Thinking out of the dish: what to learn about cortical development using pluripotent stem cells

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620 · see citing works

Specification of Cerebral Cortical Areas

Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · see citing works

The Glial Nature of Embryonic and Adult Neural Stem Cells

Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works

Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229 · see citing works

The cell biology of neurogenesis

Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130 · see citing works

Self-organizing optic-cup morphogenesis in three-dimensional culture

Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) · Nature · doi:10.1038/nature09941 · Cited by 2,001 · see citing works

The mechanisms of Hedgehog signalling and its roles in development and disease

Briscoe, J., & Thérond, P. P. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3598 · Cited by 1,751 · see citing works

Neuronal subtype specification in the cerebral cortex

Molyneaux, B. J., Arlotta, P., Menezes, J. R. L., & Macklis, J. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2151 · Cited by 1,632 · see citing works

Evolution of the neocortex: a perspective from developmental biology

Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565 · see citing works

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504 · see citing works

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P., & Kostović, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105108108 · Cited by 1,411 · see citing works

Neurogenic radial glia in the outer subventricular zone of human neocortex

Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works

Modelling schizophrenia using human induced pluripotent stem cells

Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375 · see citing works

Development and Evolution of the Human Neocortex

Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works

Embryo-Derived Stem Cells: Of Mice and Men

Smith, A. G. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.435 · Cited by 1,263 · see citing works

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Israel, M. A., Yuan, S. H., Bardy, C., Reyna, S. M., Mu, Y., Herrera, C., Hefferan, M. P., Van Gorp, S., Nazor, K. L., Boscolo, F. S., et al. (2012) · Nature · doi:10.1038/nature10821 · Cited by 1,253 · see citing works

A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution

Rakic, P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93934-p · Cited by 1,047 · see citing works

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999 · see citing works

The origin and specification of cortical interneurons

Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works

Development of the human cerebral cortex: Boulder Committee revisited

Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977 · see citing works

Molecular logic of neocortical projection neuron specification, development and diversity

Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863 · see citing works

New insights into the classification and nomenclature of cortical GABAergic interneurons

DeFelipe, J., López-Cruz, P. L., Benavides-Piccione, R., Bielza, C., Larrañaga, P., Anderson, S., Burkhalter, A., Cauli, B., Fairén, A., Feldmeyer, D., et al. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3444 · Cited by 833 · see citing works

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830 · see citing works

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. C., & Livesey, F. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3041 · Cited by 813 · see citing works

Directed differentiation of telencephalic precursors from embryonic stem cells

Watanabe, K., Kamiya, D., Nishiyama, A., Katayama, T., Nozaki, S., Kawasaki, H., Watanabe, Y., Mizuseki, K., & Sasai, Y. (2005) · Nature Neuroscience · doi:10.1038/nn1402 · Cited by 784 · see citing works

Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777 · see citing works

Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells

Miyata, T., Kawaguchi, A., Saito, K., Kawano, M., Muto, T., & Ogawa, M. (2004) · Development · doi:10.1242/dev.01173 · Cited by 769 · see citing works

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.009 · Cited by 741 · see citing works

Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion

Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2008 · Cited by 738 · see citing works

Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells

Yamanaka, S. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.012 · Cited by 737 · see citing works

Patterning and plasticity of the cerebral cortex

Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677 · see citing works

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

Kirkeby, A., Grealish, S., Wolf, D. A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O., & Parmar, M. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.009 · Cited by 662 · see citing works

Cell-cycle control and cortical development

Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655 · see citing works

An intrinsic mechanism of corticogenesis from embryonic stem cells

Gaspard, N., Bouschet, T., Hourez, R., Dimidschstein, J., Naeije, G., van den Ameele, J., Espuny-Camacho, I., Herpoel, A., Passante, L., Schiffmann, S. N., et al. (2008) · Nature · doi:10.1038/nature07287 · Cited by 641 · see citing works

The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells

Shen, Q., Wang, Y., Dimos, J. T., Fasano, C. A., Phoenix, T. N., Lemischka, I. R., Ivanova, N. B., Stifani, S., Morrisey, E. E., & Temple, S. (2006) · Nature Neuroscience · doi:10.1038/nn1694 · Cited by 625 · see citing works

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H., & Suzuki, N. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr394 · Cited by 599 · see citing works

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

Paşca, S. P., Portmann, T., Voineagu, I., Yazawa, M., Shcheglovitov, A., Paşca, A. M., Cord, B., Palmer, T. D., Chikahisa, S., Nishino, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2576 · Cited by 585 · see citing works

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

Espuny-Camacho, I., Michelsen, K. A., Gall, D., Linaro, D., Hasche, A., Bonnefont, J., Bali, C., Orduz, D., Bilheu, A., Herpoel, A., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.011 · Cited by 568 · see citing works

The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity

DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00029 · Cited by 527 · see citing works

Modeling human cortical development in vitro using induced pluripotent stem cells

Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., Horvath, T. L., & Vaccarino, F. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202944109 · Cited by 526 · see citing works

Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development

Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D. L., Arnold, C. M., Chen, Y.-J. J., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.005 · Cited by 513 · see citing works

