Piomelli, Daniele

Endocannabinoid signaling mediates oxytocin-driven social reward

Wei, D., Lee, D., Cox, C. D., Karsten, C. A., Peñagarikano, O., Geschwind, D. H., Gall, C. M., & Piomelli, D. (2015) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchNeuroendocrine regulation and behavior

Cited by 218

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 183

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3′-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

Russo, R., LoVerme, J., La Rana, G., Compton, T. R., Parrott, J., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Calignano, A., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 182

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

Fu, J., Bottegoni, G., Sasso, O., Bertorelli, R., Rocchia, W., Masetti, M., Guijarro, A., Lodola, A., Armirotti, A., Garau, G., et al. (2012) · Nature Neuroscience

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 175

Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer’s Disease

Simoni, E., Daniele, S., Bottegoni, G., Pizzirani, D., Trincavelli, M. L., Goldoni, L., Tarozzo, G., Reggiani, A., Martini, C., Piomelli, D., et al. (2012) · Journal of Medicinal Chemistry

Cholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloids

Cited by 163

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer’s disease

Astarita, G., Jung, K.-M., Vasilevko, V., DiPatrizio, N. V., Martin, S. K., Cribbs, D. H., Head, E., Cotman, C. W., & Piomelli, D. (2011) · PLoS ONE

Alzheimer's disease research and treatmentsFatty Acid Research and Health

Cited by 146

Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity

Wang, H., Astarita, G., Taussig, M. D., Bharadwaj, K. G., DiPatrizio, N. V., Nave, K.-A., Piomelli, D., Goldberg, I. J., & Eckel, R. H. (2011) · Cell Metabolism

Regulation of Appetite and ObesityLipid metabolism and disorders

Cited by 139

Fat-induced satiety factor oleoylethanolamide enhances memory consolidation

Campolongo, P., Roozendaal, B., Trezza, V., Cuomo, V., Astarita, G., Fu, J., McGaugh, J. L., & Piomelli, D. (2009) · Proceedings of the National Academy of Sciences

Memory and Neural MechanismsRegulation of Appetite and Obesity

Cited by 133

More surprises lying ahead. The endocannabinoids keep us guessing

Piomelli, D. (2014) · Neuropharmacology

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 128

Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment

Wei, D., Dinh, D., Lee, D., Li, D., Anguren, A., Moreno-Sanz, G., Gall, C. M., & Piomelli, D. (2016) · Cannabis and Cannabinoid Research

Cannabis and Cannabinoid ResearchAutism Spectrum Disorder Research

Cited by 122

Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]

La Rana, G., Russo, R., Campolongo, P., Bortolato, M., Mangieri, R. A., Cuomo, V., Iacono, A., Raso, G. M., Meli, R., Piomelli, D., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 97

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

Sasso, O., Bertorelli, R., Bandiera, T., Scarpelli, R., Colombano, G., Armirotti, A., Moreno-Sanz, G., Reggiani, A., & Piomelli, D. (2012) · Pharmacological Research

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 96

Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats

Sciolino, N. R., Bortolato, M., Eisenstein, S. A., Fu, J., Oveisi, F., Hohmann, A. G., & Piomelli, D. (2010) · Neuroscience

Cannabis and Cannabinoid ResearchStress Responses and Cortisol

Cited by 89

Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice

Torrens, A., Vozella, V., Huff, H., McNeil, B., Ahmed, F., Ghidini, A., Mahler, S. V., Huestis, M. A., Das, A., & Piomelli, D. (2020) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchForensic Toxicology and Drug Analysis

Cited by 88

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

Brindisi, M., Maramai, S., Gemma, S., Brogi, S., Grillo, A., Di Cesare Mannelli, L., Gabellieri, E., Lamponi, S., Saponara, S., Gorelli, B., et al. (2016) · Journal of Medicinal Chemistry

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 86

Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes

Stella, N., Estellés, A., Siciliano, J., Tencé, M., Desagher, S., Piomelli, D., Glowinski, J., & Prémont, J. (1997) · The Journal of Neuroscience

Adenosine and Purinergic SignalingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 85

Chapter 5 The Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs

Gaetani, S., Dipasquale, P., Romano, A., Righetti, L., Cassano, T., Piomelli, D., & Cuomo, V. (2009) · International Review of Neurobiology

Cannabis and Cannabinoid ResearchMedicinal Plant Extracts Effects

Cited by 83

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice

Cassano, T., Gaetani, S., Macheda, T., Laconca, L., Romano, A., Morgese, M. G., Cimmino, C. S., Chiarotti, F., Bambico, F. R., Gobbi, G., et al. (2011) · Psychopharmacology

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 72

Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive

Sasso, O., Wagner, K., Morisseau, C., Inceoglu, B., Hammock, B. D., & Piomelli, D. (2015) · Pharmacological Research

Pain Mechanisms and TreatmentsCannabis and Cannabinoid Research

Cited by 68

Galantamine potentiates the neuroprotective effect of memantine against NMDA‐induced excitotoxicity

Lopes, J. P., Tarozzo, G., Reggiani, A., Piomelli, D., & Cavalli, A. (2013) · Brain and Behavior

Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

Cited by 64

Effects of peripheral FAAH blockade on NTG-induced hyperalgesia—evaluation of URB937 in an animal model of migraine

Greco, R., Bandiera, T., Mangione, A., Demartini, C., Siani, F., Nappi, G., Sandrini, G., Guijarro, A., Armirotti, A., Piomelli, D., et al. (2015) · Cephalalgia

Migraine and Headache StudiesPain Mechanisms and Treatments

Cited by 63

Pharmacokinetic and pharmacodynamic properties of aerosolized (“vaped”) THC in adolescent male and female rats

Ruiz, C. M., Torrens, A., Lallai, V., Castillo, E., Manca, L., Martinez, M. X., Justeson, D. N., Fowler, C. D., Piomelli, D., & Mahler, S. V. (2021) · Psychopharmacology

Cannabis and Cannabinoid ResearchForensic Toxicology and Drug Analysis

Cited by 56

Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid

Koethe, D., Schreiber, D., Giuffrida, A., Mauss, C., Faulhaber, J., Heydenreich, B., Hellmich, M., Graf, R., Klosterkötter, J., Piomelli, D., et al. (2009) · Journal of Neural Transmission

Sleep and Wakefulness ResearchCannabis and Cannabinoid Research

Cited by 51

AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors

La Rana, G., Russo, R., D'Agostino, G., Sasso, O., Raso, G. M., Iacono, A., Meli, R., Piomelli, D., & Calignano, A. (2008) · Neuropharmacology

Pain Mechanisms and TreatmentsCannabis and Cannabinoid Research

Cited by 42