Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells
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The human brain is arguably the most complex structure among living organisms. However, the specific mechanisms leading to this complexity remain incompletely understood, primarily because of the poor experimental accessibility of the human embryonic brain. Over recent years, technologies based on pluripotent stem cells (PSCs) have been developed to generate neural cells of various types. While the translational potential of PSC technologies for disease modeling and/or cell replacement therapies is usually put forward as a rationale for their utility, they are also opening novel windows for direct observation and experimentation of the basic mechanisms of human brain development. PSC-based studies have revealed that a number of cardinal features of neural ontogenesis are remarkably conserved in human models, which can be studied in a reductionist fashion. They have also revealed species-specific features, which constitute attractive lines of investigation to elucidate the mechanisms underlying the development of the human brain, and its link with evolution.
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WNT signalling effects are stage specific, with divergent roles in cell proliferation and cell type specification depending on temporal and regional expression.
“For example, in embryogenesis, the effects of WNT signalling are stage specific, and there are divergent roles for WNT signalling in cell proliferation and cell type specification that depend on its temporal and regional expression (for reviews, see REFS 30,31).”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [30]
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1 retracted
RETRACTED: NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells
Boles, N. C., Hirsch, S. E., Le, S., Corneo, B., Najm, F. J., Minotti, A. P., Wang, Q., Lotz, S., Tesar, P. J., & Fasano, C. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.026 · Cited by 64 · see citing works
RetractedCerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620 · see citing works
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · see citing works
Organogenesis in a dish: Modeling development and disease using organoid technologies
Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229 · see citing works
Self-organizing optic-cup morphogenesis in three-dimensional culture
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) · Nature · doi:10.1038/nature09941 · Cited by 2,001 · see citing works
Dimos, J. T., Rodolfa, K. T., Niakan, K. K., Weisenthal, L. M., Mitsumoto, H., Chung, W. K., Croft, G. F., Saphier, G., Leibel, R. L., Goland, R., et al. (2008) · Science · doi:10.1126/science.1158799 · Cited by 1,959 · see citing works
Kriks, S., Shim, J., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo‐Reid, L., Auyeung, G., Antonacci, C. L., Buch, A., et al. (2011) · Nature · doi:10.1038/nature10648 · Cited by 1,912 · see citing works
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792 · see citing works
The mechanisms of Hedgehog signalling and its roles in development and disease
Briscoe, J., & Thérond, P. P. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3598 · Cited by 1,751 · see citing works
Soldner, F., Hockemeyer, D., Beard, C., Gao, Q., Bell, G. W., Cook, E. G., Hargus, G., Blak, A., Cooper, O., Mitalipova, M., et al. (2009) · Cell · doi:10.1016/j.cell.2009.02.013 · Cited by 1,615 · see citing works
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565 · see citing works
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504 · see citing works
Self-formation of optic cups and storable stratified neural retina from human ESCs
Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., & Sasai, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.009 · Cited by 1,447 · see citing works
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P., & Kostović, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105108108 · Cited by 1,411 · see citing works
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Modelling schizophrenia using human induced pluripotent stem cells
Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375 · see citing works
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works
Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., & Muotri, A. R. (2010) · Cell · doi:10.1016/j.cell.2010.10.016 · Cited by 1,329 · see citing works
Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity
Kawasaki, H., Mizuseki, K., Nishikawa, S., Kaneko, S., Kuwana, Y., Nakanishi, S., Nishikawa, S., & Sasai, Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00083-0 · Cited by 1,277 · see citing works
Embryo-Derived Stem Cells: Of Mice and Men
