Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity
Open accessAbstract
The cerebral cortex contains dozens of neuronal subtypes grouped in specific layers and areas. Recent studies have revealed how embryonic and induced pluripotent stem cells (PSC) can differentiate into a wide diversity of cortical neurons in vitro, while recapitulating many of the temporal and spatial features that characterize corticogenesis. PSC-derived neurons can integrate into the brain following in vivo transplantation and display patterns of morphology and connectivity specific of cortical neurons. PSC-corticogenesis thus emerges as a robust model that provides new ways to link cortical development, evolution, and disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human PSC-derived pyramidal cortical neurons and interneurons transplanted in the mouse brain develop morphologically and synaptically within their host.
“Human PSC-derived pyramidal cortical neurons and interneurons transplanted in the mouse brain develop morphologically and synaptically within their host”
From Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits (2019) · cites this paper as Anderson and Vanderhaeghen, 2014
The Modeling temporal patterns of corticogenesis section (page not provided) reports that transplanted human PSC-derived pyramidal neurons develop complex dendrites, spines, and functional synaptic activity in mouse cortex, but only after prolonged maturation. For transplanted interneurons, it reports limited terminal differentiation even after six months; the synaptogenesis finding concerns co-culture with mouse neurons, not transplantation. The claim therefore overextends the evidence for interneurons developing synaptically within the host. (LLM, conf=0.87)
Experimental — accuracy not yet measuredXenotransplantation of human neurons into the mouse brain can provide a means to study human neuronal maturation under more physiologically realistic conditions.
“xenotransplantation of human neurons into the mouse brain, which can provide a means to study human neuronal maturation under more physiologically realistic conditions”
From Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits (2019) · cites this paper as Anderson and Vanderhaeghen, 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works
Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504 · see citing works
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P., & Kostović, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105108108 · Cited by 1,411 · see citing works
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works
Embryo-Derived Stem Cells: Of Mice and Men
Smith, A. G. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.435 · Cited by 1,263 · see citing works
Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999 · see citing works
The origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works
Self-citationDevelopment of the human cerebral cortex: Boulder Committee revisited
Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977 · see citing works
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863 · see citing works
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830 · see citing works
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. C., & Livesey, F. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3041 · Cited by 813 · see citing works
Directed differentiation of telencephalic precursors from embryonic stem cells
Watanabe, K., Kamiya, D., Nishiyama, A., Katayama, T., Nozaki, S., Kawasaki, H., Watanabe, Y., Mizuseki, K., & Sasai, Y. (2005) · Nature Neuroscience · doi:10.1038/nn1402 · Cited by 784 · see citing works
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2008 · Cited by 738 · see citing works
Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
Yamanaka, S. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.012 · Cited by 737 · see citing works
Patterning and plasticity of the cerebral cortex
Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677 · see citing works
Kirkeby, A., Grealish, S., Wolf, D. A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O., & Parmar, M. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.009 · Cited by 662 · see citing works
An intrinsic mechanism of corticogenesis from embryonic stem cells
