Cited by 133Memory and Neural MechanismsRegulation of Appetite and ObesityMemory Processes and Influences

Fat-induced satiety factor oleoylethanolamide enhances memory consolidation

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Campolongo, Patrizia, Roozendaal, Benno, Trezza, Viviana, Cuomo, Vincenzo, Astarita, Giuseppe, Fu, Jin, McGaugh, James L., Piomelli, Daniele·2009·Proceedings of the National Academy of Sciences

Abstract

The ability to remember contexts associated with aversive and rewarding experiences provides a clear adaptive advantage to animals foraging in the wild. The present experiments investigated whether hormonal signals released during feeding might enhance memory of recently experienced contextual information. Oleoylethanolamide (OEA) is an endogenous lipid mediator that is released when dietary fat enters the small intestine. OEA mediates fat-induced satiety by engaging type-alpha peroxisome proliferator-activated receptors (PPAR-alpha) in the gut and recruiting local afferents of the vagus nerve. Here we show that post-training administration of OEA in rats improves retention in the inhibitory avoidance and Morris water maze tasks. These effects are blocked by infusions of lidocaine into the nucleus tractus solitarii (NTS) and by propranolol infused into the basolateral complex of the amygdala (BLA). These findings suggest that the memory-enhancing signal generated by OEA activates the brain via afferent autonomic fibers and stimulates noradrenergic transmission in the BLA. The actions of OEA are mimicked by PPAR-alpha agonists and abolished in mutant mice lacking PPAR-alpha. The results indicate that OEA, acting as a PPAR-alpha agonist, facilitates memory consolidation through noradrenergic activation of the BLA, a mechanism that is also critically involved in memory enhancement induced by emotional arousal.

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Crossref · 10.1073/pnas.0903038106

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Authors
Campolongo, P., Roozendaal, B., Trezza, V., Cuomo, V., Astarita, G., Fu, J., McGaugh, J. L., & Piomelli, D.
Affiliations
  • University of California, Irvine (US)
  • University of Groningen (NL)
  • Utrecht University (NL)
  • Sapienza University of Rome (IT)
Venue
Proceedings of the National Academy of Sciences
Published
2009-05-12
Volume
106
Issue
19
Pages
8027-8031
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2092963798
Cited by
133
References
31
Citations by year
2026: 4 · 2025: 2 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 12 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 8
FWCI
4.03
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Iris (Roma Tre University) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-073955, R01DK073955)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
oleoylethanolamide, memory consolidation, PPARα, noradrenergic neurotransmission, basolateral amygdala, nucleus tractus solitarius, passive avoidance, contextual memory, dietary fat, satiety signals, emotional arousal
MeSH terms
Amygdala, Animals, Brain, Dietary Fats, Emotions, Learning, Lipids, Memory, Mice, Inbred C57BL, Neurons, Afferent, Oleic Acids, Propranolol, Rats, Sprague-Dawley, Rats, Wistar, Maze Learning, PPAR alpha, Mice, Rats, Endocannabinoids

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