Cytosystems dynamics in self-organization of tissue architecture

Sasai, Y. (2013) · Nature · doi:10.1038/nature11859 · Cited by 475 · see citing works

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

Shcheglovitov, A., Shcheglovitova, O., Yazawa, M., Portmann, T., Shu, R., Sebastiano, V., Krawisz, A., Froehlich, W., Bernstein, J. A., Hallmayer, J. F., et al. (2013) · Nature · doi:10.1038/nature12618 · Cited by 470 · see citing works

Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate

Betizeau, M., Cortay, V., Patti, D., Pfister, S., Gautier, E., Bellemin-Ménard, A., Afanassieff, M., Huissoud, C., Douglas, R. J., Kennedy, H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.032 · Cited by 462 · see citing works

Early Steps in the Development of the Forebrain

Wilson, S. W., & Houart, C. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00027-9 · Cited by 460 · see citing works

The determination of projection neuron identity in the developing cerebral cortex

Leone, D. P., Srinivasan, K., Chen, B., Alcamo, E., & McConnell, S. K. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.006 · Cited by 382 · see citing works

The genetics of early telencephalon patterning: some assembly required

Hébert, J. M., & Fishell, G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2463 · Cited by 377 · see citing works

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

Hansen, D. V., Lui, J. H., Flandin, P., Yoshikawa, K., Rubenstein, J. L., Alvarez-Buylla, A., & Kriegstein, A. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3541 · Cited by 328 · see citing works

Subcortical origins of human and monkey neocortical interneurons

Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3536 · Cited by 322 · see citing works

G1 Phase Regulation, Area-Specific Cell Cycle Control, and Cytoarchitectonics in the Primate Cortex

Lukaszewicz, A., Savatier, P., Cortay, V., Giroud, P., Huissoud, C., Berland, M., Kennedy, H., & Dehay, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.032 · Cited by 315 · see citing works

The human brain in a dish: The promise of iPSC-derived neurons

Dolmetsch, R., & Geschwind, D. (2011) · Cell · doi:10.1016/j.cell.2011.05.034 · Cited by 313 · see citing works

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

Li, X.-J., Zhang, X., Johnson, M. A., Wang, Z.-B., LaVaute, T. M., & Zhang, S. (2009) · Development · doi:10.1242/dev.036624 · Cited by 312 · see citing works

A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

Shi, Y., Kirwan, P., Smith, J., MacLean, G., Orkin, S. H., & Livesey, F. J. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003771 · Cited by 310 · see citing works

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Li, Y., Wang, H., Muffat, J., Cheng, A. W., Orlando, D. A., Lovén, J., Kwok, S., Feldman, D., Bateup, H. S., Gao, Q., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.001 · Cited by 305 · see citing works

Human Embryonic Stem Cell-Derived GABA Neurons Correct Locomotion Deficits in Quinolinic Acid-Lesioned Mice

Ma, L., Hu, B., Liu, Y., Vermilyea, S., Liu, H., Gao, L., Sun, Y., Zhang, X., & Zhang, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.021 · Cited by 293 · see citing works

Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits

Liu, Y., Weick, J. P., Liu, H., Krencik, R., Zhang, X., Ma, L., Zhou, G., Ayala, M., & Zhang, S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2565 · Cited by 276 · see citing works

Making bigger brains–the evolution of neural-progenitor-cell division

Fish, J. L., Dehay, C., Kennedy, H., & Huttner, W. B. (2008) · Journal of Cell Science · doi:10.1242/jcs.023465 · Cited by 274 · see citing works

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

Lizarraga, S. B., Margossian, S. P., Harris, M. H., Campagna, D. R., Han, A., Blevins, S., Mudbhary, R., Barker, J. E., Walsh, C. A., & Fleming, M. D. (2010) · Development · doi:10.1242/dev.040410 · Cited by 270 · see citing works

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

Wataya, T., Ando, S., Muguruma, K., Ikeda, H. O., Watanabe, K., Eiraku, M., Kawada, M., Takahashi, J. B., Hashimoto, N., & Sasai, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803078105 · Cited by 269 · see citing works

Cortical progenitor expansion, self-renewal and neurogenesis—a polarized perspective

Fietz, S. A., & Huttner, W. Β. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.10.002 · Cited by 267 · see citing works

Radial glial cell heterogeneity—The source of diverse progeny in the CNS

Pinto, L., & GOTZ, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.02.010 · Cited by 259 · see citing works

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

Krey, J. F., Pașca, S. P., Shcheglovitov, A., Yazawa, M., Schwemberger, R., Rasmusson, R. L., & Dolmetsch, R. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3307 · Cited by 252 · see citing works

Cell fate specification in the mammalian telencephalon

Guillemot, F. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.02.009 · Cited by 243 · see citing works

Cell types to order: temporal specification of CNS stem cells

Okano, H., & Temple, S. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.04.003 · Cited by 240 · see citing works

Genetic regulation of arealization of the neocortex

O’Leary, D. D. M., & Sahara, S. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.011 · Cited by 219 · see citing works

Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix jacchus

Kelava, I., Reillo, I., Murayama, A. Y., Kalinka, A. T., Stenzel, D., Tomančák, P., Matsuzaki, F., Lebrand, C., Sasaki, E., Schwamborn, J. C., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr301 · Cited by 212 · see citing works

Deficits in human trisomy 21 iPSCs and neurons

Weick, J. P., Held, D. L., Bonadurer, G. F., Doers, M. E., Liu, Y., Maguire, C., Clark, A., Knackert, J. A., Molinarolo, K., Musser, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216575110 · Cited by 205 · see citing works

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

Sandoe, J., & Eggan, K. C. (2013) · Nature Neuroscience · doi:10.1038/nn.3425 · Cited by 192 · see citing works

The first neurons of the human cerebral cortex

Bystron, I., Rakic, P., Molnár, Z., & Blakemore, C. (2006) · Nature Neuroscience · doi:10.1038/nn1726 · Cited by 183 · see citing works

Subregional Specification of Embryonic Stem Cell-Derived Ventral Telencephalic Tissues by Timed and Combinatory Treatment with Extrinsic Signals

Danjo, T., Eiraku, M., Muguruma, K., Watanabe, K., Kawada, M., Yanagawa, Y., Rubenstein, J. L. R., & Sasai, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5128-10.2011 · Cited by 179 · see citing works

Cdk5rap2 Interacts with Pericentrin to Maintain the Neural Progenitor Pool in the Developing Neocortex

Buchman, J. J., Tseng, H.-C., Zhou, Y., Frank, C. L., Xie, Z., & Tsai, L. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.036 · Cited by 177 · see citing works

Germinal Zones in the Developing Cerebral Cortex of Ferret: Ontogeny, Cell Cycle Kinetics, and Diversity of Progenitors

Reillo, I., & Borrell, V. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr284 · Cited by 177 · see citing works

Compartmentalization of Cerebral Cortical Germinal Zones in a Lissencephalic Primate and Gyrencephalic Rodent

García‐Moreno, F., Vasistha, N. A., Trévia, N., Bourne, J. A., & Molnár, Z. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr312 · Cited by 154 · see citing works

Signaling defects in iPSC-derived fragile X premutation neurons

Liu, J., Koscielska, K. A., Cao, Z., Hulsizer, S., Grace, N., Mitchell, G., Nacey, C., Githinji, J., McGee, J., Garcia-Arocena, D., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds207 · Cited by 144 · see citing works

Generation of cortical neurons from mouse embryonic stem cells

Gaspard, N., Bouschet, T., Herpoel, A., Naeije, G., van den Ameele, J., & Vanderhaeghen, P. (2009) · Nature Protocols · doi:10.1038/nprot.2009.157 · Cited by 142 · see citing works

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

Tiberi, L., van den Ameele, J., Dimidschstein, J., Piccirilli, J., Gall, D., Herpoel, A., Bilheu, A., Bonnefont, J., Iacovino, M., Kyba, M., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3264 · Cited by 129 · see citing works

Mechanisms of neural specification from embryonic stem cells

Gaspard, N., & Vanderhaeghen, P. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.12.001 · Cited by 115 · see citing works

Cortical neurogenesis and morphogens: diversity of cues, sources and functions

Tiberi, L., Vanderhaeghen, P., & van den Ameele, J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.01.010 · Cited by 103 · see citing works

Prospective Isolation of Cortical Interneuron Precursors from Mouse Embryonic Stem Cells

Maroof, A. M., Brown, K. N., Shi, S., Studer, L., & Anderson, S. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4255-09.2010 · Cited by 84 · see citing works

Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors

Cambray, S., Arber, C., Little, G. E., Dougalis, A., Paola, V. D., Ungless, M. A., Li, M. C., & Rodríguez, T. A. (2012) · Nature Communications · doi:10.1038/ncomms1817 · Cited by 69 · see citing works

Derivation and Isolation of NKX2.1-Positive Basal Forebrain Progenitors from Human Embryonic Stem Cells

Germain, N. D., Banda, E. C., Becker, S., Naegele, J. R., & Grabel, L. B. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0264 · Cited by 57 · see citing works

From stem cells to neural networks: recent advances and perspectives for neurodevelopmental disorders

Gaspard, N., & Vanderhaeghen, P. (2010) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2010.03827.x · Cited by 54 · see citing works

The best of times, the worst of times for psychiatric disease

the Genetic and Neural Complexity in Psychiatry 2011 Working Group, Karayiorgou, M., Jonathan Flint, C., Gogos, J. A., & Malenka, R. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3115 · Cited by 45 · see citing works

Early Commitment of Embryonic Neocortical Cells to Develop Area-specific Thalamic Connections

Gaillard, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.5.443 · Cited by 38 · see citing works

Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid

Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. G., & Nakashima, K. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.09.012 · Cited by 37 · see citing works

Laminar fate specification in the cerebral cortex

Gaspard, N., & Vanderhaeghen, P. (2011) · F1000 Biology Reports · doi:10.3410/b3-6 · Cited by 36 · see citing works