Gaspard, N., Bouschet, T., Hourez, R., Dimidschstein, J., Naeije, G., van den Ameele, J., Espuny-Camacho, I., Herpoel, A., Passante, L., Schiffmann, S. N., et al. (2008) · Nature · doi:10.1038/nature07287 · Cited by 641 · see citing works
Self-citationThe timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
Shen, Q., Wang, Y., Dimos, J. T., Fasano, C. A., Phoenix, T. N., Lemischka, I. R., Ivanova, N. B., Stifani, S., Morrisey, E. E., & Temple, S. (2006) · Nature Neuroscience · doi:10.1038/nn1694 · Cited by 625 · see citing works
Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works
Self-citationUsing iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
Paşca, S. P., Portmann, T., Voineagu, I., Yazawa, M., Shcheglovitov, A., Paşca, A. M., Cord, B., Palmer, T. D., Chikahisa, S., Nishino, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2576 · Cited by 585 · see citing works
Espuny-Camacho, I., Michelsen, K. A., Gall, D., Linaro, D., Hasche, A., Bonnefont, J., Bali, C., Orduz, D., Bilheu, A., Herpoel, A., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.011 · Cited by 568 · see citing works
Self-citationThe Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity
DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00029 · Cited by 527 · see citing works
Modeling human cortical development in vitro using induced pluripotent stem cells
Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., Horvath, T. L., & Vaccarino, F. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202944109 · Cited by 526 · see citing works
Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D. L., Arnold, C. M., Chen, Y.-J. J., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.005 · Cited by 513 · see citing works
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients
Shcheglovitov, A., Shcheglovitova, O., Yazawa, M., Portmann, T., Shu, R., Sebastiano, V., Krawisz, A., Froehlich, W., Bernstein, J. A., Hallmayer, J. F., et al. (2013) · Nature · doi:10.1038/nature12618 · Cited by 470 · see citing works
Betizeau, M., Cortay, V., Patti, D., Pfister, S., Gautier, E., Bellemin-Ménard, A., Afanassieff, M., Huissoud, C., Douglas, R. J., Kennedy, H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.032 · Cited by 462 · see citing works
Early Steps in the Development of the Forebrain
Wilson, S. W., & Houart, C. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00027-9 · Cited by 460 · see citing works
The genetics of early telencephalon patterning: some assembly required
Hébert, J. M., & Fishell, G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2463 · Cited by 377 · see citing works
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Hansen, D. V., Lui, J. H., Flandin, P., Yoshikawa, K., Rubenstein, J. L., Alvarez-Buylla, A., & Kriegstein, A. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3541 · Cited by 328 · see citing works
Subcortical origins of human and monkey neocortical interneurons
Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3536 · Cited by 322 · see citing works
G1 Phase Regulation, Area-Specific Cell Cycle Control, and Cytoarchitectonics in the Primate Cortex
Lukaszewicz, A., Savatier, P., Cortay, V., Giroud, P., Huissoud, C., Berland, M., Kennedy, H., & Dehay, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.032 · Cited by 315 · see citing works
The human brain in a dish: The promise of iPSC-derived neurons
Dolmetsch, R., & Geschwind, D. (2011) · Cell · doi:10.1016/j.cell.2011.05.034 · Cited by 313 · see citing works
Li, X.-J., Zhang, X., Johnson, M. A., Wang, Z.-B., LaVaute, T. M., & Zhang, S. (2009) · Development · doi:10.1242/dev.036624 · Cited by 312 · see citing works
A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome
Shi, Y., Kirwan, P., Smith, J., MacLean, G., Orkin, S. H., & Livesey, F. J. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003771 · Cited by 310 · see citing works
Li, Y., Wang, H., Muffat, J., Cheng, A. W., Orlando, D. A., Lovén, J., Kwok, S., Feldman, D., Bateup, H. S., Gao, Q., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.001 · Cited by 305 · see citing works
Liu, Y., Weick, J. P., Liu, H., Krencik, R., Zhang, X., Ma, L., Zhou, G., Ayala, M., & Zhang, S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2565 · Cited by 276 · see citing works
Making bigger brains–the evolution of neural-progenitor-cell division