Smith, A. G. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.435 · Cited by 1,263 · see citing works
Rakic, P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93934-p · Cited by 1,047 · see citing works
An RNA gene expressed during cortical development evolved rapidly in humans
Pollard, K. S., Salama, S. R., Lambert, N., Lambot, M.-A., Coppens, S., Pedersen, J. S., Katzman, S., King, B., Onodera, C., Siepel, A., et al. (2006) · Nature · doi:10.1038/nature05113 · Cited by 1,005 · see citing works
Self-citationHaubensak, W. E., Attardo, A., Denk, W. T., & Huttner, W. Β. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308600100 · Cited by 1,004 · see citing works
Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999 · see citing works
Derivation of midbrain dopamine neurons from human embryonic stem cells
Perrier, A. L., Tabar, V. S., Barberi, T., Rubio, M. E., Brusés, J. L., Topf, N., Harrison, N. L., & Studer, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404700101 · Cited by 981 · see citing works
Development of the human cerebral cortex: Boulder Committee revisited
Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977 · see citing works
Evolution of the brain and intelligence
ROTH, G., & DICKE, U. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.005 · Cited by 890 · see citing works
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863 · see citing works
New insights into the classification and nomenclature of cortical GABAergic interneurons
DeFelipe, J., López-Cruz, P. L., Benavides-Piccione, R., Bielza, C., Larrañaga, P., Anderson, S., Burkhalter, A., Cauli, B., Fairén, A., Feldmeyer, D., et al. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3444 · Cited by 833 · see citing works
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830 · see citing works
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. C., & Livesey, F. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3041 · Cited by 813 · see citing works
Directed differentiation of telencephalic precursors from embryonic stem cells
Watanabe, K., Kamiya, D., Nishiyama, A., Katayama, T., Nozaki, S., Kawasaki, H., Watanabe, Y., Mizuseki, K., & Sasai, Y. (2005) · Nature Neuroscience · doi:10.1038/nn1402 · Cited by 784 · see citing works
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
Miyata, T., Kawaguchi, A., Saito, K., Kawano, M., Muto, T., & Ogawa, M. (2004) · Development · doi:10.1242/dev.01173 · Cited by 769 · see citing works
Specification of motoneurons from human embryonic stem cells
Li, X. J., Du, Z.-W., Żarnowska, E. D., Pankratz, M. T., Hansen, L., Pearce, R. A., & Zhang, S. (2005) · Nature Biotechnology · doi:10.1038/nbt1063 · Cited by 767 · see citing works
Direct Neural Fate Specification from Embryonic Stem Cells
Tropepe, V., Hitoshi, S., Sirard, C., Mak, T. W., Rossant, J., & van der Kooy, D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00263-x · Cited by 757 · see citing works
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2008 · Cited by 738 · see citing works
Taverna, E., Götz, M., & Huttner, W. Β. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155801 · Cited by 737 · see citing works
Cell Cycle Dependence of Laminar Determination in Developing Neocortex
McConnell, S. K., & Kaznowski, C. E. (1991) · Science · doi:10.1126/science.1925583 · Cited by 712 · see citing works
Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells
Muguruma, K., Nishiyama, A., Kawakami, H., Hashimoto, K., & Sasai, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.051 · Cited by 692 · see citing works
Patterning and plasticity of the cerebral cortex
Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677 · see citing works
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
Elkabetz, Y., Panagiotakos, G., Al Shamy, G., Socci, N. D., Tabar, V., & Studer, L. (2008) · Genes & Development · doi:10.1101/gad.1616208 · Cited by 677 · see citing works
Kirkeby, A., Grealish, S., Wolf, D. A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O., & Parmar, M. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.009 · Cited by 662 · see citing works
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655 · cited 2× · see citing works
“…period could be linked to species-specific properties intrinsic to neural progenitors, such as differential cell cycle control or tuning of self-renewal versus terminal differentiation (Lukaszewicz et al., 2005), but overall the underlying mechanisms remain unknown (Dehay and Kennedy, 2007).”
BackgroundAn intrinsic mechanism of corticogenesis from embryonic stem cells
Gaspard, N., Bouschet, T., Hourez, R., Dimidschstein, J., Naeije, G., van den Ameele, J., Espuny-Camacho, I., Herpoel, A., Passante, L., Schiffmann, S. N., et al. (2008) · Nature · doi:10.1038/nature07287 · Cited by 641 · see citing works
