Hen, René

Neuronal plasticity and antidepressant actions

Castrén, E., & Hen, R. (2013) · Trends in Neurosciences

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 243

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

Quesseveur, G., David, D. J., Gaillard, M. C., Pla, P., Wu, M. V., Nguyen, H. T., Nicolas, V, Auregan, G., David, I., Dranovsky, A., et al. (2013) · Translational Psychiatry

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 235

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

Samuels, B. A., Anacker, C., Hu, A., Levinstein, M. R., Pickenhagen, A., Tsetsenis, T., Madroñal, N., Donaldson, Z. R., Drew, L. J., Dranovsky, A., et al. (2015) · Nature Neuroscience

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 200

Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety

Richardson-Jones, J. W., Craige, C. P., Nguyen, T. H., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Guiard, B. P., Beck, S. G., Hen, R., et al. (2011) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 192

Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus

Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A. (2012) · Hippocampus

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 188

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R. (2016) · Hippocampus

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 169

Neuroanatomic differences associated with stress susceptibility and resilience

Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 167

Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice

Deltheil, T., Guiard, B. P., Cerdan, J., David, D. J., Tanaka, K. F., Repérant, C., Guilloux, J.-P., Coudoré, F., Hen, R., & Gardier, A. M. (2008) · Neuropharmacology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 153

Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood

Kheirbek, M. A., & Hen, R. (2011) · Neuropsychopharmacology

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 140

Human 5-HT5 receptors: the 5-HT5A receptor is functional but the 5-HT5B receptor was lost during mammalian evolution

Grailhe, R., Grabtree, G. W., & Hen, R. (2001) · European Journal of Pharmacology

Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Cited by 130

Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons

Boldrini, M., Galfalvy, H., Dwork, A. J., Rosoklija, G. B., Trencevska-Ivanovska, I., Pavlovski, G., Hen, R., Arango, V., & Mann, J. J. (2019) · Biological Psychiatry

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 116

Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia

Gaisler-Salomon, I., Miller, G. M., Chuhma, N., Lee, S., Zhang, H., Ghoddoussi, F., Lewandowski, N., Fairhurst, S., Wang, Y., Conjard-Duplany, A., et al. (2009) · Neuropsychopharmacology

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 86

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain

Tartt, A. N., Fulmore, C. A., Liu, Y., Rosoklija, G. B., Dwork, A. J., Arango, V., Hen, R., Mann, J. J., & Boldrini, M. (2018) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 69

An exploratory study of combination buspirone and melatonin SR in Major Depressive Disorder (MDD): A possible role for neurogenesis in drug discovery

Fava, M., Targum, S. D., Nierenberg, A. A., Bleicher, L. S., Carter, T. A., Wedel, P. C., Hen, R., Gage, F. H., & Barlow, C. (2012) · Journal of Psychiatric Research

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 67

Add neurons, subtract anxiety

Kheirbek, M. A., & Hen, R. (2014) · Scientific American

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 47

Genetic approaches for understanding the role of serotonin receptors in mood and behavior

Donaldson, Z. R., Nautiyal, K. M., Ahmari, S. E., & Hen, R. (2013) · Current Opinion in Neurobiology

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 42

Structural and functional conservation of serotonin receptors throughout evolution

Hen, R. (1993) · Comparative Molecular Neurobiology

Receptor Mechanisms and SignalingNeurotransmitter Receptor Influence on Behavior

Cited by 37

Loss of adult 5-HT1A autoreceptors results in a paradoxical Anxiogenic response to antidepressant treatment

Turcotte-Cardin, V., Vahid-Ansari, F., Luckhart, C., Daigle, M., Geddes, S. D., Tanaka, K. F., Hen, R., James, J., Merali, Z., Béïque, J.-C., et al. (2019) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 36

A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin

Mendez‐David, I., David, D. J., Deloménie, C., Tritschler, L., Beaulieu, J., Colle, R., Corruble, E., Gardier, A. M., & Hen, R. (2023) · Hippocampus

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 15

5-HT4 Receptor Subtype, β-Arrestin Level, and Rapid-Onset Effects of Antidepressant Drugs

Mendez-David, I., David, D. J., Guilloux, J.-P., Hen, R., & Gardier, A. M. (2015) · Neuromethods

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 4