Medema, Jan Paul

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

The consensus molecular subtypes of colorectal cancer

Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 5,170

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010) · Nature Cell Biology

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 1,804

Sequential cancer mutations in cultured human intestinal stem cells

Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature

Cancer Cells and MetastasisGenetic factors in colorectal cancer

Cited by 1,067

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 1,002

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

De Sousa E Melo, F., Wang, X., Jansen, M., Fessler, E., Trinh, A., de Rooij, L. P. M. H., de Jong, J. H., de Boer, O. J., van Leersum, R., Bijlsma, M. F., et al. (2013) · Nature Medicine

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

Cited by 771

Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol

Mullauer, F. B., Kessler, J. H., & Medema, J. P. (2009) · PLoS ONE

Natural product bioactivities and synthesisPhytochemical Studies and Bioactivities

Cited by 688

Cancer stem cell niche: the place to be

Borovski, T., De Sousa E Melo, F., Vermeulen, L., & Medema, J. P. (2011) · Cancer Research

Cancer Cells and MetastasisMesenchymal stem cell research

Cited by 518

Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: A retrospective, pooled biomarker study

Domingo, E., Freeman-Mills, L., Rayner, E., Glaire, M., Briggs, S., Vermeulen, L., Fessler, E., Medema, J. P., Boot, A., Morreau, H., et al. (2016) · The Lancet Gastroenterology & Hepatology

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

Cited by 308

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., Warmerdam, D. O., Kakkar, V., Moreno, L. F., Vieira Braga, F. A., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 211

Practical and robust identification of molecular subtypes in colorectal cancer by immunohistochemistry

Trinh, A., Trumpi, K., De Sousa E Melo, F., Wang, X., de Jong, J. H., Fessler, E., Kuppen, P. J. K., Reimers, M. S., Swets, M., Koopman, M., et al. (2017) · Clinical Cancer Research

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 180

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., De Sousa E Melo, F., Prasetyanti, P. R., IJspeert, J. E., Franitza, M., et al. (2016) · EMBO Molecular Medicine

TGF-β signaling in diseasesColorectal Cancer Treatments and Studies

Cited by 159

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Lenos, K. J., Bach, S., Ferreira Moreno, L., ten Hoorn, S., Sluiter, N. R., Bootsma, S., Vieira Braga, F. A., Nijman, L. E., van den Bosch, T., Miedema, D. M., et al. (2022) · Nature Communications

Intraperitoneal and Appendiceal MalignanciesColorectal Cancer Treatments and Studies

Cited by 125

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

Vellinga, T. T., den Uil, S., Rinkes, I. H. B., Marvin, D., Ponsioen, B., Alvarez-Varela, A., Fatrai, S., Scheele, C., Zwijnenburg, D. A., Snippert, H., et al. (2016) · Oncogene

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 115

Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

Di Franco, S., Bianca, P., Sardina, D. S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L. R., Lo Iacono, M., Pillitteri, I., et al. (2021) · Nature Communications

Cancer Cells and MetastasisCancer, Lipids, and Metabolism

Cited by 80

Targeting the Colorectal Cancer Stem Cell

Medema, J. P. (2017) · New England Journal of Medicine

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 63

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

Ramesh, P., Lannagan, T. R. M., Jackstadt, R., Atencia Taboada, L., Lansu, N., Wirapati, P., van Hooff, S. R., Dekker, D., Pritchard, J., Kirov, A. B., et al. (2021) · Cell Death & Differentiation

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 52

Neoadjuvant chemotherapy affects molecular classification of colorectal tumors

Trumpi, K., Ubink, I., Trinh, A., Djafarihamedani, M., Jongen, J. M., Govaert, K. M., Elias, S. G., van Hooff, S. R., Medema, J. P., Lacle, M. M., et al. (2017) · Oncogenesis

Colorectal Cancer Treatments and StudiesCancer Cells and Metastasis

Cited by 46

AKT3 expression in mesenchymal colorectal cancer cells drives growth and is associated with epithelial-mesenchymal transition

Buikhuisen, J. Y., Gomez Barila, P. M., Torang, A., Dekker, D., de Jong, J. H., Cameron, K., Vitale, S., Stassi, G., van Hooff, S. R., Castro, M. A. A., et al. (2021) · Cancers

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 33

Interconnectivity between molecular subtypes and tumor stage in colorectal cancer

Coebergh van den Braak, R. R. J., ten Hoorn, S., Sieuwerts, A. M., Tuynman, J. B., Smid, M., Wilting, S. M., Martens, J. W. M., Punt, C. J. A., Foekens, J. A., Medema, J. P., et al. (2020) · BMC Cancer

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 27

Consensus molecular subtype transition during progression of colorectal cancer

van de Weerd, S., Torang, A., Zwager, L. W., Koelink, P. J., Koster, J., Bastiaansen, B. A., Lammers, V., Longobardi, C., Roodhart, J. M., van Krieken, J. H., et al. (2023) · The Journal of Pathology

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 6