Self-citationNeural induction, the default model and embryonic stem cells
Muñoz-Sanjuán, I., & Brivanlou, A. H. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn786 · Cited by 635 · see citing works
Human-specific gene <i>ARHGAP11B</i> promotes basal progenitor amplification and neocortex expansion
Florio, M., Albert, M., Taverna, E., Namba, T., Brandl, H., Lewitus, E., Haffner, C., Sykes, A., Wong, F. K., Peters, J., et al. (2015) · Science · doi:10.1126/science.aaa1975 · Cited by 632 · see citing works
A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex
Reillo, I., Romero, C. D. J., García‐Cabezas, M. Á., & Borrell, V. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq238 · Cited by 631 · see citing works
Current Topics in DEVELOPMENTAL BIOLOGY
(2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(23)00061-3 · Cited by 626 · see citing works
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
Shen, Q., Wang, Y., Dimos, J. T., Fasano, C. A., Phoenix, T. N., Lemischka, I. R., Ivanova, N. B., Stifani, S., Morrisey, E. E., & Temple, S. (2006) · Nature Neuroscience · doi:10.1038/nn1694 · Cited by 625 · see citing works
Johnson, M. B., Kawasawa, Y. I., Mason, C. E., Krsnik, Ž., Coppola, G., Bogdanović, D., Geschwind, D. H., Mane, S. M., State, M. W., & Šestan, N. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.027 · Cited by 603 · see citing works
Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
Paşca, S. P., Portmann, T., Voineagu, I., Yazawa, M., Shcheglovitov, A., Paşca, A. M., Cord, B., Palmer, T. D., Chikahisa, S., Nishino, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2576 · Cited by 585 · see citing works
Roles of Pax-genes in developing and adult brain as suggested by expression patterns
Stoykova, A., & Gruss, P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01395.1994 · Cited by 581 · see citing works
Math1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors
Machold, R. P., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.028 · Cited by 575 · see citing works
Neural Stem Cells: Generating and Regenerating the Brain
Gage, F. H., & Temple, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.037 · Cited by 571 · see citing works
Espuny-Camacho, I., Michelsen, K. A., Gall, D., Linaro, D., Hasche, A., Bonnefont, J., Bali, C., Orduz, D., Bilheu, A., Herpoel, A., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.011 · Cited by 568 · see citing works
Self-citationSynaptic dysregulation in a human iPS cell model of mental disorders
Wen, Z., Nguyen, H. N., Guo, Z., Lalli, M. A., Wang, X., Su, Y., Kim, N.-S., Yoon, K.-J., Shin, J., Zhang, C., et al. (2014) · Nature · doi:10.1038/nature13716 · Cited by 549 · see citing works
The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity
DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00029 · Cited by 527 · see citing works
Modeling human cortical development in vitro using induced pluripotent stem cells
Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., Horvath, T. L., & Vaccarino, F. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202944109 · Cited by 526 · see citing works
Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D. L., Arnold, C. M., Chen, Y.-J. J., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.005 · Cited by 513 · see citing works
Clonally Related Cortical Cells Show Several Migration Patterns
Walsh, C. A., & Cepko, C. L. (1988) · Science · doi:10.1126/science.3137660 · Cited by 509 · see citing works
A neuronal morphologic type unique to humans and great apes
Nimchinsky, E. A., Gilissen, E., Allman, J. M., Perl, D. P., Erwin, J. M., & Hof, P. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5268 · Cited by 494 · see citing works
A functionally characterized test set of human induced pluripotent stem cells
Boulting, G. L., Kiskinis, E., Croft, G. F., Amoroso, M. W., Oakley, D. H., Wainger, B. J., Williams, D. J., Kahler, D. J., Yamaki, M., Davidow, L. S., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1783 · Cited by 489 · see citing works
Directed Differentiation of Dopaminergic Neuronal Subtypes from Human Embryonic Stem Cells
Yan, Y., Yang, D., Żarnowska, E. D., Du, Z., Werbel, B., Valliere, C., Pearce, R. A., Thomson, J. A., & Zhang, S. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0365 · Cited by 489 · see citing works
Accelerated Evolution of Conserved Noncoding Sequences in Humans
Prabhakar, S., Noonan, J. P., Pääbo, S., & Rubin, E. M. (2006) · Science · doi:10.1126/science.1130738 · Cited by 481 · see citing works
Pax6 is a human neuroectoderm cell fate determinant
Zhang, X., Huang, C. T., Chen, J., Pankratz, M. T., Xi, J., Li, J., Yang, Y., LaVaute, T. M., Li, X.-J., Ayala, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.017 · Cited by 480 · see citing works