The positional identity of mouse ES cell-generated neurons is affected by BMP signaling

Bertacchi, M., Pandolfini, L., Murenu, E., Viegi, A., Capsoni, S., Cellerino, A., Messina, A., Casarosa, S., & Cremisi, F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1182-3 · Cited by 29 · see citing works

Stage of specification of the spinal cord and tectal projections from cortical grafts

Pinaudeau-Nasarre, C., Gaillard, A., & Roger, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00148.x · Cited by 22 · see citing works

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M., & Sestan, N. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.008 · Cited by 818 · see citing works

Altering the course of schizophrenia: progress and perspectives

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.28 · Cited by 516 · see citing works

Species-specific developmental timing is associated with differences in protein stability in mouse and human

Rayon, T., Stamataki, D., Pérez-Carrasco, R., Garcia-Perez, L., Barrington, C., Melchionda, M., Exelby, K., Lázaro, J., Tybulewicz, V., Fisher, E., et al. (2020) · Science · doi:10.1126/science.aba7667 · Cited by 230 · see citing works

Species-specific segmentation clock periods are due to differential biochemical reaction speeds

Matsuda, M., Hayashi, H., Garcia-Ojalvo, J., Yoshioka-Kobayashi, K., Kageyama, R., Yamanaka, Y., Ikeya, M., Toguchida, J., Alev, C., & Ebisuya, M. (2020) · Science · doi:10.1126/science.aba7668 · Cited by 254 · see citing works

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

Espuny-Camacho, I., Arranz, A. M., Fiers, M., Snellinx, A., Ando, K., Munck, S., Bonnefont, J., Lambot, L., Corthout, N., Omodho, L., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.001 · Cited by 244 · see citing works

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits

Linaro, D., Vermaercke, B., Iwata, R., Ramaswamy, A., Davis, B. A., Boubakar, L., Libé-Philippot, B., Bilheu, A., Bruyne, L. D., Gall, D., et al. (2019) · doi:10.1101/626218 · Cited by 210 · see citing works

Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells

Michelsen, K. A., Acosta-Verdugo, S., Benoit-Marand, M., Espuny-Camacho, I., Gaspard, N., Saha, B., Gaillard, A., & Vanderhaeghen, P. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.001 · Cited by 138 · see citing works

From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks

Bosi, S., Rauti, R., Laishram, J., Turco, A., Lonardoni, D., Nieus, T. R., Prato, M., Scaini, D., & Ballerini, L. (2015) · Scientific Reports · doi:10.1038/srep09562 · Cited by 139 · see citing works

What does time mean in development?

Ebisuya, M., & Briscoe, J. (2018) · Development · doi:10.1242/dev.164368 · Cited by 136 · see citing works

In vivo modeling of human neuron dynamics and Down syndrome

Real, R., Peter, M., Trabalza, A., Khan, S., Smith, M. A., Dopp, J., Barnes, S. J., Momoh, A., Strano, A., Volpi, E., et al. (2018) · Science · doi:10.1126/science.aau1810 · Cited by 120 · see citing works

Effects of antenatal glucocorticoids on the developing brain

Carson, R. A., Monaghan, A. P., DeFranco, D. B., & Rudine, A. C. (2016) · Steroids · doi:10.1016/j.steroids.2016.05.012 · Cited by 106 · see citing works

Neuronal and glial regulation of CNS angiogenesis and barriergenesis

Biswas, S., Cottarelli, A., & Agalliu, D. (2020) · Development · doi:10.1242/dev.182279 · Cited by 107 · see citing works

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way

Espuny-Camacho, I., Michelsen, K. A., Linaro, D., Bilheu, A., Acosta-Verdugo, S., Herpoel, A., Giugliano, M., Gaillard, A., & Vanderhaeghen, P. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.094 · Cited by 88 · see citing works

Human neuronal maturation comes of age: cellular mechanisms and species differences

Wallace, J. L., & Pollen, A. A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00760-3 · Cited by 82 · see citing works

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G., Zhou, Y., & Li, Y. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0423 · Cited by 80 · see citing works

Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution

Libé-Philippot, B., & Vanderhaeghen, P. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071719-020705 · Cited by 78 · see citing works

Generating human neural diversity with a multiplexed morphogen screen in organoids

Amin, N. D., Kelley, K. W., Kaganovsky, K., Onesto, M. M., Hao, J., Miura, Y., McQueen, J. P., Reis, N., Narazaki, G., Li, T., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.10.016 · Cited by 70 · see citing works

Timing temporal transitions during brain development

Rossi, A., Fernandes, V. M., & Desplan, C. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.010 · Cited by 74 · see citing works

Utilizing stem cells for three-dimensional neural tissue engineering

Knowlton, S. M., Cho, Y. K., Li, X. J., Khademhosseini, A., & Taşoğlu, S. (2016) · Biomaterials Science · doi:10.1039/c5bm00324e · Cited by 69 · see citing works

The multifaceted roles of primary cilia in the development of the cerebral cortex

Hasenpusch-Theil, K., & Theil, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.630161 · Cited by 66 · see citing works

