Karikó, Katalin

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 2,728

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery

RNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

Cited by 2,474

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 1,977

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy

RNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

Cited by 1,930

mRNA is an endogenous ligand for toll-like receptor 3

Karikó, K., Ni, H., Capodici, J., Lamphier, M., & Weissman, D. (2004) · Journal of Biological Chemistry

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,062

BNT162b2 induces SARS-CoV-2-neutralising antibodies and T cells in humans

Sahin, U., Muik, A., Vogler, I., Derhovanessian, E., Kranz, L. M., Vormehr, M., Quandt, J., Bidmon, N., Ulges, A., Baum, A., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 914

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Karikó, K., Muramatsu, H., Ludwig, J., & Weissman, D. (2011) · Nucleic Acids Research

RNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

Cited by 898

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Pardi, N., Hogan, M. J., Pelc, R. S., Muramatsu, H., Andersen, H., DeMaso, C. R., Dowd, K. A., Sutherland, L. L., Scearce, R. M., Parks, R., et al. (2017) · Nature

Mosquito-borne diseases and controlRNA Interference and Gene Delivery

Cited by 884

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Alameh, M.-G., Tombácz, I., Bettini, E., Lederer, K., Ndeupen, S., Sittplangkoon, C., Wilmore, J. R., Gaudette, B. T., Soliman, O. Y., Pine, M., et al. (2021) · Immunity

Immunotherapy and Immune ResponsesImmune responses and vaccinations

Cited by 775

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Anderson, B. R., Muramatsu, H., Nallagatla, S. R., Bevilacqua, P. C., Sansing, L. H., Weissman, D., & Karikó, K. (2010) · Nucleic Acids Research

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 682

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 601

A facile method for the removal of dsRNA contaminant from in vitro-transcribed mRNA

Baiersdörfer, M., Boros, G., Muramatsu, H., Mahiny, A., Vlatkovic, I., Sahin, U., & Karikó, K. (2019) · Molecular Therapy — Nucleic Acids

RNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

Cited by 569

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Pardi, N., Hogan, M. J., Naradikian, M. S., Parkhouse, K., Cain, D. W., Jones, L., Moody, M. A., Verkerke, H. P., Myles, A., Willis, E., et al. (2018) · Journal of Experimental Medicine

Immunotherapy and Immune ResponsesRNA Interference and Gene Delivery

Cited by 530

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Krienke, C., Kolb, L., Diken, E., Streuber, M., Kirchhoff, S., Bukur, T., Akilli-Öztürk, Ö., Kranz, L. M., Berger, H., Petschenka, J., et al. (2021) · Science

Multiple Sclerosis Research StudiesImmunotherapy and Immune Responses

Cited by 520

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Pardi, N., Secreto, A. J., Shan, X., Debonera, F., Glover, J., Yi, Y., Muramatsu, H., Ni, H., Mui, B. L., Tam, Y. K., et al. (2017) · Nature Communications

RNA Interference and Gene DeliveryMonoclonal and Polyclonal Antibodies Research

Cited by 352

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine

Muramatsu, H., Lam, K., Bajusz, C., Laczkó, D., Karikó, K., Schreiner, P., Martin, A., Lutwyche, P., Heyes, J., & Pardi, N. (2022) · Molecular Therapy

RNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 Research

Cited by 331

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Stadler, C. R., Bähr-Mahmud, H., Celik, L., Hebich, B., Roth, A. S., Roth, R. P., Karikó, K., Türeci, Ö., & Sahin, U. (2017) · Nature Medicine

Monoclonal and Polyclonal Antibodies ResearchRNA Interference and Gene Delivery

Cited by 290

Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin

Karikó, K., Muramatsu, H., Keller, J. M., & Weissman, D. (2012) · Molecular Therapy

RNA Interference and Gene DeliveryErythropoietin and Anemia Treatment

Cited by 282

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Pardi, N., Parkhouse, K., Kirkpatrick, E., McMahon, M., Zost, S. J., Mui, B. L., Tam, Y. K., Karikó, K., Barbosa, C. J., Madden, T. D., et al. (2018) · Nature Communications

Influenza Virus Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 281

HPLC purification of in vitro transcribed long RNA

Weissman, D., Pardi, N., Muramatsu, H., & Karikó, K. (2013) · Methods in molecular biology

RNA and protein synthesis mechanismsRNA Interference and Gene Delivery

Cited by 180

Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques

Pardi, N., LaBranche, C. C., Ferrari, G., Cain, D. W., Tombácz, I., Parks, R. J., Muramatsu, H., Mui, B. L., Tam, Y. K., Karikó, K., et al. (2019) · Molecular Therapy - Nucleic Acids

HIV Research and TreatmentSARS-CoV-2 and COVID-19 Research

Cited by 103

Overexpression of urokinase receptor in mammalian cells following administration of the in vitro transcribed encoding mRNA

Karikó, K., Kuo, A., & Barnathan, E. S. (1999) · Gene Therapy

RNA Interference and Gene DeliveryRNA Research and Splicing

Cited by 89

Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune Responses

Cited by 31

In vivo protein expression from mRNA delivered into adult rat brain

Karikó, K., Keller, J. M., Harris, V. A., Langer, D. J., & Welsh, F. A. (2001) · Journal of Neuroscience Methods

RNA Interference and Gene DeliveryMolecular Biology Techniques and Applications

Cited by 24