MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
Open accessAbstract
Subsets of rodent neurons are reported to express major histocompatibility complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidence from immunolabel, RNA expression and mass spectrometry analysis of postmortem samples that human catecholaminergic substantia nigra and locus coeruleus neurons express MHC-I, and that this molecule is inducible in human stem cell-derived dopamine (DA) neurons. Catecholamine murine cultured neurons are more responsive to induction of MHC-I by gamma-interferon than other neuronal populations. Neuronal MHC-I is also induced by factors released from microglia activated by neuromelanin or alpha-synuclein, or high cytosolic DA and/or oxidative stress. DA neurons internalize foreign ovalbumin and display antigen derived from this protein by MHC-I, which triggers DA neuronal death in the presence of appropriate cytotoxic T cells. Thus, neuronal MHC-I can trigger antigenic response, and catecholamine neurons may be particularly susceptible to T-cell-mediated cytotoxic attack.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glutamate induces •NO in neurons and is released during ischemia-reperfusion such as stroke or sleep apnea, which are accompanied by ONOO-.
“The endogenous excitotoxin glutamate also induces •NO in neurons (216) and is released during ischemia-reperfusion such as in stroke or sleep apnea, which are accompanied by ONOO– (34).”
From Chemiexcitation: Mammalian Photochemistry in the Dark<sup>†</sup> (2023) · cites this paper as [216]
The Results section on oxidative stress discusses dopamine-derived oxidation and neuronal MHC-I expression, not glutamate release during ischemia-reperfusion or ONOO− in stroke or sleep apnea. Searches for those terms and for nitric oxide found no passage addressing the point attributed to this source; the glutamate-induced •NO clause carries a different citation. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
Self-citationT cell receptor antagonist peptides induce positive selection.
Hogquist, K., Jameson, S., Heath, W., Howard, J. L., Bevan, M., & Carbone, F. (1994) · Cell · doi:10.1016/0092-8674(94)90169-4 · Cited by 3,252 · see citing works
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
Kriks, S., Shim, J., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo‐Reid, L., Auyeung, G., Antonacci, C. L., Buch, A., et al. (2011) · Nature · doi:10.1038/nature10648 · Cited by 1,912 · see citing works
Self-citationBrochard, V., Combadière, B., Prigent, A., Laouar, Y., Perrin, A., Beray-Berthat, V., Bonduelle, O., Alvarez-Fischer, D., Callebert, J., Launay, J.-M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36470 · Cited by 1,172 · see citing works
Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct
Conway, K. A., Rochet, J.-C., Bieganski, R. M., & Lansbury, P. T. (2001) · Science · doi:10.1126/science.1063522 · Cited by 1,127 · see citing works
Microglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works
PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease
Zheng, B., Liao, Z., Locascio, J. J., Lesniak, K. A., Roderick, S. S., Watt, M. L., Eklund, A. C., Zhang‐James, Y., Kim, P. D., Hauser, M. A., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001059 · Cited by 854 · see citing works
Self-citationFunctional requirement for class I MHC in CNS development and plasticity
Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., & Shatz, C. J. (2000) · Science · doi:10.1126/science.290.5499.2155 · Cited by 828 · see citing works
Nomenclature for Factors of the HLA System, 2004
Marsh, S. G. E., Albert, E. D., Bodmer, W. F., Bontrop, R. E., Dupont, B., Erlich, H. A., Geraghty, D. E., Hansen, J. A., Hurley, C. K., Mach, B., et al. (2005) · Human Immunology · doi:10.1016/j.humimm.2005.02.002 · Cited by 818 · see citing works
Inducible expression of H–2 and Ia antigens on brain cells
Wong, G. H., Bartlett, P. F., Clark‐Lewis, I., Battye, F. L., & Schrader, J. W. (1984) · Nature · doi:10.1038/310688a0 · Cited by 653 · see citing works
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
Martínez‐Vicente, M., Tallóczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J. R., Mosharov, E. V., Hodara, R., Fredenburg, R. A., Wu, D.-C., Follenzi, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32806 · Cited by 633 · see citing works
Self-citationRegulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity
Corriveau, R. A., Huh, G. S., & Shatz, C. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80562-0 · Cited by 548 · see citing works
Mosharov, E. V., Larsen, K. E., Kanter, E., Phillips, K. A., Wilson, K., Schmitz, Y., Krantz, D. E., Kobayashi, K., Edwards, R. H., & Sulzer, D. L. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.033 · Cited by 530 · see citing works
Self-citationGeneralized Lévy walks and the role of chemokines in migration of effector CD8+ T cells