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terao, M., Nishimura, Y. V., Fukuda, A., Fuse, T., Matsuo, N., Sone, M., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.007 · Cited by 479 · see citing works
Cytosystems dynamics in self-organization of tissue architecture
Sasai, Y. (2013) · Nature · doi:10.1038/nature11859 · Cited by 475 · see citing works
Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin
Pera, M. F., Andrade, J., Houssami, S., Reubinoff, B. E., Trounson, A. O., Stanley, E. G., Oostwaard, D. W., & Mummery, C. L. (2004) · Journal of Cell Science · doi:10.1242/jcs.00970 · Cited by 471 · see citing works
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients
Shcheglovitov, A., Shcheglovitova, O., Yazawa, M., Portmann, T., Shu, R., Sebastiano, V., Krawisz, A., Froehlich, W., Bernstein, J. A., Hallmayer, J. F., et al. (2013) · Nature · doi:10.1038/nature12618 · Cited by 470 · see citing works
Betizeau, M., Cortay, V., Patti, D., Pfister, S., Gautier, E., Bellemin-Ménard, A., Afanassieff, M., Huissoud, C., Douglas, R. J., Kennedy, H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.032 · Cited by 462 · see citing works
Early Steps in the Development of the Forebrain
Wilson, S. W., & Houart, C. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00027-9 · Cited by 460 · see citing works
Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation
Charrier, C., Joshi, K., Coutinho-Budd, J., Kim, J.-E., Lambert, N., de Marchena, J., Jin, W.-L., Vanderhaeghen, P., Ghosh, A., Sassa, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.034 · Cited by 454 · see citing works
Self-citationPluripotent stem cells in regenerative medicine: challenges and recent progress
Tabar, V., & Studer, L. (2014) · Nature reviews genetics · doi:10.1038/nrg3563 · Cited by 434 · see citing works
Redefining the Progression of Lineage Segregations during Mammalian Embryogenesis by Clonal Analysis
Tzouanacou, E., Wegener, A., Wymeersch, F. J., Wilson, V. A., & Nicolas, J.-F. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.002 · Cited by 427 · see citing works
Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer
Price, J., & Thurlow, L. (1988) · Development · doi:10.1242/dev.104.3.473 · Cited by 424 · see citing works
Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex
Gao, P., Postiglione, M. P., Krieger, T. G., Hernandez, L., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.027 · Cited by 423 · see citing works
Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6
Chapman, D. L., & Papaioannou, V. E. (1998) · Nature · doi:10.1038/35624 · Cited by 420 · see citing works
Maury, Y., Côme, J., Piskorowski, R. A., Salah‐Mohellibi, N., Chevaleyre, V., Peschanski, M., Martinat, C., & Nedelec, S. (2014) · Nature Biotechnology · doi:10.1038/nbt.3049 · Cited by 410 · see citing works
Intrinsically different retinal progenitor cells produce specific types of progeny
Cepko, C. L. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3767 · Cited by 388 · see citing works
Forebrain patterning defects in Small eye mutant mice
Stoykova, A., Fritsch, R., Walther, C., & Gruß, P. (1996) · Development · doi:10.1242/dev.122.11.3453 · Cited by 378 · see citing works
Gouti, M., Tsakiridis, A., Wymeersch, F. J., Huang, Y., Kleinjung, J., Wilson, V. A., & Briscoe, J. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001937 · Cited by 364 · see citing works
Restriction of Late Cerebral Cortical Progenitors to an Upper-Layer Fate
Frantz, G. D., & McConnell, S. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80280-9 · Cited by 356 · see citing works
Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue
Kuwahara, A., Ozone, C., Nakano, T., Saito, K., Eiraku, M., & Sasai, Y. (2015) · Nature Communications · doi:10.1038/ncomms7286 · Cited by 353 · see citing works
Vallier, L., Reynolds, D. S., & Pedersen, R. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.031 · Cited by 350 · see citing works
Fate-Restricted Neural Progenitors in the Mammalian Cerebral Cortex
Franco, S. J., Gil, C., Martínez‐Garay, I., Espinosa, A., Harkins-Perry, S. R., Ramos, C., & Müller, U. (2012) · Science · doi:10.1126/science.1223616 · Cited by 334 · see citing works
Assigning the Positional Identity of Spinal Motor Neurons
Liu, J.-P., Laufer, E., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00544-x · Cited by 329 · see citing works
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Hansen, D. V., Lui, J. H., Flandin, P., Yoshikawa, K., Rubenstein, J. L., Alvarez-Buylla, A., & Kriegstein, A. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3541 · Cited by 328 · see citing works
G1 Phase Regulation, Area-Specific Cell Cycle Control, and Cytoarchitectonics in the Primate Cortex