Bioscaffold-Induced Brain Tissue Regeneration

Modo, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01156 · Cited by 63 · see citing works

Derivation and Isolation of NKX2.1-Positive Basal Forebrain Progenitors from Human Embryonic Stem Cells

Germain, N. D., Banda, E. C., Becker, S., Naegele, J. R., & Grabel, L. B. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0264 · Cited by 57 · see citing works

Superstructured Biomaterials Formed by Exchange Dynamics and Host–Guest Interactions in Supramolecular Polymers

Edelbrock, A. N., Clemons, T. D., Chin, S. M., Roan, J. J. W., Bruckner, E. P., Álvarez, Z., Edelbrock, J. F., Wek, K. S., & Stupp, S. I. (2021) · Advanced Science · doi:10.1002/advs.202004042 · Cited by 53 · see citing works

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

Heurck, R. V., Bonnefont, J., Wojno, M., Suzuki, I., Velez-Bravo, F. D., Erkol, E., Nguyen, D. T., Herpoel, A., Bilheu, A., Beckers, S., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.018 · Cited by 51 · see citing works

Neural Stem Cells and Fetal-Onset Hydrocephalus

Rodríguez, E. M., & Guerra, M. M. (2017) · Pediatric Neurosurgery · doi:10.1159/000453074 · Cited by 47 · see citing works

Neural patterning of human induced pluripotent stem cells in 3-D cultures for studying biomolecule-directed differential cellular responses

Yan, Y., Bejoy, J., Xia, J., Guan, J., Zhou, Y., & Li, Y. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.06.027 · Cited by 45 · see citing works

Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids

Bu, Q., Huang, Y., Li, M., Dai, Y., Fang, X. H., Chen, K., Liu, Q., Xue, A., Zhong, K., Huang, Y., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111643 · Cited by 44 · see citing works

Derivation of Cortical Spheroids from Human Induced Pluripotent Stem Cells in a Suspension Bioreactor

Yan, Y., Song, L., Madinya, J. J., Ma, T., & Li, Y. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0400 · Cited by 41 · see citing works

Human neural organoids: Models for developmental neurobiology and disease

Guy, B., Zhang, J. S., Duncan, L. H., & Johnston, R. J. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.06.012 · Cited by 41 · see citing works

Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome

Parkes, L., Kim, J. Z., Stiso, J., Calkins, M. E., Cieslak, M., Gur, R. E., Gur, R. C., Moore, T. M., Ouellet, M., Roalf, D. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.add2185 · Cited by 34 · see citing works

Implications of Extended Inhibitory Neuron Development

Kim, J.-Y., & Paredes, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105113 · Cited by 35 · see citing works

Cellular Basis of Cognition in Evolution: From Protists and Fungi Up to Animals, Plants, and Root-Fungal Networks

Baluška, F., Miller, W. B., & Reber, A. S. (2023) · The MIT Press eBooks · doi:10.7551/mitpress/14642.003.0006 · Cited by 33 · see citing works

Metabolic mechanisms of species-specific developmental tempo

Iwata, R., & Vanderhaeghen, P. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.027 · Cited by 32 · see citing works

Wnt/Yes-Associated Protein Interactions During Neural Tissue Patterning of Human Induced Pluripotent Stem Cells

Bejoy, J., Song, L., Zhou, Y., & Li, Y. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0153 · Cited by 32 · see citing works

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient‐specific neural cells

Fernandes, T. G., Duarte, S. T., Ghazvini, M., Gaspar, C., Santos, D. C., Porteira, A. R., Rodrigues, G., Haupt, S., Rombo, D. M., Armstrong, J., et al. (2015) · Biotechnology Journal · doi:10.1002/biot.201400751 · Cited by 29 · see citing works

Human brain development and its in vitro recapitulation

Seto, Y., & Eiraku, M. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.09.011 · Cited by 26 · see citing works

The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration

Schoof, M., Launspach, M., Holdhof, D., Nguyen, L., Engel, V., Filser, S., Peters, F., Immenschuh, J., Hellwig, M., Niesen, J., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0849-5 · Cited by 25 · see citing works

Human Embryonic Stem Cell Therapy in Cerebral Palsy Children with Cortical Visual Impairment: A Case Series of 40 Patients

Das, G. S. L. (2014) · Journal of Cell Science & Therapy · doi:10.4172/2157-7013.1000189 · Cited by 25 · see citing works

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells

Livesey, M. R., Magnani, D., Hardingham, G. E., Chandran, S., & Wyllie, D. J. A. (2015) · The Journal of Physiology · doi:10.1113/jp270660 · Cited by 24 · see citing works

Using mouse transgenic and human stem cell technologies to model genetic mutations associated with schizophrenia and autism

Clair, D. S., & Johnstone, M. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0037 · Cited by 24 · see citing works

Development of the Nervous System

Yuskaitis, C. J., & Pomeroy, S. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00131-1 · Cited by 24 · see citing works

532 nm Low-Power Laser Irradiation Facilitates the Migration of GABAergic Neural Stem/Progenitor Cells in Mouse Neocortex

