Tsai, Li-Huei

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

Tseng, H.-C., Zhou, Y., Shen, Y., & Tsai, L.-H. (2002) · FEBS Letters

Alzheimer's disease research and treatmentsCalpain Protease Function and Regulation

Cited by 198

Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble

Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., et al. (2020) · Nature Neuroscience

Memory and Neural MechanismsGenomics and Chromatin Dynamics

Cited by 159

Insights into Alzheimer’s disease from single-cell genomic approaches

Murdock, M. H., & Tsai, L.-H. (2023) · Nature Neuroscience

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 148

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., et al. (2023) · Cell

DNA Repair MechanismsAlzheimer's disease research and treatments

Cited by 130

Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease

Welch, G., & Tsai, L. (2022) · The EMBO Reports

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 129

Noninvasive 40-hz light flicker to recruit microglia and reduce amyloid beta load

Singer, A. C., Martorell, A. J., Douglas, J. M., Abdurrob, F., Attokaren, M. K., Tipton, J., Mathys, H., Adaikkan, C., & Tsai, L.-H. (2018) · Nature Protocols

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 127

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

Gräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H. (2013) · The Journal of Neuroscience

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 124

Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity

Frank, C. L., & Tsai, L.-H. (2009) · Neuron

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 118

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Nott, A., Cheng, J., Gao, F., Lin, Y.-T., Gjoneska, E., Ko, T., Minhas, P., Zamudio, A. V., Meng, J., Zhang, F., et al. (2016) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersFOXO transcription factor regulation

Cited by 110

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

Lee, S.-I., Jeong, W., Lim, H., Cho, S., Lee, H., Jang, Y., Cho, J., Bae, S., Lin, Y.-T., Tsai, L.-H., et al. (2021) · Stem Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 105

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Wagner, F. F., Zhang, Y.-L., Fass, D. M., Joseph, N., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., et al. (2015) · Chemical Science

Histone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative Diseases

Cited by 104

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Colombo, G., Cubero, R. J. A., Kanari, L., Venturino, A., Schulz, R., Scolamiero, M., Agerberg, J., Mathys, H., Tsai, L.-H., Chachólski, W., et al. (2022) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsCell Image Analysis Techniques

Cited by 100

MEF2 is a Key Regulator of Cognitive Potential and Confers Resilience to Neurodegeneration

Barker, S. J., Raju, R. M., Milman, N. E. P., Wang, J., Davila-Velderrain, J., Gunter-Rahman, F., Parro, C. C., Bozzelli, P. L., Abdurrob, F., Abdelaal, K., et al. (2021) · Science Translational Medicine

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 96

Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Meharena, H. S., Marco, A., Dileep, V., Lockshin, E. R., Akatsu, G. Y., Mullahoo, J., Watson, L. A., Ko, T., Guerin, L. N., Abdurrob, F., et al. (2022) · Cell Stem Cell

Down syndrome and intellectual disability researchTelomeres, Telomerase, and Senescence

Cited by 92

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., et al. (2022) · Science Advances

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 84

Nanoparticle-mediated delivery of anti-PU.1 siRNA via localized intracisternal administration reduces neuroinflammation

Ralvenius, W. T., Andresen, J. L., Huston, M. M., Penney, J., Bonner, J. M., Fenton, O. S., Langer, R., & Tsai, L. (2024) · Advanced Materials

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 78

PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

Narayan, P., Sienski, G., Bonner, J. M., Lin, Y.-T., Seo, J., Baru, V., Haque, A., Milo, B., Akay, L. A., Graziosi, A., et al. (2020) · Cell Reports

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 75

Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models

Shim, H. S., Horner, J. W., Wu, C.-J., Li, J., Lan, Z. D., Jiang, S., Xu, X., Hsu, W.-H., Zal, T., Flores, I. I., et al. (2021) · Nature Aging

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 73

Profiling DNA break sites and transcriptional changes in response to contextual fear learning

Stott, R. T., Kritsky, O., & Tsai, L.-H. (2021) · PLOS ONE

Memory and Neural MechanismsDNA Repair Mechanisms

Cited by 62

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer’s Disease

Vance, J. M., Farrer, L. A., Huang, Y., Cruchaga, C., Hyman, B. T., Pericak‐Vance, M. A., Goate, A. M., Greicius, M. D., Griswold, A. J., Haines, J. L., et al. (2024) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons

von Maydell, D., Wright, S. E., Pao, P.-C., Staab, C., King, O., Spitaleri, A., Bonner, J. M., Liu, L., Yu, C. J., Chiu, C.-C., et al. (2025) · Nature

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 35

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Zhao, W.-N., Ghosh, B., Tyler, M., Lalonde, J., Joseph, N. F., Kosaric, N., Fass, D. M., Tsai, L.-H., Mazitschek, R., & Haggarty, S. J. (2018) · ACS Chemical Neuroscience

Histone Deacetylase Inhibitors ResearchNeuroscience and Neuropharmacology Research

Cited by 35

Histone Deacetylases 1 and 2 in Memory Function

Pao, P.-C., & Tsai, L.-H. (2022) · ACS Chemical Neuroscience

Histone Deacetylase Inhibitors ResearchMemory and Neural Mechanisms

Cited by 34

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba‐Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 33