Conrad, Marcus

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell

Ferroptosis and cancer prognosisIron Metabolism and Disorders

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 4,293

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 3,732

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 3,341

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology

Ferroptosis and cancer prognosisAntioxidant Activity and Oxidative Stress

Cited by 3,029

Role of GPX4 in ferroptosis and its pharmacological implication

Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine

Ferroptosis and cancer prognosisSelenium in Biological Systems

Cited by 1,520

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 1,470

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyFerroptosis and cancer prognosis

Cited by 672

Regulated necrosis: disease relevance and therapeutic opportunities

Conrad, M., Angeli, J. P. F., Vandenabeele, P., & Stockwell, B. R. (2016) · Nature Reviews Drug Discovery

Cell death mechanisms and regulationFerroptosis and cancer prognosis

Cited by 630

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., Conrad, M., Turker, M. Z., Gao, M., Jiang, X., et al. (2016) · Nature Nanotechnology

Ferroptosis and cancer prognosisNanoplatforms for cancer theranostics

Cited by 622

Ferroptosis Inhibition: Mechanisms and Opportunities

Angeli, J. P. F., Shah, R., Pratt, D. A., & Conrad, M. (2017) · Trends in Pharmacological Sciences

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 563

Regulation of lipid peroxidation and ferroptosis in diverse species

Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development

Ferroptosis and cancer prognosisAntioxidant Activity and Oxidative Stress

Cited by 544

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, M., Jakupoglu, C., Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., Beck, H., Hatzopoulos, A. K., Just, U., Sinowatz, F., et al. (2004) · Molecular and Cellular Biology

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 485

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Carlson, B. A., Tobe, R., Yefremova, E., Tsuji, P. A., Hoffmann, V. J., Schweizer, U., Gladyshev, V. N., Hatfield, D. L., & Conrad, M. (2016) · Redox Biology

Selenium in Biological SystemsAntioxidant Activity and Oxidative Stress

Cited by 316

Activation of lysosomal iron triggers ferroptosis in cancer

Cañeque, T., Baron, L., Müller, S., Carmona, A., Colombeau, L., Versini, A., Solier, S., Gaillet, C., Sindikubwabo, F., Sampaio, J. L., et al. (2025) · Nature

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 287

System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

Mandal, P. K., Seiler, A., Perisic, T., Kölle, P., Banjac Canak, A., Förster, H., Weiss, N., Kremmer, E., Lieberman, M. W., Bannai, S., et al. (2010) · Journal of Biological Chemistry

Sulfur Compounds in BiologyRedox biology and oxidative stress

Cited by 269

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Wirth, E. K., Conrad, M., Winterer, J., Wozny, C., Carlson, B. A., Roth, S., Schmitz, D., Bornkamm, G. W., Coppola, V., Tessarollo, L., et al. (2010) · The FASEB Journal

Selenium in Biological SystemsOrganoselenium and organotellurium chemistry

Cited by 237

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Van Coillie, S., Van San, E., Goetschalckx, I., Wiernicki, B., Mukhopadhyay, B., Tonnus, W., Choi, S. M., Roelandt, R., Dumitrascu, C., Lamberts, L., et al. (2022) · Nature Communications

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 186

Targeting ferroptosis protects against multiorgan dysfunction and death.

VandenBerghe, T., Coillie, S. V., Goetschalckx, I., Wiernicki, B., Mukhopadhyay, B., Tonnus, W., San, E. V., Choi, S. M., Roelandt, R., Dumitrascu, C., et al. (2021) · Nature Communications

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 186

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Alborzinia, H., Chen, Z., Yildiz, U., Freitas, F. P., Vogel, F. C. E., Varga, J. P., Batani, J., Bartenhagen, C., Schmitz, W., Büchel, G., et al. (2023) · EMBO Molecular Medicine

Ferroptosis and cancer prognosisNeuroblastoma Research and Treatments

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Phosphoinositide 3-Kinases Upregulate System x c − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M.-A., Halatsch, M.-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., et al. (2014) · Antioxidants & Redox Signaling

Amino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

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