Fukuzaki, Y., Shin, H., Kawai, H. D., Yamanoha, B., & Kogure, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123833 · Cited by 21 · see citing works

Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models

Magni, M., Bossi, B., Conforti, P., Galimberti, M., Dezi, F., Lischetti, T., He, X., Barker, R., Zuccato, C., Espuny-Camacho, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113159 · Cited by 21 · see citing works

Glutaminolysis and the Control of Neural Progenitors in Neocortical Development and Evolution

Gkini, V., & Namba, T. (2022) · The Neuroscientist · doi:10.1177/10738584211069060 · Cited by 17 · see citing works

Early development of the cochlea of the common marmoset, a non-human primate model

Hosoya, M., Fujioka, M., Okahara, J., Yoshimatsu, S., Okano, H., & Ozawa, H. (2022) · Neural Development · doi:10.1186/s13064-022-00162-8 · Cited by 17 · see citing works

Primate neocortex development and evolution: Conserved versus evolved folding

Namba, T., Vaid, S., & Huttner, W. Β. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24606 · Cited by 16 · see citing works

Exploring the Complexity of Cortical Development Using Single-Cell Transcriptomics

Jeong, H., & Tiwari, V. K. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00031 · Cited by 16 · see citing works

Temporal differences of neurodevelopment processes between species

Iwata, R. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.08.004 · Cited by 14 · see citing works

Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers

Miskinyte, G., Hansen, M. G., Monni, E., Lam, M., Bengzon, J., Lindvall, O., Ahlenius, H., & Kokaia, Z. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204688 · Cited by 16 · see citing works

Efficient Generation of Corticofugal Projection Neurons from Human Embryonic Stem Cells

Zhu, X., Ai, Z., Hu, X., & Li, T. (2016) · Scientific Reports · doi:10.1038/srep28572 · Cited by 16 · see citing works

The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation

Terrigno, M., Bertacchi, M., Pandolfini, L., Baumgart, M., Calvello, M., Cellerino, A., Studer, M., & Cremisi, F. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.08.002 · Cited by 15 · see citing works

Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development

Graffunder, A. S., Bresser, A. A. J., Vallone, V. B. F., Megges, M., Stachelscheid, H., Kühnen, P., & Opitz, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-59533-2 · Cited by 16 · see citing works

Finding degrees of separation: Experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting

Chew, L., DeBoy, C. A., & Senatorov, V. V. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.08.017 · Cited by 13 · see citing works

Pluripotent Stem Cells for Brain Repair: Protocols and Preclinical Applications in Cortical and Hippocampal Pathologies

Alia, C., Terrigno, M., Busti, I., Cremisi, F., & Caleo, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00684 · Cited by 14 · see citing works

Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey

Ramirez, C. G., Salvador, S. G., Patel, R. K. R., Clark, S., Miller, N. W., James, L. M., Ringelberg, N. W., Simon, J. M., Bennett, J., Amaral, D. G., et al. (2024) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2024.1410791 · Cited by 14 · see citing works

A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction

Bansal, P., Banda, E. C., Glatt-Deeley, H. R., Stoddard, C. E., Linsley, J. W., Arora, N., Deleschaux, C., Ahern, D. T., Kondaveeti, Y., Massey, R. E., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj0385 · Cited by 13 · see citing works

Cloning, gene regulation, and neuronal proliferation functions of novel N‐terminal–truncated carboxypeptidase E/neurotrophic factor‐αl variants in embryonic mouse brain

Xiao, L., Yang, X.-Y., Sharma, V., & Loh, Y. P. (2018) · The FASEB Journal · doi:10.1096/fj.201800359r · Cited by 13 · see citing works

PAX6 does not regulate Nfia and Nfib expression during neocortical development

Bunt, J., Lim, J. W. C., Zhao, L., Mason, S., & Richards, L. J. (2015) · Scientific Reports · doi:10.1038/srep10668 · Cited by 13 · see citing works

Murine pluripotent stem cells with a homozygous knockout of Foxg1 show reduced differentiation towards cortical progenitors in vitro

Mall, E. M., Herrmann, D., & Niemann, H. (2017) · Stem Cell Research · doi:10.1016/j.scr.2017.10.012 · Cited by 12 · see citing works

Scalable control of developmental timetables by epigenetic switching networks

Nguyen, P., Pease, N. A., & Kueh, H. Y. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0109 · Cited by 11 · see citing works

Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene

Kostic, M., Raymond, J. J., Freyre, C. A. C., Henry, B., Tumkaya, T., Khlghatyan, J., Dvornik, J., Li, J., Hsiao, J. S., Cheon, S. H., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00442 · Cited by 12 · see citing works

Neural Tube Organoids: A Novel System to Study Developmental Timing

Rabeling, A., van der Hoven, A., Andersen, N., & Goolam, M. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10785-5 · Cited by 9 · see citing works

Ventral Telencephalic Patterning Protocols for Induced Pluripotent Stem Cells

Krajka, V., Naujock, M., Pauly, M. G., Stengel, F. C., Meier, B., Stanslowsky, N., Klein, C., Seibler, P., Wegner, F., & Capetian, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716249 · Cited by 9 · see citing works