Harris, T. H., Banigan, E. J., Christian, D. A., Konradt, C., Wojno, E. D. T., Norose, K., Wilson, E. H., John, B., Weninger, W., Luster, A. D., et al. (2012) · Nature · doi:10.1038/nature11098 · Cited by 512 · see citing works
Nomenclature for factors of the HLA system, 2004
Marsh, S. G. E., Albert, E. D., Bodmer, W. F., Bontrop, R. E., Dupont, B., Erlich, H. A., Geraghty, D. E., Hansen, J. A., Hurley, C. K., Mach, B., et al. (2005) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2005.00509.x · Cited by 511 · see citing works
Nomenclature for factors of the HLA system, 2004
Marsh, S. G. E., Albert, E. D., Bodmer, W. F., Bontrop, R. E., Dupont, B., Erlich, H. A., Geraghty, D. E., Hansen, J. A., Hurley, C. K., Mach, B., et al. (2005) · Tissue Antigens · doi:10.1111/j.1399-0039.2005.00379.x · Cited by 498 · see citing works
Zecca, L., Stroppolo, A., Gatti, A., Tampellini, D., Toscani, M., Gallorini, M., Giaveri, G., Arosio, P., Santambrogio, P., Fariello, R. G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403495101 · Cited by 495 · see citing works
Self-citationSulzer, D. L., Bogulavsky, J. J., Larsen, K. E., Behr, G. G., Karatekin, E., Kleinman, M. H., Turro, N. J., Krantz, D. E., Edwards, R. H., Greene, L. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11869 · Cited by 460 · see citing works
Self-citationInduction of MHC Class I Genes in Neurons
Neumann, H., Cavalié, A., Jenne, D. E., & Wekerle, H. (1995) · Science · doi:10.1126/science.7624779 · Cited by 449 · see citing works
Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis
Bien, C. G., Bauer, J., Deckwerth, T. L., Wiendl, H., Deckert, M., Wiestler, O. D., Schramm, J., Elger, C. E., & Lassmann, H. (2002) · Annals of Neurology · doi:10.1002/ana.10100 · Cited by 364 · see citing works
Šimunović, F., Yi, M., Wang, Y., Macey, L., Brown, L. T., Krichevsky, A. M., Andersen, S. L., Stephens, R. M., Benes, F. M., & Sonntag, K. (2008) · Brain · doi:10.1093/brain/awn323 · Cited by 350 · see citing works
Regulation of CNS synapses by neuronal MHC class I
Goddard, C. A., Butts, D. A., & Shatz, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702023104 · Cited by 322 · see citing works
A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy
de Oliveira, A. L. R., Thams, S., Lidman, O., Piehl, F., Hökfelt, T. G. M., Kärre, K., Lindå, H., & Cullheim, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408154101 · Cited by 288 · see citing works
Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos, H., & Lee, V. M.-Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412621200 · Cited by 273 · see citing works
Neurodegeneration and neuroprotection in Parkinson disease
Fahn, S., & Sulzer, D. L. (2004) · Neurotherapeutics · doi:10.1602/neurorx.1.1.139 · Cited by 266 · see citing works
Self-citationZhang, W., Phillips, K., Wielgus, A. R., Liu, J., Albertini, A., Zucca, F. A., Faust, R., Qian, S. Y., Miller, D. S., Chignell, C. F., et al. (2011) · Neurotoxicity Research · doi:10.1007/s12640-009-9140-z · Cited by 257 · see citing works
Self-citationp53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain
Mogi, M., Kondo, T., Mizuno, Y., & Nagatsu, T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.12.003 · Cited by 242 · see citing works
Zecca, L., Bellei, C., Costi, P., Albertini, A., Monzani, E., Casella, L., Gallorini, M., Bergamaschi, L., Moscatelli, A., Turro, N. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808768105 · Cited by 240 · see citing works
Calcium homeostasis, selective vulnerability and Parkinson's disease
Chan, C. S., Gertler, T. S., & Surmeier, D. J. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.006 · Cited by 239 · see citing works
Farkas, E., de Jong, G. I., de Vos, R. A. I., Steur, E. N. H. J., & Luiten, P. G. M. (2000) · Acta Neuropathologica · doi:10.1007/s004010000195 · Cited by 218 · see citing works
Dopamine Oxidation and Autophagy
Muñoz, P., Huenchuguala, S., Paris, I., & Segura-Aguilar, J. (2012) · Parkinson's Disease · doi:10.1155/2012/920953 · Cited by 214 · see citing works
MHCI negatively regulates synapse density during the establishment of cortical connections
Glynn, M. W., Elmer, B. M., Garay, P. A., Liu, X.-B., Needleman, L. A., El-Sabeawy, F., & McAllister, A. K. (2011) · Nature Neuroscience · doi:10.1038/nn.2764 · Cited by 198 · see citing works
Rothenberg, B. E., & Voland, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1529 · Cited by 194 · see citing works
Tooyama, I., Kimura, H., Akiyama, H., & McGeer, P. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)91496-4 · Cited by 180 · see citing works
Béraud, D., Hathaway, H. A., Trecki, J., Chasovskikh, S., Johnson, D. A., Johnson, J. A., Federoff, H. J., Shimoji, M., Mhyre, T. R., & Maguire‐Zeiss, K. A. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9401-0 · Cited by 175 · see citing works
Transcriptional regulation of antigen presentation
van den Elsen, P. J., Holling, T. M., Kuipers, H. F., & van der Stoep, N. (2003) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.11.015 · Cited by 172 · see citing works
