A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
Open accessAbstract
Caloric restriction (CR) is a dietary regimen known to promote lifespan by slowing down the occurrence of age-dependent diseases. The greatest risk factor for neurodegeneration in the brain is age, from which follows that CR might also attenuate the progressive loss of neurons that is often associated with impaired cognitive capacities. In this study, we used a transgenic mouse model that allows for a temporally and spatially controlled onset of neurodegeneration to test the potentially beneficial effects of CR. We found that in this model, CR significantly delayed the onset of neurodegeneration and synaptic loss and dysfunction, and thereby preserved cognitive capacities. Mechanistically, CR induced the expression of the known lifespan-regulating protein SIRT1, prompting us to test whether a pharmacological activation of SIRT1 might recapitulate CR. We found that oral administration of a SIRT1-activating compound essentially replicated the beneficial effects of CR. Thus, SIRT1-activating compounds might provide a pharmacological alternative to the regimen of CR against neurodegeneration and its associated ailments.
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SIRT1 level is increased by dietary restriction in multiple brain regions, including hypothalamus, hippocampus, and cortex.
“Several lines of evidence have shown that SIRT1 level is increased by DR in multiple brain regions, including hypothalamus, hippocampus, and cortex [103,104,161,162].”
From Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link (2019) · cites this paper as [162]
The Results section reports markedly increased SIRT1 protein expression in the hippocampus of caloric-restricted CK-p25 mice compared with mice fed ad libitum. The passages found do not establish an increase in the hypothalamus or cortex, so this paper supports only the hippocampal part of the claim. (LLM, conf=0.88)
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- Authors
- Gräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H.
- Affiliations
- Howard Hughes Medical Institute (US)
- Broad Institute (US)
- Corresponding author
- Tsai, Li-Huei
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-05-22
- Volume
- 33
- Issue
- 21
- Pages
- 8951-8960
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3775567
- OpenAlex
- W2085431927
- Cited by
- 124
- References
- 46
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 18 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 2
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Howard Hughes Medical Institute
- Glenn Foundation for Medical Research
- Fondation pour la Recherche Médicale
- National Institutes of Health (AG027916, PO1 AG027916)
- National Institute on Aging (P01AG027916)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- caloric restriction, SIRT1, neurodegeneration, synaptic loss, cognitive impairment, lifespan extension, SIRT1 activators, transgenic mouse model, age-related neurodegeneration, dietary intervention
- MeSH terms
- Analysis of Variance, Animals, Atrophy, Brain, Cognition Disorders, Disease Models, Animal, Double-Blind Method, Female, Male, Memory Disorders, Mice, Transgenic, Nerve Tissue Proteins, Phosphopyruvate Hydratase, Phosphotransferases, Piperidines, Synapses, Thiazoles, Vitamin E, Case-Control Studies, Tumor Suppressor Protein p53, Silver Staining, Long-Term Potentiation, Neurodegenerative Diseases, Excitatory Postsynaptic Potentials, Caloric Restriction, Microscopy, Electron, Transmission, Immunoprecipitation, Green Fluorescent Proteins, Cyclin-Dependent Kinase 5, Mice, Sirtuin 1, In Vitro Techniques
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