Nanotechnology Facilitated Cultured Neuronal Network and Its Applications

Singh, S., Mishra, S., Song, J., Pramanik, M., Padmanabhan, P., & Gulyás, B. Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115552 · Cited by 8 · see citing works

Deriving Neural Cells from Pluripotent Stem Cells for Nanotoxicity Testing

Hong, Y., Chan, N., & Begum, A. N. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8916-4_4 · Cited by 8 · see citing works

Tempus fugit: How time flies during development

Iwata, R., & Vanderhaeghen, P. (2020) · Science · doi:10.1126/science.abe0953 · Cited by 8 · see citing works

Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

Wei, N., Quan, Z.-F., Tang, H., & Zhu, J. (2017) · Stem Cells International · doi:10.1155/2017/5682354 · Cited by 7 · see citing works

Learning about cell lineage, cellular diversity and evolution of the human brain through stem cell models

Bail, R. L., Bonafina, A., Espuny-Camacho, I., & Nguyen, L. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.018 · Cited by 6 · see citing works

Ultrasound Used for Diagnostic Imaging Facilitates Dendritic Branching of Developing Neurons in the Mouse Cortex

Papp, T., Ferenczi, Z., Szilagyi, B., Petró, M., Varga, A., Kókai, É., Berényi, E. L., Oláh, G., Halmos, G., Szűcs, P., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.803356 · Cited by 6 · see citing works

Examining the NEUROG2 lineage and associated gene expression in human cortical organoids

Vasan, L., Chinchalongporn, V., Saleh, F., Zinyk, D. L., Ke, C., Suresh, H., Ghazale, H., Belfiore, L., Touahri, Y., Oproescu, A.-M., et al. (2024) · Development · doi:10.1242/dev.202703 · Cited by 6 · see citing works

Organoids as tools for fundamental discovery and translation—a Keystone Symposia report

Cable, J., Lütolf, M. P., Fu, J., Park, S. E., Apostolou, A. P., Chen, S., Song, C. J., Spence, J. R., Liberali, P., Lancaster, M. A., et al. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14874 · Cited by 6 · see citing works

Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells

Ihnatovych, I., Lew, A. R., Lazar, E. B., Sheng, A., Kellermayer, T. R., & Szigeti, K. (2018) · Stem Cells International · doi:10.1155/2018/3983090 · Cited by 6 · see citing works

Multi-omic analysis of the ciliogenic transcription factor RFX3 reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neuronsPreprint

Lai, J. F., Demirbas, D., Phillips, K., Zhao, B., Wallace, H., Seferian, M., Nakayama, T., Harris, H. K., Chatzipli, A., Lee, E. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.27.640588 · Cited by 6 · see citing works

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

Cesari, E., Farini, D., Medici, V., Ehrmann, I. E., Guerra, M., Testa, E., Naro, C., Geloso, M. C., Pagliarini, V., Barbera, L. L., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae071 · Cited by 5 · see citing works

Stem Cells to Inform the Neurobiology of Mental Illness

Johnstone, M., Hillary, R. F., & Clair, D. S. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_57 · Cited by 5 · see citing works

Dynamic Changes of Mouse Embryonic Stem Cell-Derived Neural Stem Cells Under In Vitro Prolonged Culture and Hypoxic Conditions

Lukmanto, D., Khánh, V. C., Shirota, S., Kato, T., Takasaki, M. M., & Ohneda, O. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0101 · Cited by 5 · see citing works

Bioengineering of the Human Neural Stem Cell Niche: A Regulatory Environment for Cell Fate and Potential Target for Neurotoxicity

Bużańska, L., Zychowicz, M., & Kinsner‐Ovaskainen, A. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-93485-3_9 · Cited by 5 · see citing works

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineagesPreprint

Rowton, M., Perez-Cervantes, C., Rydeen, A. B., Hur, S. S. J., Jacobs-Li, J., Deng, N., Lu, E., Guzzetta, A., Steimle, J. D., Hoffmann, A. D., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/270751 · Cited by 5 · see citing works

Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders

Verma, I., & Seshagiri, P. B. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10851-6 · Cited by 4 · see citing works

Top ten discoveries of the year: Neurodevelopmental disorders

Dierssen, M. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-2672 · Cited by 4 · see citing works

Repeated diagnostic ultrasound exposure modifies the structural properties of CA1 dendrites and alters the hippocampal transcriptome

Ferenczi, Z., Pelyvas, B., Nagy, M., Marosi, M., Béresová, M., Varga, R., Bencze, J., Szűcs, P., Berényi, E. L., Angelika, E., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-62621-y · Cited by 3 · see citing works

Functional landscape of non-canonical open reading frames in coordinating cell fate

Zhu, K., Li, W.-C., Liu, J., Yang, B. A., Guzman, E., Guzman, M., Sit, R. V., Yan, J., Granat, A., Chen, S.-A. A., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.02.010 · Cited by 3 · see citing works

