Sanacora, Gerard

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 422

Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

Krystal, J. H., Sanacora, G., & Duman, R. S. (2013) · Biological Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 406

Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent: Double-Blind, Randomized Study (ASPIRE I)

Fu, D.-J., Ionescu, D. F., Li, X., Lane, R., Lim, P., Sanacora, G., Hough, D., Manji, H., Drevets, W. C., & Canuso, C. M. (2020) · The Journal of Clinical Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 376

Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial

Coric, V., Taskiran, S., Pittenger, C., Wasylink, S., Mathalon, D. H., Valentine, G., Saksa, J., Wu, Y.-T., Gueorguieva, R., Sanacora, G., et al. (2005) · Biological Psychiatry

Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Cited by 314

Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2)

Wajs, E., Aluisio, L., Holder, R., Daly, E. J., Lane, R., Lim, P., George, J. E., Morrison, R. L., Sanacora, G., Young, A. H., et al. (2020) · The Journal of Clinical Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 308

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

Voleti, B., Navarria, A., Liu, R.-J., Banasr, M., Li, N., Terwilliger, R., Sanacora, G., Eid, T., Aghajanian, G., & Duman, R. S. (2013) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 264

Intravenous arketamine for treatment-resistant depression: open-label pilot study

Leal, G. C., Bandeira, I. D., Correia-Melo, F. S., Telles, M., Mello, R. P., Vieira, F., Lima, C. S., Jesus-Nunes, A. P., Guerreiro-Costa, L. N. F., Marback, R. F., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 257

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

Sanacora, G., & Banasr, M. (2013) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 239

Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects

Sanacora, G., Smith, M. A., Pathak, S., Su, H.-L., Boeijinga, P. H., McCarthy, D. J., & Quirk, M. C. (2014) · Molecular Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 236

The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

Abdallah, C. G., De Feyter, H. M., Averill, L. A., Jiang, L., Averill, C. L., Chowdhury, G. M. I., Purohit, P., de Graaf, R. A., Esterlis, I., Juchem, C., et al. (2018) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 229

A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia

Krystal, A. D., Pizzagalli, D. A., Smoski, M., Mathew, S. J., Nurnberger, J., Lisanby, S. H., Iosifescu, D., Murrough, J. W., Yang, H., Weiner, R. D., et al. (2020) · Nature Medicine

Neuropeptides and Animal PhysiologyTreatment of Major Depression

Cited by 227

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2018) · Pharmacology & Therapeutics

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 219

Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients

Laje, G., Lally, N., Mathews, D., Brutsche, N., Chemerinski, A., Akula, N., Kelmendi, B., Simen, A., McMahon, F. J., Sanacora, G., et al. (2012) · Biological Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 213

KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS

Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 206

Glutamate Metabolism in Major Depressive Disorder

Abdallah, C. G., Jiang, L., De Feyter, H. M., Fasula, M., Krystal, J. H., Rothman, D. L., Mason, G. F., & Sanacora, G. (2014) · American Journal of Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 200

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

Chowdhury, G. M. I., Zhang, J., Thomas, M., Banasr, M., Ma, X., Pittman, B., Bristow, L., Schaeffer, E., Duman, R. S., Rothman, D. L., et al. (2017) · Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 197

The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 197

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

Abdallah, C. G., Averill, L. A., Gueorguieva, R., Goktas, S., Purohit, P., Ranganathan, M., Sherif, M., Ahn, K.-H., D’Souza, D. C., Formica, R., et al. (2020) · Neuropsychopharmacology

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 184

Riluzole in the Treatment of Mood and Anxiety Disorders

Pittenger, C., Coric, V., Banasr, M., Bloch, M., Krystal, J. H., & Sanacora, G. (2008) · CNS Drugs

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 177

A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems

Wilkinson, S. T., & Sanacora, G. (2019) · Drug Discovery Today

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 173

Brain–phenotype models fail for individuals who defy sample stereotypes

Greene, A. S., Shen, X., Noble, S., Horien, C., Hahn, C. A., Arora, J., Tokoglu, F., Spann, M. N., Carrión, C. I., Barron, D. S., et al. (2022) · Nature

Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and Applications

Cited by 167

Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder

Bloch, M. H., Wasylink, S., Landeros-Weisenberger, A., Panza, K. E., Billingslea, E., Leckman, J. F., Krystal, J. H., Bhagwagar, Z., Sanacora, G., & Pittenger, C. (2012) · Biological Psychiatry

Obsessive-Compulsive Spectrum DisordersTreatment of Major Depression

Cited by 162

Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders?

Sanacora, G., & Schatzberg, A. F. (2015) · Neuropsychopharmacology

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 160

Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression

Esterlis, I., DellaGioia, N., Pietrzak, R. H., Matuskey, D., Nabulsi, N., Abdallah, C. G., Yang, J., Pittenger, C., Sanacora, G., Krystal, J. H., et al. (2018) · Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 148