Zhang, W., Dallas, S., Zhang, D., Guo, J., Pang, H., Wilson, B. C., Miller, D. S., Chen, B., Zhang, W., McGeer, P. L., et al. (2007) · Glia · doi:10.1002/glia.20532 · Cited by 161 · see citing works
Zhao, Y., Wang, F., Fan, Y., Ping, G.-F., Yang, J., & Wu, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.052 · Cited by 153 · see citing works
Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis
Tallóczy, Z., Martínez, J., Joset, D., Ray, Y., Gácser, A., Toussi, S., Mizushima, N., Nosanchuk, J., Goldstein, H., Loike, J., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040028 · Cited by 147 · see citing works
Self-citationToxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants
Pardo, B., Mena, M. A., Casarejos, M. J., Paı́no, C. L., & de Yébenes, J. G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00341-m · Cited by 134 · see citing works
Production of interferon-γ by microglia
Kawanokuchi, J., Mizuno, T., Takeuchi, H., Kato, H., Wang, J.-J., Mitsuma, N., & Suzumura, A. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070763 · Cited by 133 · see citing works
Imamura, K., Hishikawa, N., Ono, K., Suzuki, H., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0919-y · Cited by 131 · see citing works
Budhu, S., Loike, J. D., Pandolfi, A., Han, S. J., Catalano, G., Constantinescu, A., Clynes, R., & Silverstein, S. C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091279 · Cited by 125 · see citing works
Self-citationNeedleman, L. A., Liu, X.-B., El-Sabeawy, F., Jones, E. G., & McAllister, A. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006087107 · Cited by 105 · see citing works
Antigen Loading of MHC Class I Molecules in the Endocytic Tract
Kleijmeer, M. J., Escola, J.-M., UytdeHaag, F. G. C. M., Jakobson, E., Griffith, J. M., Osterhaus, A. D. M. E., Stoorvogel, W., Melief, C. J. M., Rabouille, C., & Geuze, H. J. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.020207.x · Cited by 105 · see citing works
Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection
Chevalier, G., Suberbielle, E., Monnet, C., Duplan-Eche, V., Martin‐Blondel, G., Farrugia, F., Masson, G. L., Liblau, R., & Gonzalez‐Dunia, D. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002393 · Cited by 97 · see citing works
Mangano, E. N., Litteljohn, D., So, R., Nelson, E., Peters, S., Bethune, C., Bobyn, J., & Hayley, S. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.016 · Cited by 96 · see citing works
Meuth, S. G., Herrmann, A. M., Simon, O. J., Siffrin, V., Melzer, N., Bittner, S., Meuth, P., Langer, H. F., Hallermann, S., Boldakowa, N., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4339-09.2009 · Cited by 94 · see citing works
Lindå, H., Hammarberg, H., Cullheim, S., Levinovitz, A., Khademi, M., & Olsson, T. P. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6768 · Cited by 90 · see citing works
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification
Chakrabarty, P., Ceballos‐Diaz, C., Lin, W.-L., Beccard, A., Jansen‐West, K. R., McFarland, N. R., Janus, C., Dickson, D. W., Das, P., & Golde, T. E. (2011) · Nature Neuroscience · doi:10.1038/nn.2829 · Cited by 81 · see citing works
Amphisomal Route of MHC Class I Cross-Presentation in Bacteria-Infected Dendritic Cells
Fiegl, D., Kägebein, D., Liebler–Tenorio, E., Weißer, T., Sens, M., Gutjahr, M., & Knittler, M. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202741 · Cited by 74 · see citing works
Alternative pathways for MHC class I presentation: a new function for autophagy
Chemali, M., Radtke, K., Desjardins, M., & English, L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0660-3 · Cited by 70 · see citing works
Neuronal vulnerability in Parkinson's disease
Double, K. L. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70018-9 · Cited by 59 · see citing works
Teoh, C., & Davies, K. J. A. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.001 · Cited by 56 · see citing works
Prabowo, A. S., Iyer, A. M., Anink, J. J., Spliet, W. G. M., van Rijen, P. C., & Aronica, E. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-12 · Cited by 54 · see citing works
Human neuromelanin an endogenous microglial activator for dopaminergic neuron death
Zhang, W. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e591 · Cited by 53 · see citing works
Nelson, P. A., Sage, J. R., Wood, S. C., Davenport, C. M., Anagnostaras, S. G., & Boulanger, L. M. (2013) · Learning & Memory · doi:10.1101/lm.031351.113 · Cited by 49 · see citing works
Both Human and Mouse Cells Expressing H-2Kb and Ovalbumin Process the Same Peptide, SIINFEKL
Falk, K., Rötzschke, O., Faath, S., Goth, S. R., Graef, I. A., Shastri, N., & Rammensee, H. (1993) · Cellular Immunology · doi:10.1006/cimm.1993.1212 · Cited by 27 · see citing works
Zhang, A., Yu, H., He, Y., Shen, Y., Pan, N., Liu, J., Fu, B., Miao, F., & Zhang, J. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.001 · Cited by 26 · see citing works
