Cited by 169Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

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Drew, Liam J., Kheirbek, Mazen A., Luna, Victor M., Denny, Christine A., Cloidt, Megan A., Wu, Melody V., Jain, Swati, Scharfman, Helen E. +1 more·2016·Hippocampus

Abstract

Robust incorporation of new principal cells into pre-existing circuitry in the adult mammalian brain is unique to the hippocampal dentate gyrus (DG). We asked if adult-born granule cells (GCs) might act to regulate processing within the DG by modulating the substantially more abundant mature GCs. Optogenetic stimulation of a cohort of young adult-born GCs (0 to 7 weeks post-mitosis) revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs. Natural manipulation of neurogenesis by aging-to decrease it-and housing in an enriched environment-to increase it-strongly affected the levels of inhibition. We also demonstrated that elevating activity in adult-born GCs in awake behaving animals reduced the overall number of mature GCs activated by exploration. These data suggest that inhibitory modulation of mature GCs may be an important function of adult-born hippocampal neurons. © 2015 Wiley Periodicals, Inc.

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Authors
Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R.
Affiliations
  • New York State Psychiatric Institute (US)
  • Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Hen, René
Venue
Hippocampus
Publisher
Wiley
Published
2016-02-08
Volume
26
Issue
6
Pages
763-778
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
OpenAlex
W2218526093
Cited by
169
References
67
Citations by year
2026: 8 · 2025: 14 · 2024: 13 · 2023: 11 · 2022: 17 · 2021: 14 · 2020: 21 · 2019: 30 · 2018: 14 · 2017: 18 · 2016: 9
FWCI
5.54
Type
journal article
Language
en
Open access
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (R01 NS‐081203 (to H.E.S., R.H., L.J.D.))
  • National Institute of Mental Health (K01 MH‐099371 (to M.A.K.))
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult neurogenesis, dentate gyrus, granule cells, GABAergic interneurons, optogenetics, aging, environmental enrichment, exploratory behavior, inhibitory modulation
MeSH terms
Animals, Environment, Exploratory Behavior, Female, gamma-Aminobutyric Acid, Housing, Animal, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Cohort Studies, Proto-Oncogene Proteins c-fos, Dentate Gyrus, Adult Stem Cells, Neurogenesis, Mice, 129 Strain, Neural Stem Cells, Optogenetics

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