Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid
Open accessAbstract
This study investigated the role of two fatty acid ethanolamides, the endogenous cannabinoid anandamide and its structural analog oleoylethanolamide in sleep deprivation of human volunteers. Serum and cerebrospinal fluid (CSF) samples were obtained from 20 healthy volunteers before and after a night of sleep deprivation with an interval of about 12 months. We found increased levels of oleoylethanolamide in CSF (P = 0.011) but not in serum (P = 0.068) after 24 h of sleep deprivation. Oleoylethanolamide is an endogenous lipid messenger that is released after neural injury and activates peroxisome proliferator-activated receptor-alpha (PPAR-alpha) with nanomolar potency. Exogenous PPAR-alpha agonists, such as hypolipidemic fibrates and oleoylethanolamide, exert both neuroprotective and neurotrophic effects. Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation.
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Oleoylethanolamide is elevated in cerebrospinal fluid and, to a lesser extent, in serum of sleep-deprived humans.
“Oleoylethanolamide, a potent activator of PPAR-α, is also elevated in CSF, and to a lesser extent in serum of sleep-deprived humans (51).”
From Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) · cites this paper as [51]
Total sleep loss did not alter circulating AEA concentrations.
“others have reported that total sleep loss did not alter circulating AEA concentrations (Koethe et al., 2009)”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Koethe et al., 2009
Total sleep loss increased OEA levels in CSF but not in plasma.
“whereas they instead found increased levels of OEA in CSF but not in plasma (Koethe et al., 2009).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Koethe et al., 2009
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- Authors
- Koethe, D., Schreiber, D., Giuffrida, A., Mauss, C., Faulhaber, J., Heydenreich, B., Hellmich, M., Graf, R., Klosterkötter, J., Piomelli, D., & Leweke, F. M.
- Affiliations
- University of Cologne (DE)
- The University of Texas at San Antonio Health Science Center (US)
- Max Planck Society (DE)
- University of California, Irvine (US)
- Corresponding author
- Leweke, F. Markus
- Venue
- Journal of Neural Transmission
- Published
- 2009-01-10
- Volume
- 116
- Issue
- 3
- Pages
- 301-305
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- PMC
- PMC2757605
- OpenAlex
- W2113545425
- Cited by
- 51
- References
- 23
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 12 · 2020: 3 · 2019: 4 · 2018: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neural Transmission (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Stanley Medical Research Institute (01-315)
- National Alliance for Research on Schizophrenia and Depression
- National Institute on Drug Abuse (R01DA012413, DA12653, DA-12413, R01DA012653)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-073955, R01DK073955)
- National Institute of Neurological Disorders and Stroke (NS 050402)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, oleoylethanolamide, anandamide, endocannabinoids, cerebrospinal fluid, serum, PPARα, neuroprotection, fatty acid ethanolamides
- MeSH terms
- Adult, Arachidonic Acids, Chromatography, High Pressure Liquid, Female, Humans, Male, Middle Aged, Oleic Acids, Sleep Deprivation, Mass Spectrometry, Neuroprotective Agents, PPAR alpha, Lipid Metabolism, Polyunsaturated Alkamides, Young Adult, Cannabinoid Receptor Modulators, Endocannabinoids
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