Liu, J., Shen, Y., Li, M., Shi, Q., Zhang, A., Miao, F., Liu, J., Wu, X., He, Y., & Zhang, J. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0920-0 · Cited by 24 · see citing works
Letellier, M., Willson, M. L., Gautheron, V., Mariani, J., & Lohof, A. M. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20639 · Cited by 24 · see citing works
Abraham, S., Nagaraj, A. S., Basak, S., & Manjunath, R. (2010) · Journal of Virology · doi:10.1128/jvi.02250-09 · Cited by 22 · see citing works
The Expression Patterns of MHC Class I Molecules in the Developmental Human Visual System
Zhang, A., Yu, H., Shen, Y., Liu, J., He, Y., Shi, Q., Fu, B., Miao, F., & Zhang, J. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0916-9 · Cited by 19 · see citing works
Foix, C., & Nicolesco, J. (1925) · Masson eBooks · Cited by 15 · see citing works
Parkinson's Disease: A Role for the Immune System
German, D. C., Eagar, T. N., & Sonsalla, P. K. (2013) · Current Molecular Pharmacology · doi:10.2174/1874467211205030003 · Cited by 15 · see citing works
Interferon-induced parkinsonism in a patient with chronic hepatitis C
de Almeida, C. M. O., Galvão, M. D. L. D. S., Ferreira, P. L. D. C., & Braga, W. S. M. (2009) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2009000400031 · Cited by 9 · see citing works
Early T cell development can be traced in rat fetal liver
Alonso-C., L. M., Múñoz, J. J., & Zapata, A. G. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200012)30:12 · Cited by 6 · see citing works
Sulzer, D., Trudeau, L., & Rayport, S. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374028-1.00037-3 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [31]Sulzer D Trudeau LE Rayport S Nass R Parkinson’s Disease: Molecular and Therapeutic Insights from Model Systems 491 504 Academic Press 2008
Cited by
Sorted by citations
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415 · see citing works
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., et al. (2017) · Nature · doi:10.1038/nature22815 · Cited by 866 · see citing works
Self-citationInflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779 · see citing works
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.012 · Cited by 659 · see citing works
Self-citationParkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation
Matheoud, D., Sugiura, A., Bellemare-Pelletier, A., Laplante, A., Rondeau, C., Chemali, M., Fazel, A., Bergeron, J. J., Trudeau, L.-E., Burelle, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.039 · Cited by 582 · see citing works
Intestinal infection triggers Parkinson's disease-like symptoms in Pink1(-/-) mice
Matheoud, D., Cannon, T., Voisin, A., Penttinen, A.-M., Ramet, L., Fahmy, A. M., Ducrot, C., Laplante, A., Bourque, M.-J., Zhu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1405-y · Cited by 496 · see citing works
Ge, P., Dawson, V. L., & Dawson, T. M. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00367-7 · Cited by 514 · see citing works
Melanins and melanogenesis: from pigment cells to human health and technological applications
d’Ischia, M., Wakamatsu, K., Cicoira, F., Mauro, E. D., García-Borrón, J. C., Commo, S., Galván, I., Ghanem, G., Kenzo, K., Meredith, P., et al. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12393 · Cited by 491 · see citing works
Self-citationParkinson disease and the immune system - Associations, mechanisms and therapeutics
Tan, E.-K., Chao, Y.-X., West, A., Chan, L.-L., Poewe, W., & Jankovic, J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0344-4 · Cited by 457 · see citing works
New insights into the complex role of mitochondria in Parkinson’s disease
Grünewald, A., Kumar, K. R., & Sue, C. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.09.003 · Cited by 362 · see citing works
Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease
Sommer, A., Marxreiter, F., Krach, F., Fadler, T., Grosch, J., Maroni, M., Graef, D., Eberhardt, E., Riemenschneider, M. J., Yeo, G. W., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.06.015 · Cited by 332 · see citing works
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease
Williams, G. P., Schonhoff, A. M., Jurkuvenaite, A., Corbin-Stein, N. J., Standaert, D. G., & Harms, A. S. (2021) · Brain · doi:10.1093/brain/awab103 · Cited by 308 · see citing works
Microglial phenotypes in Parkinson’s disease and animal models of the disease
Joers, V., Tansey, M. G., Mulas, G., & Carta, A. R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.006 · Cited by 285 · see citing works
Sulzer, D. L., Cassidy, C., Horga, G., Kang, U. J., Fahn, S., Casella, L., Pezzoli, G., Langley, J. A., Hu, X. P., Zucca, F. A., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0047-3 · Cited by 277 · see citing works
Self-citationQin, H., Buckley, J. A., Li, X., Liu, Y., Fox, T. H., Meares, G. P., Yu, H., Yan, Z., Harms, A. S., Li, Y., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4658-15.2016 · Cited by 275 · see citing works