Fish, J. L., Dehay, C., Kennedy, H., & Huttner, W. B. (2008) · Journal of Cell Science · doi:10.1242/jcs.023465 · Cited by 274 · see citing works
Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation
Wataya, T., Ando, S., Muguruma, K., Ikeda, H. O., Watanabe, K., Eiraku, M., Kawada, M., Takahashi, J. B., Hashimoto, N., & Sasai, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803078105 · Cited by 269 · see citing works
Krey, J. F., Pașca, S. P., Shcheglovitov, A., Yazawa, M., Schwemberger, R., Rasmusson, R. L., & Dolmetsch, R. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3307 · Cited by 252 · see citing works
Genetic regulation of arealization of the neocortex
O’Leary, D. D. M., & Sahara, S. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.011 · Cited by 219 · see citing works
Kelava, I., Reillo, I., Murayama, A. Y., Kalinka, A. T., Stenzel, D., Tomančák, P., Matsuzaki, F., Lebrand, C., Sasaki, E., Schwamborn, J. C., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr301 · Cited by 212 · see citing works
Opportunities and challenges of pluripotent stem cell neurodegenerative disease models
Sandoe, J., & Eggan, K. (2013) · Nature Neuroscience · doi:10.1038/nn.3425 · Cited by 209 · see citing works
Danjo, T., Eiraku, M., Muguruma, K., Watanabe, K., Kawada, M., Yanagawa, Y., Rubenstein, J. L. R., & Sasai, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5128-10.2011 · Cited by 179 · see citing works
Reillo, I., & Borrell, V. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr284 · Cited by 177 · see citing works
Bissonnette, C. J., Lyass, L., Bhattacharyya, B. J., Belmadani, A. A., Miller, R. J., & Kessler, J. A. (2011) · Stem Cells · doi:10.1002/stem.626 · Cited by 174 · see citing works
García‐Moreno, F., Vasistha, N. A., Trévia, N., Bourne, J. A., & Molnár, Z. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr312 · Cited by 154 · see citing works
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
Tiberi, L., van den Ameele, J., Dimidschstein, J., Piccirilli, J., Gall, D., Herpoel, A., Bilheu, A., Bonnefont, J., Iacovino, M., Kyba, M., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3264 · Cited by 132 · see citing works
Self-citationGoulburn, A. L., Alden, D., Davis, R. P., Micallef, S. J., Ng, E., Yu, Q. C., Lim, S. M., Soh, C.-L., Elliott, D. A., Hatzistavrou, T., et al. (2011) · Stem Cells · doi:10.1002/stem.587 · Cited by 103 · see citing works
Self-citationGermain, N. D., Banda, E. C., Becker, S., Naegele, J. R., & Grabel, L. B. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0264 · Cited by 57 · see citing works
Early Commitment of Embryonic Neocortical Cells to Develop Area-specific Thalamic Connections
Gaillard, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.5.443 · Cited by 38 · see citing works
Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid
Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. G., & Nakashima, K. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.09.012 · Cited by 37 · see citing works
Laminar fate specification in the cerebral cortex
Gaspard, N., & Vanderhaeghen, P. (2011) · F1000 Biology Reports · doi:10.3410/b3-6 · Cited by 36 · see citing works
Self-citationThe positional identity of mouse ES cell-generated neurons is affected by BMP signaling
Bertacchi, M., Pandolfini, L., Murenu, E., Viegi, A., Capsoni, S., Cellerino, A., Messina, A., Casarosa, S., & Cremisi, F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1182-3 · Cited by 29 · see citing works
Stage of specification of the spinal cord and tectal projections from cortical grafts
Pinaudeau-Nasarre, C., Gaillard, A., & Roger, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00148.x · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Fischer, I., Dulin, J. N., & Lane, M. A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0314-2 · Cited by 297 · see citing works
Linaro, D., Vermaercke, B., Iwata, R., Ramaswamy, A., Davis, B. A., Boubakar, L., Libé-Philippot, B., Bilheu, A., Bruyne, L. D., Gall, D., et al. (2019) · doi:10.1101/626218 · Cited by 210 · see citing works
“We and others previously reported a prolonged timeline of morphological development for transplanted human cortical neurons that was proposed to be in line with human cortical neoteny (Anderson and Vanderhaeghen, 2014; Espuny-Camacho et al., 2013; Maroof et al., 2013; Nicholas et al., 2013).”
