Fat-induced satiety factor oleoylethanolamide enhances memory consolidation
Open accessAbstract
The ability to remember contexts associated with aversive and rewarding experiences provides a clear adaptive advantage to animals foraging in the wild. The present experiments investigated whether hormonal signals released during feeding might enhance memory of recently experienced contextual information. Oleoylethanolamide (OEA) is an endogenous lipid mediator that is released when dietary fat enters the small intestine. OEA mediates fat-induced satiety by engaging type-alpha peroxisome proliferator-activated receptors (PPAR-alpha) in the gut and recruiting local afferents of the vagus nerve. Here we show that post-training administration of OEA in rats improves retention in the inhibitory avoidance and Morris water maze tasks. These effects are blocked by infusions of lidocaine into the nucleus tractus solitarii (NTS) and by propranolol infused into the basolateral complex of the amygdala (BLA). These findings suggest that the memory-enhancing signal generated by OEA activates the brain via afferent autonomic fibers and stimulates noradrenergic transmission in the BLA. The actions of OEA are mimicked by PPAR-alpha agonists and abolished in mutant mice lacking PPAR-alpha. The results indicate that OEA, acting as a PPAR-alpha agonist, facilitates memory consolidation through noradrenergic activation of the BLA, a mechanism that is also critically involved in memory enhancement induced by emotional arousal.
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Systemic administration of OEA to rats, resulting in elevated OEA plasma levels as seen in PTSD patients, improved memory of aversive training experiences.
“The systemic administration of OEA to rats, resulting in elevated OEA plasma levels as seen in our PTSD patients, improved memory of aversive training experiences [46].”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [46]
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- Authors
- Campolongo, P., Roozendaal, B., Trezza, V., Cuomo, V., Astarita, G., Fu, J., McGaugh, J. L., & Piomelli, D.
- Affiliations
- University of California, Irvine (US)
- University of Groningen (NL)
- Utrecht University (NL)
- Sapienza University of Rome (IT)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-05-12
- Volume
- 106
- Issue
- 19
- Pages
- 8027-8031
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2683095
- OpenAlex
- W2092963798
- Cited by
- 133
- References
- 31
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 12 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 8
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Iris (Roma Tre University) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-073955, R01DK073955)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- oleoylethanolamide, memory consolidation, PPARα, noradrenergic neurotransmission, basolateral amygdala, nucleus tractus solitarius, passive avoidance, contextual memory, dietary fat, satiety signals, emotional arousal
- MeSH terms
- Amygdala, Animals, Brain, Dietary Fats, Emotions, Learning, Lipids, Memory, Mice, Inbred C57BL, Neurons, Afferent, Oleic Acids, Propranolol, Rats, Sprague-Dawley, Rats, Wistar, Maze Learning, PPAR alpha, Mice, Rats, Endocannabinoids
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