Periphery and brain, innate and adaptive immunity in Parkinson’s disease
Harms, A. S., Ferreira, S. A., & Romero‐Ramos, M. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02268-5 · Cited by 279 · see citing works
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease
Galiano-Landeira, J., Torra, A., Vila, M., & Bové, J. (2020) · Brain · doi:10.1093/brain/awaa269 · Cited by 267 · see citing works
Biomarker of Neuroinflammation in Parkinson’s Disease
Liu, T.-W., Chen, C., & Chang, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084148 · Cited by 264 · see citing works
Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease
Allen Reish, H. E., & Standaert, D. G. (2015) · Journal of Parkinson’s Disease · doi:10.3233/jpd-140491 · Cited by 244 · see citing works
Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain
Cassidy, C., Zucca, F. A., Girgis, R. R., Baker, S. C., Weinstein, J. J., Sharp, M. E., Bellei, C., Valmadre, A., Vanegas‐Arroyave, N., Kegeles, L. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807983116 · Cited by 247 · see citing works
Self-citationCD4 + T cells contribute to neurodegeneration in Lewy body dementia
Gate, D., Tapp, E., Leventhal, O., Shahid, M., Nonninger, T. J., Yang, A. C., Strempfl, K., Unger, M. S., Fehlmann, T., Oh, H. S., et al. (2021) · Science · doi:10.1126/science.abf7266 · Cited by 209 · see citing works
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Duffy, M. F., Collier, T. J., Patterson, J. R., Kemp, C. J., Luk, K. C., Tansey, M. G., Paumier, K. L., Kanaan, N. M., Fischer, D. L., Polinski, N. K., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1171-z · Cited by 197 · see citing works
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
Zeng, X., Geng, W.-S., Jia, J., Chen, L., & Zhang, P.-P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00109 · Cited by 194 · see citing works
Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
Troncoso-Escudero, P., Parra, A., Nassif, M., & Vidal, R. L. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00860 · Cited by 191 · see citing works
Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities
Araújo, B., Caridade-Silva, R., Soares-Guedes, C., Martins‐Macedo, J., Gomes, E. D., Monteiro, S., & Teixeira, F. G. (2022) · Cells · doi:10.3390/cells11182908 · Cited by 198 · see citing works
Duarte, L. F., Farías, M. A., Álvarez, D. M., Bueno, S. M., Riedel, C. A., & González, P. A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00046 · Cited by 189 · see citing works
α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
Harms, A. S., Delic, V., Thome, A. D., Bryant, N., Liu, Z., Chandra, S., Jurkuvenaite, A., & West, A. B. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0494-9 · Cited by 181 · see citing works
Immune system responses in Parkinson's disease: Early and dynamic
Tansey, M. G., & Romero‐Ramos, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14290 · Cited by 183 · see citing works
Inflammation, Infectious Triggers, and Parkinson's Disease
Caggiu, E., Arru, G., Hosseiniporgham, S., Niegowska, M., Sechi, G., Zarbo, I. R., & Sechi, L. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00122 · Cited by 178 · see citing works
Recent Advances in Biomarkers for Parkinson’s Disease
He, R., Yan, X., Guo, J., Xu, Q., Tang, B., & Sun, Q. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00305 · Cited by 178 · see citing works
Copas, A. N. M., McComish, S. F., Fletcher, J. M., & Caldwell, M. A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.666737 · Cited by 175 · see citing works
Fang, H., Knezevic, B., Burnham, K. L., & Knight, J. C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0384-y · Cited by 173 · see citing works
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells
Garretti, F., Agalliu, D., Arlehamn, C. S. L., Sette, A., & Sulzer, D. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00303 · Cited by 162 · see citing works
Self-citationThe cell biology of Parkinson’s disease
Panicker, N., Ge, P., Dawson, V. L., & Dawson, T. M. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202012095 · Cited by 164 · see citing works
Zucca, F. A., Vanna, R., Cupaioli, F. A., Bellei, C., Palma, A. D., Silvestre, D. D., Mauri, P., Grassi, S., Prinetti, A., Casella, L., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0050-8 · Cited by 152 · see citing works
Self-citationNeuromelanin, aging, and neuronal vulnerability in Parkinson's disease
Vila, M. (2019) · Movement Disorders · doi:10.1002/mds.27776 · Cited by 147 · see citing works
The immune system in Parkinson's disease: what we know so far
Roodveldt, C., Bernardino, L. I., Çakmak, Ö. Ö., Dragić, M., Fladmark, K. E., Ertan, S., Aktaş, B., Pita, C., Ciglar, L., Garraux, G., et al. (2024) · Brain · doi:10.1093/brain/awae177 · Cited by 148 · see citing works
Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase
Nagatsu, T., Nakashima, A., Watanabe, H., Ito, S., & Wakamatsu, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084176 · Cited by 142 · see citing works
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
Kozina, E. A., Sadasivan, S., Jiao, Y., Dou, Y., Ma, Z., Tan, H., Kodali, K., Shaw, T. I., Peng, J., & Smeyne, R. J. (2018) · Brain · doi:10.1093/brain/awy077 · Cited by 137 · see citing works
Panagiotakopoulou, V., Ivanyuk, D., Cicco, S. D., Haq, W., Arsić, A., Yu, C., Messelodi, D., Oldrati, M., Schöndorf, D. C., Maria Jose Perez, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18755-4 · Cited by 130 · see citing works
Kline, E. M., Houser, M. C., Herrick, M. K., Seibler, P., Klein, C., West, A. B., & Tansey, M. G. (2020) · Movement Disorders · doi:10.1002/mds.28411 · Cited by 131 · see citing works
Autophagy and Parkinson’s Disease
Lu, J., Wu, M., & Yue, Z. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-15-4272-5_2 · Cited by 131 · see citing works
Cebrián, C., Loike, J. D., & Sulzer, D. L. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00114 · Cited by 119 · see citing works
Self-citationNew Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
Zhang, G., Xia, Y. F., Wan, F. J., Ma, K., Guo, X., Kou, L., Yin, S., Han, C., Liu, L., Huang, J., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00370 · Cited by 115 · see citing works
Innate and adaptive immune responses in Parkinson's disease
Schonhoff, A. M., Williams, G. P., Wallen, Z. D., Standaert, D. G., & Harms, A. S. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.10.006 · Cited by 115 · see citing works
Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS
Natale, G., Limanaqi, F., Busceti, C. L., Mastroiacovo, F., Nicoletti, F., Puglisi‐Allegra, S., & Fornai, F. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.639140 · Cited by 112 · see citing works
Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease
Yan, Z., Yang, W., Wei, H., Dean, M. N., Standaert, D. G., Cutter, G., Benveniste, E. N., & Qin, H. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001036 · Cited by 110 · see citing works
Cancer cell-intrinsic mechanisms driving acquired immune tolerance
Ghorani, E., Swanton, C., & Quezada, S. A. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.004 · Cited by 108 · see citing works
Neurodegeneration: From cellular concepts to clinical applications
Katsnelson, A., Strooper, B. D., & Zoghbi, H. Y. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2074 · Cited by 106 · see citing works
α-Synuclein pathology as a target in neurodegenerative diseases
Park, H.-J., Kam, T., Dawson, V. L., & Dawson, T. M. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01043-w · Cited by 112 · see citing works
Iron homeostasis imbalance and ferroptosis in brain diseases
Long, H., Zhu, W., Wei, L., & Zhao, J. (2023) · MedComm · doi:10.1002/mco2.298 · Cited by 101 · see citing works
Benskey, M. J., Sellnow, R. C., Sandoval, I. M., Sortwell, C. E., Lipton, J. W., & Manfredsson, F. P. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00036 · Cited by 102 · see citing works
Immune responses in the Parkinson's disease brain
Weiss, F. C., Labrador‐Garrido, A., Dzamko, N. L., & Halliday, G. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105700 · Cited by 97 · see citing works
Wise, R. M., Wagener, A., Fietzek, U. M., Klopstock, T., Mosharov, E. V., Zucca, F. A., Sulzer, D. L., Zecca, L., & Burbulla, L. F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105920 · Cited by 95 · see citing works
Self-citationLuppi, M. P., Azcorra, M., Caronia, G., Poulin, J.-F., Gaertner, Z. A., Gatica, S., Moreno-Ramos, O. A., Nouri, N., Dubois, M., Ma, Y. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109975 · Cited by 100 · see citing works
Videira, P. A., & Castro‐Caldas, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00381 · Cited by 93 · see citing works
Williams, G. P., Schonhoff, A. M., Jurkuvenaite, A., Thome, A. D., Standaert, D. G., & Harms, A. S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1286-2 · Cited by 90 · see citing works
Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies
Limanaqi, F., Biagioni, F., Gambardella, S., Familiari, P., Frati, A., & Fornai, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21083028 · Cited by 93 · see citing works
The role of natural killer cells in Parkinson’s disease
Earls, R. H., & Lee, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00505-7 · Cited by 92 · see citing works
Cui, P., Lu, W., Wang, J., Wang, F., Zhang, X., Hou, X., Xu, F., Liang, Y., Chai, G., & Hao, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02705-0 · Cited by 89 · see citing works
Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity
Tafti, M., Lammers, G. J., Dauvilliers, Y. A., Overeem, S., Mayer, G., Nowak, J., Pfister, C., Dubois, V., Eliaou, J., Eberhard, H., et al. (2016) · SLEEP · doi:10.5665/sleep.5532 · Cited by 84 · see citing works
Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