BackgroundSelf-citationMichelsen, K. A., Acosta-Verdugo, S., Benoit-Marand, M., Espuny-Camacho, I., Gaspard, N., Saha, B., Gaillard, A., & Vanderhaeghen, P. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.001 · Cited by 138 · see citing works
Self-citationIs this a brain which I see before me? Modeling human neural development with pluripotent stem cells
Suzuki, I. K., & Vanderhaeghen, P. (2015) · Development · doi:10.1242/dev.120568 · Cited by 110 · see citing works
Self-citationEffects of antenatal glucocorticoids on the developing brain
Carson, R. A., Monaghan, A. P., DeFranco, D. B., & Rudine, A. C. (2016) · Steroids · doi:10.1016/j.steroids.2016.05.012 · Cited by 106 · see citing works
Espuny-Camacho, I., Michelsen, K. A., Linaro, D., Bilheu, A., Acosta-Verdugo, S., Herpoel, A., Giugliano, M., Gaillard, A., & Vanderhaeghen, P. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.094 · Cited by 88 · see citing works
Self-citationIdentification of FMR1-regulated molecular networks in human neurodevelopmentPreprint
Li, M., Shin, J., Risgaard, R. D., Parries, M., Wang, J., Chasman, D. A., Liu, S., Roy, S., Bhattacharyya, A., & Zhao, X. (2020) · Genome Research · doi:10.1101/gr.251405.119 · Cited by 71 · see citing works
Germain, N. D., Banda, E. C., Becker, S., Naegele, J. R., & Grabel, L. B. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0264 · Cited by 57 · see citing works
Building brains in a dish: Prospects for growing cerebral organoids from stem cells
Mason, J. O., & Price, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.048 · Cited by 54 · see citing works
García‐León, J. A., Cabrera‐Socorro, A., Eggermont, K., Swijsen, A., Terryn, J., Fazal, R., Nami, F., Ordovás, L., Quiles‐Jiménez, A., Lluı́s, F., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.05.007 · Cited by 50 · see citing works
Vidal, G. W. V., Rynes, M. L., Kelliher, Z., & Goodwin, S. J. (2016) · Scientifica · doi:10.1155/2016/8956432 · Cited by 50 · see citing works
Anderson, N. C., Chen, P.-F., Meganathan, K., Saber, W. A., Petersen, A. J., Bhattacharyya, A., Kroll, K. L., & Şahin, M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.03.025 · Cited by 47 · see citing works
Hernández, H. G., Sandoval-Hernández, A. G., Garrido‐Gil, P., Labandeira-García, J. L., Zelaya, M. V., Bayón, G. F., Fernández, A. F., Fraga, M. F., Arboleda, G., & Arboleda, H. (2018) · Epigenomics · doi:10.2217/epi-2017-0160 · Cited by 36 · see citing works
Cerebral Organoids as an Experimental Platform for Human Neurogenomics
Nowakowski, T. J., & Salama, S. R. (2022) · Cells · doi:10.3390/cells11182803 · Cited by 26 · see citing works
Ben‐Reuven, L., & Reiner, O. (2016) · Development Growth & Differentiation · doi:10.1111/dgd.12280 · Cited by 26 · see citing works
Clair, D. S., & Johnstone, M. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0037 · Cited by 24 · see citing works
Worms on the spectrum - C. elegans models in autism research
Schmeißer, K., & Parker, J. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.007 · Cited by 23 · see citing works
New genes for accurate normalization of qRT-PCR results in study of iPS and iPS-derived cells
Artyuhov, A., Dashinimaev, E. B., Tsvetkov, V. O., Bolshakov, A. P., Коновалова, Е. В., Kolbaev, S. N., Vorotelyak, E. A., & Vasiliev, A. V. (2017) · Gene · doi:10.1016/j.gene.2017.05.045 · Cited by 20 · see citing works
Efficient Generation of Corticofugal Projection Neurons from Human Embryonic Stem Cells
Zhu, X., Ai, Z., Hu, X., & Li, T. (2016) · Scientific Reports · doi:10.1038/srep28572 · Cited by 16 · see citing works
Lactate promotes H3K18 lactylation in human neuroectoderm differentiation
Wu, Y., Wang, Y., Dong, Y., Sun, L. V., & Zheng, Y. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05510-x · Cited by 15 · see citing works
Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons
Baldassari, S., Cervetto, C., Amato, S., Fruscione, F., Balagura, G., Pelassa, S., Musante, I., Iacomino, M., Traverso, M., Corradi, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810545 · Cited by 10 · see citing works
Gradient biomimetic platforms for neurogenesis studies
Havins, L., Capel, A. J., Christie, S. D. R., Lewis, M. P., & Roach, P. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac4639 · Cited by 8 · see citing works
Wei, N., Quan, Z.-F., Tang, H., & Zhu, J. (2017) · Stem Cells International · doi:10.1155/2017/5682354 · Cited by 7 · see citing works
Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells.
