villalba, A. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.010 · Cited by 291 · see citing works
Energy metabolism in adult neural stem cell fate
Rafalski, V. A., & Brunet, A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.007 · Cited by 280 · see citing works
Homem, C. C. F., Steinmann, V., Burkard, T. R., Jais, A., Esterbauer, H., & Knoblich, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.06.024 · Cited by 243 · see citing works
Ahlqvist, K. J., Hämäläinen, R. H., Yatsuga, S., Uutela, M., Terzioglu, M., Götz, A., Forsström, S., Salvén, P., Angers‐Loustau, A., Kopra, O., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.012 · Cited by 240 · see citing works
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescencePreprint
Martynoga, B., Mateo, J. L., Zhou, B., Andersen, J., Achimastou, A., Urbán, N., van den Berg, D. L. C., Georgopoulou, D., Hadjur, S., Wittbrodt, J., et al. (2013) · Genes & Development · doi:10.1101/gad.216804.113 · Cited by 204 · see citing works
Metabolic differentiation in the embryonic retina
Agathocleous, M., Love, N. K., Randlett, O., Harris, J. J., Liu, J., Murray, A. J., & Harris, W. A. (2012) · Nature Cell Biology · doi:10.1038/ncb2531 · Cited by 182 · see citing works
Mitochondria and cancer: is there a morphological connection?
Alirol, E., & Martinou, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209600 · Cited by 169 · see citing works
Sörensen, L., Ekstrand, M., Silva, J., Lindqvist, E., Xu, B., Rustin, P., Olson, L., & Larsson, N.-G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08082.2001 · Cited by 167 · see citing works
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells
Yeo, H., Lyssiotis, C. A., Zhang, Y., Ying, H., Asara, J. M., Cantley, L. C., & Paik, J.-H. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.186 · Cited by 145 · see citing works
INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
Hamberger, A., & Hydén, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.16.3.521 · Cited by 144 · see citing works
Hodge, R. D., Nelson, B. R., Kahoud, R. J., Yang, R., Mussar, K. E., Reiner, S. L., & Hevner, R. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0532-12.2012 · Cited by 144 · see citing works
Stoll, E. A., Makin, R., Sweet, I. R., Trevelyan, A. J., Miwa, S., Horner, P. J., & Turnbull, D. M. (2015) · Stem Cells · doi:10.1002/stem.2042 · Cited by 139 · see citing works
Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo
Tashiro, A., Zhao, C., & Gage, F. H. (2006) · Nature Protocols · doi:10.1038/nprot.2006.473 · Cited by 136 · see citing works
Spatiotemporal Changes to the Subventricular Zone Stem Cell Pool through Aging
Shook, B. A., Manz, D. H., Peters, J. J., Kang, S., & Conover, J. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5987-11.2012 · Cited by 136 · see citing works
Stem Cell Review Series: Role of neurogenesis in age‐related memory disorders
Drapeau, E., & Abrous, D. N. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00369.x · Cited by 136 · see citing works
Clinical Efficacy of Piracetam in Cognitive Impairment: A Meta-Analysis
Waegemans, T., Wilsher, C. R., Danniau, A., Ferris, S. H., Kurz, A., & Winblad, B. G. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000057700 · Cited by 132 · see citing works
Mitochondria Modify Exercise-Induced Development of Stem Cell-Derived Neurons in the Adult Brain
Steib, K., Schäffner, I., Jagasia, R., Ebert, B., & Lie, D. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4972-13.2014 · Cited by 128 · see citing works
Self-citationInteraction between Neurogenesis and Hippocampal Memory System: New VistasPreprint
Abrous, D. N., & Wojtowicz, J. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018952 · Cited by 121 · see citing works
Moss, J., Gebara, E., Bushong, E. A., Sánchez-Pascual, I., O’Laoi, R., M’Ghari, I. E., Kocher-Braissant, J., Ellisman, M. H., & Toni, N. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514652113 · Cited by 120 · see citing works
Self-citationPiracetam improves mitochondrial dysfunction following oxidative stress
Keil, U., Scherping, I., Hauptmann, S., et al. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706459 · Cited by 98 · see citing works
Neural Stem Cell of the Hippocampus
Rolando, C., & Taylor, V. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00007-x · Cited by 91 · see citing works
Hou, Y., Ouyang, X., Wan, R., Cheng, H., Mattson, M. P., & Cheng, A. (2012) · Stem Cells · doi:10.1002/stem.1213 · Cited by 90 · see citing works
Translational Control of Mitochondrial Energy Production Mediates Neuron Morphogenesis
Oruganty-Das, A., Ng, T., Udagawa, T., Goh, E. L. K., & Richter, J. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.002 · Cited by 79 · see citing works
Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism
Stoll, E. A., Cheung, W., Mikheev, A. M., Sweet, I. R., Bielas, J. H., Zhang, J., Rostomily, R., & Horner, P. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252171 · Cited by 74 · see citing works
Leuner, K. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00044 · Cited by 70 · see citing works
A KINETIC STUDY OF THE NEURON-GLIA RELATIONSHIP
Hydén, H., & Lange, P. W. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.13.2.233 · Cited by 68 · see citing works
Kurz, C., Ungerer, I., Lipka, U., Kirr, S., Schütt, T., Eckert, A., Leuner, K., & Müller, W. E. G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00656.x · Cited by 55 · see citing works
Forsberg, K., Wuttke, A., Quadrato, G., Chumakov, P. M., Wizenmann, A., & Giovanni, S. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1056-13.2013 · Cited by 47 · see citing works
Systemic administration of catalpol prevents d-galactose induced mitochondrial dysfunction in mice
Zhang, X., Liu, W., Niu, X., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.02.054 · Cited by 37 · see citing works
Costa, R. A. P. E., Fernandes, M. P., de Souza-Pinto, N. C., & Vercesi, A. E. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.001 · Cited by 35 · see citing works
Improvement of mitochondrial function and dynamics by the metabolic enhancer piracetam
Stockburger, C., Kurz, C., Koch, K. A., Eckert, S. H., Leuner, K., & Müller, W. E. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130054 · Cited by 29 · see citing works
Self-citationMetabolic regulation of adult stem cell-derived neurons
Beckervordersandforth, R., Häberle, B. M., & Lie, D. C. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1351-5 · Cited by 6 · see citing works
Self-citationMetabolic control of adult neural stem cell behavior
Knobloch, M., & Jessberger, S. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1349-z · Cited by 2 · see citing works
Self-citationNolte (2001) · doi:10.1002/1098-1136(20010101)33:1
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- Authors
- Beckervordersandforth, R., Ebert, B., Schäffner, I., Moss, J., Fiebig, C., Shin, J., Moore, D. L., Ghosh, L., Trinchero, M. F., Stockburger, C., Friedland, K., Steib, K., von Wittgenstein, J., Keiner, S., Redecker, C., Hölter, S. M., Xiang, W., Wurst, W., Jagasia, R., Schinder, A. F., Ming, G.-L., Toni, N., Jessberger, S., Song, H., & Lie, D. C.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Lausanne (CH)
- Johns Hopkins University (US)
- University of Zurich (CH)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Helmholtz Munich (DE)
- Jena University Hospital (DE)
- F. Hoffmann-La Roche AG (CH)
- Corresponding author
- Beckervordersandforth, Ruth
- Lie, D. Chichung
- ORCID
- Beckervordersandforth, Ruth
- Schäffner, Iris
- Fiebig, Christian
- Shin, Jaehoon
- Moore, Darcie L.
- Trinchero, Mariela F.
- Friedland, Kristina
- Keiner, Silke
- Redecker, Christoph
- Hölter, Sabine M.
- Xiang, Wei
- Wurst, Wolfgang
- Jagasia, Ravi
- Schinder, Alejandro F.
- Ming, Guo-li
- Toni, Nicolas
- Jessberger, Sebastian
- Song, Hongjun
- Lie, D. Chichung
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 93
- Issue
- 3
- Pages
- 560-573.e6
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5300896
- OpenAlex
- W2579202888
- Cited by
- 303
- References
- 74
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 30 · 2023: 30 · 2022: 37 · 2021: 36 · 2020: 43 · 2019: 36 · 2018: 27 · 2017: 21 · 2013: 1
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-03-22)
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- Site cant be reached (submittedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- SERVAL (Université de Lausanne) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schering foundation
- German Research Foundation (BE 5136/1-1, LI 858/6-3, 9-1, INST 410/45-1 FUGG)
- Bavarian Research Network “ForIPS,”
- Helmholtz Alliance for Mental Health in an Ageing Society
- University Hospital Erlangen (E12, E16, E21, E11)
- NIH (R37NS047344, P01 NS097206, R35NS097370, R01MH105128)
- Swiss National Science Foundation (SNSF 31003A-156943, PPOOA-119026/1)
- Deutsche Forschungsgemeinschaft (DFG GRK2162/1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial metabolism, adult hippocampal neurogenesis, neural stem cells, intermediate progenitor cells, lineage progression, aging, mitochondrial electron transport chain, oxidative phosphorylation, TFAM, mitochondrial morphology
- MeSH terms
- Aging, Animals, Cells, Cultured, DNA-Binding Proteins, High Mobility Group Proteins, Hippocampus, Mice, Transgenic, Mitochondria, Neurons, Oxidative Phosphorylation, Mice, Knockout, Cell Lineage, Electron Transport Chain Complex Proteins, Cell Proliferation, Mice, Adult Stem Cells, Neurogenesis, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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