Sonninen, T.-M., Goldsteins, G., Laham-Karam, N., Koıstınaho, J., & Lehtonen, Š. (2020) · Cells · doi:10.3390/cells9102183 · Cited by 84 · see citing works
Wengler, K., He, X., Abi‐Dargham, A., & Horga, G. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116457 · Cited by 79 · see citing works
The role of T cells in the pathogenesis of Parkinson’s disease
Chen, Z., Chen, S., & Liu, J. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.08.002 · Cited by 78 · see citing works
The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
Sommer, A., Winner, B., & Prots, I. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0222-8 · Cited by 80 · see citing works
Limanaqi, F., Biagioni, F., Mastroiacovo, F., Polzella, M., Lazzeri, G., & Fornai, F. (2020) · Antioxidants · doi:10.3390/antiox9101022 · Cited by 79 · see citing works
Wakamatsu, K., Tabuchi, K., Ojika, M., Zucca, F. A., Zecca, L., & Ito, S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13237 · Cited by 76 · see citing works
Self-citationPicca, A., Guerra, F., Calvani, R., Bucci, C., Monaco, M. R. L., Bentivoglio, A. R., Landi, F., Bernabei, R., & Marzetti, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102373 · Cited by 78 · see citing works
Presynaptic effects of levodopa and their possible role in dyskinesia
Mosharov, E. V., Borgkvist, A., & Sulzer, D. L. (2014) · Movement Disorders · doi:10.1002/mds.26103 · Cited by 77 · see citing works
Self-citationZucca, F. A., Capucciati, A., Bellei, C., Sarna, M., Sarna, T., Monzani, E., Casella, L., & Zecca, L. (2023) · IUBMB Life · doi:10.1002/iub.2654 · Cited by 69 · see citing works
Self-citationAlpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson’s Disease
Saramowicz, K., Siwecka, N., Galita, G., Kucharska-Lusina, A., Rozpędek‐Kamińska, W., & Majsterek, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010360 · Cited by 76 · see citing works
A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome
Limanaqi, F., Biagioni, F., Gaglione, A., Busceti, C. L., & Fornai, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00628 · Cited by 69 · see citing works
Melanin and neuromelanin binding of drugs and chemicals: toxicological implications
Karlsson, O., & Lindquist, N. G. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1757-0 · Cited by 69 · see citing works
Luna, E., & Luk, K. C. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.10.023 · Cited by 65 · see citing works
Biesemeier, A., Eibl, O., Eswara, S., Audinot, J., Wirtz, T., Pezzoli, G., Zucca, F. A., Zecca, L., & Schraermeyer, U. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13648 · Cited by 67 · see citing works
Self-citationBido, S., Nannoni, M., Muggeo, S., Gambarè, D., Ruffini, G., Bellini, E. N., Passeri, L., Iaia, S., Luoni, M., Provinciali, M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adm8563 · Cited by 67 · see citing works
The Neuromelanin Paradox and Its Dual Role in Oxidative Stress and Neurodegeneration
Moreno-García, A., Kun, A., Calero, M., & Calero, O. (2021) · Antioxidants · doi:10.3390/antiox10010124 · Cited by 64 · see citing works
Cebrián, C., Loike, J. D., & Sulzer, D. (2014) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2014_356 · Cited by 65 · see citing works
Self-citationNeuroinflammation in Parkinson’s Disease: Triggers, Mechanisms, and Immunotherapies
Wang, T., Shi, C., Luo, H., Zheng, H., Fan, L., Tang, M., Su, Y., Yang, J., Mao, C., & Xu, Y. (2021) · The Neuroscientist · doi:10.1177/1073858421991066 · Cited by 66 · see citing works
Midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions
Abellanas, M. A., Zamarbide, M., Basurco, L., Luquin, E., García‐Granero, M., Clavero, P., Martín‐Úriz, P. S., Vilas‐Zornoza, A., Mengual, E., Hervás‐Stubbs, S., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1628-8 · Cited by 64 · see citing works
T Lymphocytes in Parkinson’s Disease
Contaldi, E., Magistrelli, L., & Comi, C. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223152 · Cited by 62 · see citing works
Majbour, N. K., Aasly, J. O., Hustad, E., Thomas, M. A., Vaikath, N. N., Elkum, N. B., van de Berg, W. D. J., Tokuda, T., Mollenhauer, B., Berendse, H. W., et al. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00192-4 · Cited by 62 · see citing works
The systemic immune response in Parkinson’s disease: focus on the peripheral immune component
Lauritsen, J., & Romero‐Ramos, M. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.005 · Cited by 64 · see citing works
Roles for the adaptive immune system in Parkinson’s and Alzheimer’s diseases
Arlehamn, C. S. L., Garretti, F., Sulzer, D. L., & Sette, A. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.07.004 · Cited by 61 · see citing works
Self-citationInflammation as common link to progressive neurological diseases
Dias-Carvalho, A., Sá, S. I., Carvalho, F., Fernandes, E., & Costa, V. M. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03628-8 · Cited by 60 · see citing works
Progress of immunotherapy of anti-α-synuclein in Parkinson's disease.
