Cited by 200Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Glutamate Metabolism in Major Depressive Disorder

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Abdallah, Chadi G., Jiang, Lihong, De Feyter, Henk M., Fasula, Madonna, Krystal, John H., Rothman, Douglas L., Mason, Graeme F., Sanacora, Gerard·2014·American Journal of Psychiatry

Abstract

Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.

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Crossref · 10.1176/appi.ajp.2014.14010067

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  • The alteration of EPC acutely post injection may reflect a transient reduction in postsynaptic activation due to blockade of postsynaptic NMDAR by ketamine and its metabolite, norketamine.

    “The alteration of EPC acutely post injection may reflect a transient reduction in postsynaptic activation [9] due to blockade of postsynaptic NMDAR by ketamine and its metabolite, norketamine.”

    From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [9]

    The Discussion (page unavailable) proposes reduced glutamatergic synaptic strength in depressed subjects and links synaptic strength to AMPA and NMDA receptor transmission. That lends support to the cited idea of reduced postsynaptic activation, but the paper does not address a transient change after ketamine injection; its ketamine mentions appear in the References. (LLM, conf=0.78)

    Experimental — accuracy not yet measured
  • 13C MRS is a unique, noninvasive method to measure neurotransmitter cycling and cell-specific neuroenergetics.

    “Carbon-13 magnetic resonance spectroscopy ( 13 C MRS) is a unique, noninvasive method to measure neurotransmitter cycling and cell-specific neuroenergetics [8][9][10].”

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Authors
Abdallah, C. G., Jiang, L., De Feyter, H. M., Fasula, M., Krystal, J. H., Rothman, D. L., Mason, G. F., & Sanacora, G.
Affiliations
  • Yale University (US)
  • From the Department of Psychiatry, the Department of Diagnostic Imaging, and the Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Conn.; the Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven; and the Clinical Neuroscience Division, National Center for PTSD, West Haven, Conn.
Venue
American Journal of Psychiatry
Published
2014-12-01
Volume
171
Issue
12
Pages
1320-1327
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2094998611
Cited by
200
References
40
Citations by year
2026: 13 · 2025: 13 · 2024: 18 · 2023: 21 · 2022: 20 · 2021: 36 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 4
FWCI
8.75
Type
journal article
Language
en
Open access
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5k23mh101498-05)
  • National Institute of Mental Health (K23MH-101498(, R01MH071676, K02MH076222)
  • National Institute on Drug Abuse (R01DA021785, T32DA022975)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
glutamate metabolism, major depressive disorder, glutamate dysfunction, neuroimaging
MeSH terms
Adult, Aged, Carbon Isotopes, Citric Acid Cycle, Depressive Disorder, Major, Major Depressive Disorder, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Mitochondria, Models, Biological, Magnetic Resonance Spectroscopy, Occipital Lobe, Protons, Glutamic Acid, Young Adult, Neuroimaging

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