Tsai, Li-Huei

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology

Mathys, H., Peng, Z., Boix, C. A., Victor, M. B., Leary, N., Babu, S., Abdelhady, G., Jiang, X., Ng, A. P., Ghafari, K., et al. (2023) · Cell

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 495

Modeling Alzheimer’s disease with iPSC-derived brain cells

Penney, J., Ralvenius, W. T., & Tsai, L.-H. (2020) · Molecular Psychiatry

Pluripotent Stem Cells ResearchAlzheimer's disease research and treatments

Cited by 471

Human microglial state dynamics in Alzheimer’s disease progression

Sun, N., Victor, M. B., Park, Y. P., Xiong, X., Scannail, A. N., Leary, N., Prosper, S., Viswanathan, S., Luna, X., Boix, C. A., et al. (2023) · Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 462

Guiding Neuronal Cell Migrations

Marin, O., Valiente, M., Ge, X., & Tsai, L.-H. (2010) · Cold Spring Harbor Perspectives in Biology

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 417

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

Murdock, M. H., Yang, C.-Y., Sun, N., Pao, P.-C., Blanco-Duque, C., Kahn, M. C., Kim, T., Lavoie, N. S., Victor, M. B., Islam, M. R., et al. (2024) · Nature

Cerebrospinal fluid and hydrocephalusAlzheimer's disease research and treatments

Cited by 379

Epigenetic regulation of gene expression in physiological and pathological brain processes

Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 373

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

Gräff, J., Joseph, N. F., Horn, M. E., Samiei, A., Meng, J., Seo, J., Rei, D., Bero, A. W., Phan, T. X., Wagner, F., et al. (2014) · Cell

Memory and Neural MechanismsMemory Processes and Influences

Cited by 357

Single-cell multiregion dissection of Alzheimer’s disease

Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 343

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

Sienski, G., Narayan, P., Bonner, J. M., Kory, N., Boland, S., Arczewska, A. A., Ralvenius, W. T., Akay, L., Lockshin, E., He, L., et al. (2021) · Science Translational Medicine

Alzheimer's disease research and treatmentsLipid metabolism and biosynthesis

Cited by 336

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Sieberts, S. K., Perumal, T. M., Carrasquillo, M. M., Allen, M., Reddy, J. S., Hoffman, G. E., Dang, K. K., Calley, J., Ebert, P. J., Eddy, J., et al. (2020) · Scientific Data

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 318

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Scannail, A. N., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., et al. (2022) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 316

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., Cerit, O., et al. (2022) · Cell stem cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 311

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Wan, Y.-W., Al-Ouran, R., Mangleburg, C. G., Perumal, T. M., Lee, T. V., Allison, K., Swarup, V., Funk, C. C., Gaiteri, C., Allen, M., et al. (2020) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 295

Tau Activation of Microglial cGAS–IFN Reduces MEF2C‐mediated Cognitive Resilience

Udeochu, J. C., Amin, S., Huang, Y., Fan, L., Torres, E. R. S., Carling, G. K., Liu, B., McGurran, H., Coronas-Samano, G., Kauwe, G., et al. (2023) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 289

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., et al. (2008) · Neuron

Histone Deacetylase Inhibitors ResearchCancer-related Molecular Pathways

Cited by 286

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Blanchard, J. W., Bula, M., Davila-Velderrain, J., Akay, L. A., Zhu, L., Frank, A., Victor, M. B., Bonner, J. M., Mathys, H., Lin, Y.-T., et al. (2020) · Nature Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 283

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B., & Tsai, L.-H. (2005) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 277

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

Cruz, J. C., & Tsai, L.-H. (2004) · Trends in Molecular Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 258

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

Dobbin, M. M., Madabhushi, R., Pan, L., Chen, Y., Kim, D., Gao, J., Ahanonu, B., Pao, P.-C., Qiu, Y., Zhao, Y., et al. (2013) · Nature Neuroscience

DNA Repair MechanismsSirtuins and Resveratrol in Medicine

Cited by 250

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Durak, O., Gao, F., Kaeser-Woo, Y. J., Rueda, R., Martorell, A. J., Nott, A., Liu, C. Y., Watson, L. A., & Tsai, L.-H. (2016) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 243

REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease

Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K.-H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y.-T., et al. (2019) · Cell Reports

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 216

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

Pao, P.-C., Patnaik, D., Watson, L. A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H. P., Huang, W.-C., et al. (2020) · Nature Communications

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 216

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 210

Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion

Xiong, X., James, B. T., Boix, C. A., Park, Y. P., Galani, K., Victor, M. B., Sun, N., Hou, L., Ho, L.-L., Mantero, J., et al. (2023) · Cell

Alzheimer's disease research and treatmentsGenomics and Chromatin Dynamics

Cited by 205