Lukaszewicz, A., Savatier, P., Cortay, V., Giroud, P., Huissoud, C., Berland, M., Kennedy, H., & Dehay, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.032 · Cited by 315 · see citing works
Fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation
McConnell, S. K. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00945.1988 · Cited by 314 · see citing works
Induction and Dorsoventral Patterning of the Telencephalon
Wilson, S. W., & Rubenstein, J. L. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00171-9 · Cited by 314 · see citing works
The outer subventricular zone and primate-specific cortical complexification
Dehay, C., Kennedy, H., & Kosik, K. S. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.060 · Cited by 314 · see citing works
The human brain in a dish: The promise of iPSC-derived neurons
Dolmetsch, R., & Geschwind, D. (2011) · Cell · doi:10.1016/j.cell.2011.05.034 · Cited by 313 · see citing works
Li, X.-J., Zhang, X., Johnson, M. A., Wang, Z.-B., LaVaute, T. M., & Zhang, S. (2009) · Development · doi:10.1242/dev.036624 · Cited by 312 · see citing works
Cell fate determination in the vertebrate retina
Bassett, E. A., & Wallace, V. A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.05.004 · Cited by 308 · see citing works
Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
Liu, Y., Liu, H., Sauvey, C., Yao, L., Żarnowska, E. D., & Zhang, S. (2013) · Nature Protocols · doi:10.1038/nprot.2013.106 · Cited by 300 · see citing works
Ma, L., Hu, B., Liu, Y., Vermilyea, S., Liu, H., Gao, L., Sun, Y., Zhang, X., & Zhang, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.021 · Cited by 293 · see citing works
Progressive induction of caudal neural character by graded Wnt signaling
Nordström, U., Jessell, T. M., & Edlund, H. (2002) · Nature Neuroscience · doi:10.1038/nn0602-854 · Cited by 290 · see citing works
Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex
Johnson, M. B., Wang, P. P., Atabay, K. D., Murphy, E. A., Doan, R. N., Hecht, J. L., & Walsh, C. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3980 · Cited by 288 · see citing works
Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells
Takemoto, T., Uchikawa, M., Yoshida, M., et al. (2011) · Nature · doi:10.1038/nature09729 · Cited by 288 · see citing works
Stepwise differentiation of pluripotent stem cells into retinal cells
Osakada, F., Ikeda, H., Sasai, Y., & Takahashi, M. (2009) · Nature Protocols · doi:10.1038/nprot.2009.51 · Cited by 278 · see citing works
Graw, J. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)90010-0 · Cited by 274 · see citing works
Making bigger brains–the evolution of neural-progenitor-cell division
Fish, J. L., Dehay, C., Kennedy, H., & Huttner, W. B. (2008) · Journal of Cell Science · doi:10.1242/jcs.023465 · Cited by 274 · see citing works
Tbx6,a Mouse T-Box Gene Implicated in Paraxial Mesoderm Formation at Gastrulation
Chapman, D. L., Agulnik, I., Hancock, S. P., et al. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0326 · Cited by 262 · see citing works
Zhu, Q., Song, L., Peng, G., Sun, N., Chen, J., Zhang, T., Sheng, N., Tang, W., Qian, C., Qiao, Y., et al. (2014) · eLife · doi:10.7554/elife.02224 · Cited by 249 · see citing works
Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells
Amoroso, M. W., Croft, G. F., Williams, D. J., O’Keeffe, S., Carrasco, M. A., Davis, A. R., Roybon, L., Oakley, D. H., Maniatis, T., Henderson, C. E., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0906-12.2013 · Cited by 248 · see citing works
The Generation Of Neuronal Diversity In The Central Nervous System
McConnell, S. K. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.001413 · Cited by 247 · see citing works
Regulating proliferation during retinal development
Dyer, M. A., & Cepko, C. L. (2001) · Nature reviews. Neuroscience · doi:10.1038/35072555 · Cited by 241 · see citing works
From Progenitors to Differentiated Cells in the Vertebrate Retina
Agathocleous, M., & Harris, W. A. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113259 · Cited by 240 · see citing works
Yoon, K.-J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N.-S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.003 · Cited by 240 · see citing works
Development of the cerebellum: simple steps to make a ‘little brain’
Butts, T., Green, M. J., & Wingate, R. J. T. (2014) · Development · doi:10.1242/dev.106559 · Cited by 239 · see citing works
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences
Smukler, S. R., Runciman, S. B., Xu, S., & van der Kooy, D. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508085 · Cited by 238 · see citing works
Systematic widespread clonal organization in cerebral cortex
Reid, C. B., Llang, I., & Walsh, C. (1995) · Neuron · doi:10.1016/0896-6273(95)90035-7 · Cited by 232 · see citing works
Initial patterning of the central nervous system: How many organizers?
