Cited by 110Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells

Open access
Suzuki, Ikuo K., Vanderhaeghen, Pierre·2015·Development

Abstract

The human brain is arguably the most complex structure among living organisms. However, the specific mechanisms leading to this complexity remain incompletely understood, primarily because of the poor experimental accessibility of the human embryonic brain. Over recent years, technologies based on pluripotent stem cells (PSCs) have been developed to generate neural cells of various types. While the translational potential of PSC technologies for disease modeling and/or cell replacement therapies is usually put forward as a rationale for their utility, they are also opening novel windows for direct observation and experimentation of the basic mechanisms of human brain development. PSC-based studies have revealed that a number of cardinal features of neural ontogenesis are remarkably conserved in human models, which can be studied in a reductionist fashion. They have also revealed species-specific features, which constitute attractive lines of investigation to elucidate the mechanisms underlying the development of the human brain, and its link with evolution.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1242/dev.120568

Cites

180 of 180 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • WNT signalling effects are stage specific, with divergent roles in cell proliferation and cell type specification depending on temporal and regional expression.

    “For example, in embryogenesis, the effects of WNT signalling are stage specific, and there are divergent roles for WNT signalling in cell proliferation and cell type specification that depend on its temporal and regional expression (for reviews, see REFS 30,31).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Suzuki, I. K., & Vanderhaeghen, P.
Affiliations
Université Libre de Bruxelles (BE)
Corresponding author
Vanderhaeghen, Pierre
Venue
Development
Published
2015-09-15
Volume
142
Issue
18
Pages
3138-3150
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W1911595652
Cited by
110
References
180
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 15 · 2020: 15 · 2019: 17 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 1
FWCI
1.13
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
  • Lirias (submittedVersion)
Funders
  • Waalse Gewest
  • AXA Research Fund
  • Walloon excellence in life sciences and biotechnology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
human brain development, pluripotent stem cells, brain evolution, disease modeling, cell replacement therapy, neuronal differentiation
MeSH terms
Brain, Embryonic Induction, Biological Evolution, Humans, Models, Neurological, Retina, Species Specificity, Neurites, Pluripotent Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review