Wang, Z.-P., Gao, G., Duan, C., & Yang, H. (2019) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2019.108843 · Cited by 48 · see citing works
Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons
Salvioni, A., Belloy, M., Lebourg, A., Bassot, E., Cantaloube-Ferrieu, V., Vasseur, V., Blanié, S., Liblau, R., Suberbielle, E., Robey, E. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.051 · Cited by 59 · see citing works
β1-Integrin– and KV1.3 channel–dependent signaling stimulates glutamate release from Th17 cells
Birkner, K., Wasser, B., Ruck, T., Thalman, C., Luchtman, D. W., Pape, K., Schmaul, S., Bitar, L., Krämer‐Albers, E., Stroh, A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126381 · Cited by 59 · see citing works
Sobue, A., Ito, N., Nagai, T., Wei, S., Hada, K., Nakajima, A., Murakami, Y., Mouri, A., Yamamoto, Y., Nabeshima, T., et al. (2018) · Glia · doi:10.1002/glia.23299 · Cited by 58 · see citing works
The key role of T cells in Parkinson's disease pathogenesis and therapy
Baird, J. K., BOURDETTE, D. N., Meshul, C. K., & Quinn, J. F. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2018.10.029 · Cited by 58 · see citing works
Nagatsu, T., Nakashima, A., Watanabe, H., Ito, S., Wakamatsu, K., Zucca, F. A., Zecca, L., Youdim, M. B. H., Wulf, M., Riederer, P. F., et al. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02617-6 · Cited by 56 · see citing works
Self-citationAbnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson’s disease
Sun, C., Zhao, Z., Yu, W., Mo, M., Song, C., Si, Y., & Liu, Y. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.10.105 · Cited by 55 · see citing works
Vagaská, B., New, S. E. P., Álvarez-González, C., D’Acquisto, F., Gomez, S. G., Bulstrode, N., Madrigal, J. A., & Ferretti, P. (2016) · Scientific Reports · doi:10.1038/srep24251 · Cited by 53 · see citing works
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease
Caggiu, E., Paulus, K. S., Galleri, G., Arru, G., Manetti, R., Sechi, G., & Sechi, L. A. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.06.004 · Cited by 52 · see citing works
Association of inflammatory factors and aging in Parkinson's disease
Jin, H., Gu, H., Mao, C., Chen, J., & Liu, C. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135259 · Cited by 52 · see citing works
The biomarkers of immune dysregulation and inflammation response in Parkinson disease
Chen, L., Mo, M., Li, G., Cen, L., Wei, L., Xiao, Y., Chen, X., Li, S., Yang, X., Qu, S., et al. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0063-3 · Cited by 51 · see citing works
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
Jiang, T., Li, G., Xu, J., Gao, S., & Xu, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02047 · Cited by 51 · see citing works
Cassidy, C., Carpenter, K. M., Konova, A. B., Cheung, V., Grassetti, A., Zecca, L., Abi‐Dargham, A., Martinez, D., & Horga, G. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010090 · Cited by 48 · see citing works
Self-citationBenitez, J. A., Cheng, S., Kee, N., Cao, M., Wang, M., Deng, Q., & Hedlund, E. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.699562 · Cited by 47 · see citing works
CD8+ T cells in brain injury and neurodegeneration
Zhang, Z., Duan, Z., & Cui, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1281763 · Cited by 47 · see citing works
- Authors
- Cebrián, C., Zucca, F. A., Mauri, P., Steinbeck, J. A., Studer, L., Scherzer, C. R., Kanter, E., Budhu, S., Mandelbaum, J., Vonsattel, J. P., Zecca, L., Loike, J. D., & Sulzer, D.
- Affiliations
- Columbia University Irving Medical Center (US)
- Institute of Biomedical Technologies (IT)
- Memorial Sloan Kettering Cancer Center (US)
- Brigham and Women's Hospital (US)
- Takeda Oncology (United States) (US)
- Corresponding author
- Sulzer, David
- ORCID
- Venue
- Nature Communications
- Published
- 2014-04-16
- Volume
- 5
- Issue
- 1
- Pages
- 3633-3633
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4024461
- OpenAlex
- W2138900023
- Cited by
- 338
- References
- 72
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 31 · 2023: 36 · 2022: 38 · 2021: 28 · 2020: 34 · 2019: 29 · 2018: 35 · 2017: 19 · 2016: 19 · 2015: 15 · 2014: 7
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- U.S. Department of Defense
- Parkinson's Disease Foundation
- McLean Hospital
- JPB Foundation
- New York State Stem Cell Science
- Deutsche Forschungsgemeinschaft
- Ministero dell’Istruzione, dell’Università e della Ricerca (PB.P05)
- Fundación Caja Madrid
- National Institutes of Health
- National Institute on Drug Abuse (P01DA010154, R01DA007418)
- National Institute of Neurological Disorders and Stroke (R01NS064155, P50NS038370, U01NS082080, U01NS082157)
- National Center for Research Resources (S10RR026895)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- catecholaminergic neurons, substantia nigra, locus coeruleus, dopaminergic neurons, Parkinson's disease, microglial activation, alpha-synuclein, neuromelanin, interferon-gamma, oxidative stress, ovalbumin antigen, cytotoxic T lymphocytes, stem cell-derived neurons
- MeSH terms
- Aged, Aged, 80 and over, Animals, Cell Survival, Dopamine, Female, Genes, MHC Class I, Humans, Interferon-gamma, Locus Coeruleus, Male, Melanins, Middle Aged, Parkinson Disease, RNA, Messenger, Substantia Nigra, T-Lymphocytes, Cytotoxic, Histocompatibility Antigens Class I, Microglia, Oxidative Stress, Gene Expression Profiling, Mice, alpha-Synuclein, Dopaminergic Neurons, Adrenergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