Stern, C. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053563 · Cited by 226 · see citing works
Kelava, I., Reillo, I., Murayama, A. Y., Kalinka, A. T., Stenzel, D., Tomančák, P., Matsuzaki, F., Lebrand, C., Sasaki, E., Schwamborn, J. C., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr301 · Cited by 212 · see citing works
Opportunities and challenges of pluripotent stem cell neurodegenerative disease models
Sandoe, J., & Eggan, K. (2013) · Nature Neuroscience · doi:10.1038/nn.3425 · Cited by 209 · see citing works
Molecular insights into human brain evolution
Hill, R. S., & Walsh, C. A. (2005) · Nature · doi:10.1038/nature04103 · Cited by 208 · see citing works
Cortical area and species differences in dendritic spine morphology
Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R. (2002) · Journal of Neurocytology · doi:10.1023/a:1024134312173 · Cited by 207 · see citing works
van de Leemput, J., Boles, N. C., Kiehl, T. R., Corneo, B., Lederman, P. L., Menon, V., Lee, C., Martinez, R. A., Levi, B. P., Thompson, C. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.013 · Cited by 207 · see citing works
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors
Kamiya, D., Banno, S., Sasai, N., Ohgushi, M., Inomata, H., Watanabe, K., Kawada, M., Yakura, R., Kiyonari, H., Nakao, K., et al. (2011) · Nature · doi:10.1038/nature09726 · Cited by 203 · see citing works
In vitro organogenesis in three dimensions: self-organising stem cells
Sasai, Y., Eiraku, M., & Suga, H. (2012) · Development · doi:10.1242/dev.079590 · Cited by 201 · see citing works
Zeng, H., Guo, M., Martins‐Taylor, K., Wang, X., Zhang, Z., Park, J. W., Zhan, S., Kronenberg, M. S., Lichtler, A. C., Liu, H.-X., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011853 · Cited by 196 · see citing works
Proposal of a model of mammalian neural induction
Levine, A. J., & Brivanlou, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.036 · Cited by 195 · see citing works
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
Studer, L., Vera, E., & Cornacchia, D. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.004 · Cited by 186 · see citing works
Interneurons from Embryonic Development to Cell-Based Therapy
Southwell, D. G., Nicholas, C. R., Basbaum, A. I., Stryker, M. P., Kriegstein, A. R., Rubenstein, J. L. R., & Álvarez-Buylla, A. (2014) · Science · doi:10.1126/science.1240622 · Cited by 185 · see citing works
Cerebellar development and disease
Millen, K. J., & Gleeson, J. G. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.010 · Cited by 184 · see citing works
The first neurons of the human cerebral cortex
Bystron, I., Rakic, P., Molnár, Z., & Blakemore, C. (2006) · Nature Neuroscience · doi:10.1038/nn1726 · Cited by 183 · see citing works
Danjo, T., Eiraku, M., Muguruma, K., Watanabe, K., Kawada, M., Yanagawa, Y., Rubenstein, J. L. R., & Sasai, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5128-10.2011 · Cited by 179 · see citing works
Reillo, I., & Borrell, V. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr284 · Cited by 177 · see citing works
Guo, C., Eckler, M. J., McKenna, W. L., McKinsey, G. L., Rubenstein, J. L. R., & Chen, B. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.037 · Cited by 170 · see citing works
Weinstein, D. C., & Hemmati‐Brivanlou, A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.411 · Cited by 170 · see citing works
Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex
Lui, J. H., Nowakowski, T. J., Pollen, A. A., Javaherian, A., Kriegstein, A. R., & Oldham, M. C. (2014) · Nature · doi:10.1038/nature13973 · Cited by 166 · see citing works
Ontogeny-recapitulating generation and tissue integration of ES cell–derived Purkinje cells
Muguruma, K., Nishiyama, A., Ono, Y., Miyawaki, H., Mizuhara, E., Hori, S., Kakizuka, A., Obata, K., Yanagawa, Y., Hirano, T., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2638 · Cited by 162 · see citing works
Neural induction: 10 years on since the ‘default model’
Stern, C. D. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.09.002 · Cited by 162 · see citing works
Turner, D. A., Hayward, P. C., Baillie‐Johnson, P., Rué, P., Broome, R., Faunes, F., & Arias, A. M. (2014) · Development · doi:10.1242/dev.112979 · Cited by 158 · see citing works
García‐Moreno, F., Vasistha, N. A., Trévia, N., Bourne, J. A., & Molnár, Z. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr312 · Cited by 154 · see citing works
Differentiation of ES cells into cerebellar neurons
Salero, E., & Hatten, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610879104 · Cited by 141 · see citing works
How to make spinal motor neurons
Davis‐Dusenbery, B. N., Williams, L. A., Klim, J. R., & Eggan, K. C. (2014) · Development · doi:10.1242/dev.097410 · Cited by 137 · see citing works
