Bachstetter, Adam D.

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 755

CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity

Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 624

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

Bachstetter, A. D., Morganti, J. M., Jernberg, J., Schlunk, A., Mitchell, S. H., Brewster, K. W., Hudson, C. E., Cole, M. J., Harrison, J. K., Bickford, P. C., et al. (2011) · Neurobiology of Aging

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 364

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

Furman, J. L., Sama, D. M., Gant, J. C., Beckett, T. L., Murphy, M. P., Bachstetter, A. D., Van Eldik, L. J., & Norris, C. M. (2012) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 313

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

Bachstetter, A. D., Xing, B., de Almeida, L., Dimayuga, E. R., Watterson, D. M., & Van Eldik, L. J. (2011) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 282

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

Bachstetter, A. D., Van Eldik, L. J., Schmitt, F. A., Neltner, J. H., Ighodaro, E. T., Webster, S. J., Patel, E., Abner, E. L., Kryscio, R. J., & Nelson, P. T. (2015) · Acta Neuropathologica Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 258

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson’s disease

Pabon, M. M., Bachstetter, A. D., Hudson, C. E., Gemma, C., & Bickford, P. C. (2011) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 241

Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis

Diamond, D. M., Campbell, A. M., Park, C. R., Woodson, J. C., Conrad, C. D., Bachstetter, A. D., & Mervis, R. F. (2006) · