Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
Open accessAbstract
Robust incorporation of new principal cells into pre-existing circuitry in the adult mammalian brain is unique to the hippocampal dentate gyrus (DG). We asked if adult-born granule cells (GCs) might act to regulate processing within the DG by modulating the substantially more abundant mature GCs. Optogenetic stimulation of a cohort of young adult-born GCs (0 to 7 weeks post-mitosis) revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs. Natural manipulation of neurogenesis by aging-to decrease it-and housing in an enriched environment-to increase it-strongly affected the levels of inhibition. We also demonstrated that elevating activity in adult-born GCs in awake behaving animals reduced the overall number of mature GCs activated by exploration. These data suggest that inhibitory modulation of mature GCs may be an important function of adult-born hippocampal neurons. © 2015 Wiley Periodicals, Inc.
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Adult-generated neurons form connections with PV+ inhibitory interneurons.
“Additionally, adult-generated neurons also form connections with PV+ inhibitory interneurons (38; 39).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [39]
Immature neurons project to interneurons in the dentate gyrus.
“Immature neurons project to interneurons in the DG and reports have documented the role of interneurons in modulating neuronal circuitry controlling hippocampal neurogenesis, as well as the activity of new neurons in vivo (38;39).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [39]
Interneurons modulate neuronal circuitry controlling hippocampal neurogenesis and the activity of new neurons in vivo.
“Immature neurons project to interneurons in the DG and reports have documented the role of interneurons in modulating neuronal circuitry controlling hippocampal neurogenesis, as well as the activity of new neurons in vivo (38;39).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [39]
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RetractedIncreasing adult-born neurons protects mice from epilepsyPreprint
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- Authors
- Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R.
- Affiliations
- New York State Psychiatric Institute (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Hen, René
- ORCID
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2016-02-08
- Volume
- 26
- Issue
- 6
- Pages
- 763-778
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC4867135
- OpenAlex
- W2218526093
- Cited by
- 169
- References
- 67
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 11 · 2022: 17 · 2021: 14 · 2020: 21 · 2019: 30 · 2018: 14 · 2017: 18 · 2016: 9
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01 NS‐081203 (to H.E.S., R.H., L.J.D.))
- National Institute of Mental Health (K01 MH‐099371 (to M.A.K.))
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus, granule cells, GABAergic interneurons, optogenetics, aging, environmental enrichment, exploratory behavior, inhibitory modulation
- MeSH terms
- Animals, Environment, Exploratory Behavior, Female, gamma-Aminobutyric Acid, Housing, Animal, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Cohort Studies, Proto-Oncogene Proteins c-fos, Dentate Gyrus, Adult Stem Cells, Neurogenesis, Mice, 129 Strain, Neural Stem Cells, Optogenetics
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