Nordström, U., Maier, E., Jessell, T. M., & Edlund, H. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040252 · Cited by 130 · see citing works
Brown, J. M., & Storey, K. G. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00601-1 · Cited by 129 · see citing works
Chng, Z., Teo, A. K. K., Pedersen, R. A., & Vallier, L. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.11.015 · Cited by 129 · see citing works
Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis
Smith, A. N., Miller, L. D., Radice, G. L., Ashery‐Padan, R., & Lang, R. A. (2009) · Development · doi:10.1242/dev.037341 · Cited by 121 · see citing works
Generation of cerebellar neuron precursors from embryonic stem cells
Su, H., Muguruma, K., Matsuo‐Takasaki, M., Kengaku, M., Watanabe, K., & Sasai, Y. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.010 · Cited by 119 · see citing works
Cellular and molecular basis of cerebellar development
Martı́nez, S., Andreu‐Cervera, A., Mecklenburg, N., & Echevarrı́a, D. (2013) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2013.00018 · Cited by 118 · see citing works
Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation
Hyer, J. D., Kuhlman, J. A., Afif, E., et al. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00205-7 · Cited by 117 · see citing works
Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells
Hansen, D. V., Rubenstein, J. L. R., & Kriegstein, A. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.006 · Cited by 116 · see citing works
Mechanisms of neural specification from embryonic stem cells
Gaspard, N., & Vanderhaeghen, P. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.12.001 · Cited by 115 · see citing works
Self-citationThe route to spinal cord cell types: a tale of signals and switches
Gouti, M., Metzis, V., & Briscoe, J. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.03.001 · Cited by 103 · see citing works
How to make a hippocampal dentate gyrus granule neuron
Yu, D. X., Marchetto, M. C., & Gage, F. H. (2014) · Development · doi:10.1242/dev.096776 · Cited by 103 · see citing works
Induced pluripotent stem cells and reprogramming: seeing the science through the hype
Belmonte, J. C., Ellis, J., Hochedlinger, K., & Yamanaka, S. (2009) · Nature reviews genetics · doi:10.1038/nrg2700 · Cited by 100 · see citing works
Nasu, M., Takata, N., Danjo, T., Sakaguchi, H., Kadoshima, T., Futaki, S., Sekiguchi, K., Eiraku, M., & Sasai, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053024 · Cited by 93 · see citing works
Suzuki, I. K., Kawasaki, T., Gojobori, T., & Hirata, T. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.01.004 · Cited by 92 · see citing works
Self-citationModeling human development in 3D culture
Ader, M., & Tanaka, E. M. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.013 · Cited by 89 · see citing works
Prospective Isolation of Cortical Interneuron Precursors from Mouse Embryonic Stem Cells
Maroof, A. M., Brown, K. N., Shi, S., Studer, L., & Anderson, S. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4255-09.2010 · Cited by 84 · see citing works
Lambert, N., Lambot, M.-A., Bilheu, A., Albert, V., Englert, Y., Libert, F., Noel, J.-C., Sotiriou, C., Holloway, A. K., Pollard, K. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017753 · Cited by 73 · see citing works
Self-citationProgramming embryonic stem cells to neuronal subtypes
Peljto, M., & Wichterle, H. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.09.012 · Cited by 73 · see citing works
Maturation of Spinal Motor Neurons Derived from Human Embryonic Stem Cells
Takazawa, T., Croft, G. F., Amoroso, M. W., Studer, L., Wichterle, H., & MacDermott, A. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040154 · Cited by 72 · see citing works
Martínez‐Morales, J. R., & Wittbrodt, J. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.08.003 · Cited by 72 · see citing works
Primate iPS cells as tools for evolutionary analyses
Wunderlich, S., Kircher, M., Vieth, B., Haase, A., Merkert, S., Beier, J., Göhring, G., Glage, S., Schambach, A., Curnow, E. C., et al. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.02.001 · Cited by 69 · see citing works
Eckler, M. J., Nguyen, T. D., McKenna, W. L., Fastow, B. L., Guo, C., Rubenstein, J. L. R., & Chen, B. (2015) · Neuron · doi:10.1016/j.neuron.2015.04.020 · Cited by 64 · see citing works
Generating Human Neurons In Vitro and Using Them to Understand Neuropsychiatric Disease
Pașca, S. P., Panagiotakos, G., & Dolmetsch, R. E. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170328 · Cited by 64 · see citing works
Efficient Differentiation of Human Embryonic Stem Cells into Functional Cerebellar-Like Cells
Erceg, S., Ronaghi, M., Zipančić, I., Laínez, S., García-Roselló, M., Chen, X., Moreno‐Manzano, V., Rodriguez-Jiménez, F. J., Planells, R., Álvarez‐Dolado, M., et al. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0498 · Cited by 62 · see citing works
iPS cell derived neuronal cells for drug discovery
Heilker, R., Traub, S., Reinhardt, P., Schöler, H. R., & Sterneckert, J. L. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.07.003 · Cited by 60 · see citing works
REPROGRAMMING PATIENT-DERIVED CELLS TO STUDY THE EPILEPIES
Parent, J., & Anderson, S. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3944 · Cited by 58 · see citing works
MiR‐135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF‐β/BMP signaling
Bhinge, A., Poschmann, J., Namboori, S. C., Tian, X., Loh, S. J. H., Traczyk, A., Prabhakar, S., & Stanton, L. W. (2014) · The EMBO Journal · doi:10.1002/embj.201387215 · Cited by 58 · see citing works
Germain, N. D., Banda, E. C., Becker, S., Naegele, J. R., & Grabel, L. B. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0264 · Cited by 57 · see citing works
SMAD7 Directly Converts Human Embryonic Stem Cells to Telencephalic Fate by a Default Mechanism
Ozair, M. Z., Noggle, S., Warmflash, A., Krzyspiak, J., & Brivanlou, A. H. (2012) · Stem Cells · doi:10.1002/stem.1246 · Cited by 43 · see citing works
Suzuki, I., & Hirata, T. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00020 · Cited by 40 · see citing works
Self-citationCortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity
Anderson, S., & Vanderhaeghen, P. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.012 · Cited by 40 · see citing works
Self-citationInduction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid
Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. G., & Nakashima, K. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.09.012 · Cited by 37 · see citing works
Muguruma, K., & Sasai, Y. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2012.01329.x · Cited by 34 · see citing works
Bazin-Lopez, N., Valdivia, L. E., Wilson, S. W., & Gestri, G. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.02.004 · Cited by 34 · see citing works
Suzuki, I., & Hirata, T. (2012) · Development Growth & Differentiation · doi:10.1111/dgd.12020 · Cited by 32 · see citing works
Self-citationThe positional identity of mouse ES cell-generated neurons is affected by BMP signaling
Bertacchi, M., Pandolfini, L., Murenu, E., Viegi, A., Capsoni, S., Cellerino, A., Messina, A., Casarosa, S., & Cremisi, F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1182-3 · Cited by 29 · see citing works
Allodi, I., & Hedlund, E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00109 · Cited by 24 · see citing works
Brain Evolution and Uniqueness in the Human Genome
Amadio, J. P., & Walsh, C. A. (2006) · Cell · doi:10.1016/j.cell.2006.09.007 · Cited by 21 · see citing works
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Espuny-Camacho, I., Arranz, A. M., Fiers, M., Snellinx, A., Ando, K., Munck, S., Bonnefont, J., Lambot, L., Corthout, N., Omodho, L., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.001 · Cited by 244 · see citing works
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Linaro, D., Vermaercke, B., Iwata, R., Ramaswamy, A., Davis, B. A., Boubakar, L., Libé-Philippot, B., Bilheu, A., Bruyne, L. D., Gall, D., et al. (2019) · doi:10.1101/626218 · Cited by 210 · see citing works
“models provide new opportunities to study human neural development (Astick and Vanderhaeghen, 2018; Di Lullo and Kriegstein, 2017; Gaspard and Vanderhaeghen, 2010; Suzuki and Vanderhaeghen, 2015; Zeltner and Studer, 2015).”
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Self-citation
- Authors
- Suzuki, I. K., & Vanderhaeghen, P.
- Affiliations
- Université Libre de Bruxelles (BE)
- Corresponding author
- Vanderhaeghen, Pierre
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-09-15
- Volume
- 142
- Issue
- 18
- Pages
- 3138-3150
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1911595652
- Cited by
- 110
- References
- 180
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 15 · 2020: 15 · 2019: 17 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Development (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Lirias (submittedVersion)
- Funders
- Waalse Gewest
- AXA Research Fund
- Walloon excellence in life sciences and biotechnology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- human brain development, pluripotent stem cells, brain evolution, disease modeling, cell replacement therapy, neuronal differentiation
- MeSH terms
- Brain, Embryonic Induction, Biological Evolution, Humans, Models, Neurological, Retina, Species Specificity, Neurites, Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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