Humanized Chimeric Mouse Models to Study Human Neural Development and Pathogenesis of Brain Diseases

Thiberge, C., Pou, M. L., Vitrac, A., Maskos, U., & Cloëz-Tayarani, I. (2022) · Neuromethods · doi:10.1007/978-1-0716-2569-9_8 · Cited by 3 · see citing works

Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex developmentPreprint

Graffunder, A. S., Bresser, A. A. J., Vallone, V. B. F., Megges, M., Stachelscheid, H., Kühnen, P., & Opitz, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.16.567497 · Cited by 3 · see citing works

Neocortical neurogenesis: a proneural gene perspective

Vasan, L., Moffat, A., Mattar, P. A., & Schuurmans, C. (2025) · FEBS Journal · doi:10.1111/febs.70158 · Cited by 2 · see citing works

Focal DEPDC5 loss without disruption to cerebral cortical neuron migration recapitulates DEPDC5-related focal epilepsy

Groff, K. J., Liang, Y.-N., Morici, C., Modasia, J. B., Mehendale, L., Gupta, N., D’Amore, A., Choe, Y., Hameed, M. Q., Rotenberg, A., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.181544 · Cited by 2 · see citing works

Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro

Kuc, C., Brott, J., Thorpe, H. H. A., Smart, A. N., & Vessey, J. P. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147700 · Cited by 2 · see citing works

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue

Raïs, C., Santos, D. G., Sansone, G., Blanchard, S., Bourgeois, J., Jagla, B., Saudemont, B., Schlick, L., Pons, S., & Maskos, U. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1259712 · Cited by 2 · see citing works

Three-Dimensional Models for Studying Neurodegenerative and Neurodevelopmental Diseases

Tsaridou, S., Skamnelou, M., Iliadou, M., Lokka, G., Parlapani, E., Mougkogianni, M., Danalatos, R.-I., Kanellou, A., Chlorogiannis, D., Kyrousi, C., et al. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-32633-3_6 · Cited by 3 · see citing works

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signalling to promote expansion of cortical progenitorsPreprint

Heurck, R. V., Wojno, M., Suzuki, I., Velez-Bravo, F. D., Bonnefont, J., Erkol, E., Nguyen, D. T., Herpoel, A., Bilheu, A., Ledent, C. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.17.142976 · Cited by 2 · see citing works

Temporal regulation of progenitor lineage progression and output by NFIs underlying human neocortical malformation

Zhang, Q., Yuan, G., Albizzati, E., Yang, J., Zhao, Z., Yu, X., Chang, X., Lee, C. H., Du, H., Lao, Z., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.021 · Cited by 1 · see citing works

Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders

Chang, X., Gu, M., & Tchieu, J. H. (2022) · Cells · doi:10.3390/cells11030460 · Cited by 1 · see citing works

In preprints: releasing the brakes on neuronal maturation

Rayón, T., & van den Ameele, J. (2022) · Development · doi:10.1242/dev.201477 · Cited by 1 · see citing works

The Molecular Landscape of the Developing Human Central Nervous System

Zhu, Y., Silbereis, J. C., Pochareddy, S., Li, M., & Šestan, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00013-5 · Cited by 1 · see citing works

Pluripotent Stem Cell Based Cultures to Study Key Aspects of Human Cerebral Cortex Development

Ehsaei, Z., Collo, G., & Taylor, V. (2018) · Institutional Research Information System (Università degli Studi di Brescia) · doi:10.4172/neuropsychiatry.1000511 · Cited by 1 · see citing works

Transplanted Human Induced Pluripotent Stem Cell-Derived Neurons Wire and Fire with Balanced Excitation–Inhibition in Rat Cortex

Carney, R. S. E. (2020) · eNeuro · doi:10.1523/eneuro.0041-20.2020 · Cited by 1 · see citing works

Temporal scaling in developmental gene networks by epigenetic timing controlPreprint

Nguyen, P. H., Pease, N. A., Ng, K. K. H., Irwin, B., & Kueh, H. Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/752170 · Cited by 1 · see citing works

Microenvironmental regulation of neural stem cell differentiation

Karaca, E. (2014) · Figshare

Migration Guidance of Human iPSC-derived Neurons by a Two-dimensional Patterning

Iida, S., Shimba, K., Tanaka, Y., Sakai, K., Kotani, K., & Jimbo, Y. (2016) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.136.1268

Lineages and molecular heterogeneity in the developing nervous system

Manno, G. L. (2018) · Figshare

Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity

Anderson, S., & Vanderhaeghen, P. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.012 · Cited by 40 · see citing works

From Human Pluripotent Stem Cells to Cortical Circuits

Astick, M., & Vanderhaeghen, P. (2018) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.011 · Cited by 34 · see citing works

Generation of cortical neurons from pluripotent stem cells

Vanderhaeghen, P. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59544-7.00009-3 · Cited by 5 · see citing works

ISDN2012_0276: From pluripotent stem cells to cortical circuits

Vanderhaeghen, P. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.10.098

From human pluripotent stem cells to cerebral cortical neurons

Deleanu, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822230-0.00013-2