Ma, M., Ge, J.-Y., Nie, Y.-Z., Li, Y.-M., & Zheng, Y.-W. (2024) · Frontiers in Bioscience · doi:10.31083/j.fbl2901034 · Cited by 5 · see citing works
Stem Cells to Inform the Neurobiology of Mental Illness
Johnstone, M., Hillary, R. F., & Clair, D. S. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_57 · Cited by 5 · see citing works
Aqueous cigarette tar extracts disrupt corticogenesis from human embryonic stem cells in vitro
Begum, A. N., Aguilar, J. S., & Hong, Y. (2017) · Environmental Research · doi:10.1016/j.envres.2017.06.012 · Cited by 4 · see citing works
Nganou, G., Silva, C. G., Gladwyn-Ng, I. E., Engel, D., Coumans, B., Delgado‐Escueta, A. V., Tanaka, M., Nguyen, L., Grisar, T. M., de Nijs, L., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00234 · Cited by 4 · see citing works
Ni, P., Fan, L., Jiang, Y., Zhou, C., & Chung, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1336085 · Cited by 4 · see citing works
LHX2 regulates dendritic morphogenesis in layer II/III neurons of the neocortex
Bose, M., Ravindran, S., Kumari, S., Srivastava, A., Iyer, A., Vedak, B., Talwar, I., Narayanan, R., & Tole, S. (2025) · Science Advances · doi:10.1126/sciadv.ado1384 · Cited by 3 · see citing works
Vers une régénération induite du système nerveux
Heinrich, C., & Rouaux, C. (2015) · médecine/sciences · doi:10.1051/medsci/20153101011 · Cited by 2 · see citing works
Babović, I. R., Sparić, R., Plešinac, S., Kocijancic, D., Plešinac, J., Akšam, S. S., Plešinac, V., Pecorella, G., & Tinelli, A. (2024) · Diseases · doi:10.3390/diseases12120336 · Cited by 1 · see citing works
Human iPSC Models: A Platform for Investigating Neurodevelopmental Diseases
McKinney, C. E. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000122
Goodwin, S. J. (2015) · PubMed · Cited by 1 · see citing works
Muguruma, K. (2017) · Springer eBooks · doi:10.1007/978-981-10-3768-9_2 · Cited by 1 · see citing works
Carney, R. S. E. (2020) · eNeuro · doi:10.1523/eneuro.0041-20.2020 · Cited by 1 · see citing works
Bose, M., Ravindran, S., Kumari, S., Srivastava, A., Iyer, A., Vedak, B., Talwar, I., Narayanan, R., & Tole, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.30.577728 · Cited by 1 · see citing works
Human iPSC Models: A Platform for Investigating Neurodevelopmental
McKinney, D., & Brown, S. (2014)
Dean, B. J., Gamse, J. T., & Wu, S.-Y. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/261834
Babović, I. R., Dotlić, J., Sparić, R., Andjić, M., Bila, J. S., Micić, J., Jovandarić, M. Z., Plešinac, V., Plešinac, J., & Orlić, N. K. (2023) · Medicinska istrazivanja · doi:10.5937/medi56-44211
Staufen2 modulates the temporal dynamics of human neurogenesis in vitroPreprint
Ganesh, A. J., Moya, S. M. F., Gutiérrez-Franco, A., Ferreira, N. C., Tur-Guasch, R., Romero–Moya, D., Mularoni, L., Giorgetti, A., Piwecka, M., Rybak‐Wolf, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.02.679988
- Authors
- Anderson, S., & Vanderhaeghen, P.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Université Libre de Bruxelles (BE)
- Corresponding author
- Anderson, Stewart
- Vanderhaeghen, Pierre
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 27
- Pages
- 151-157
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC4386058
- OpenAlex
- W1969687514
- Cited by
- 40
- References
- 59
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Lirias (submittedVersion)
- Funders
- Belgian FNRS
- Belgian Queen Elizabeth Medical Foundation
- Interuniversity Attraction Poles Programme
- WELBIO
- Programme d’Excellence CIBLES of the Walloon Region
- Fondations Clerdent and de Spoelbergh
- Fondation ULB
- National Institutes of Mental Health (R01 MH066912, K02 MH070031)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- cortical neurogenesis, pluripotent stem cells, induced pluripotent stem cells, embryonic stem cells, cortical neurons, cortical development, in vivo transplantation, neural integration, cortical evolution, brain disease model
- MeSH terms
- Animals, Cerebral Cortex, Humans, Neurogenesis, Induced Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
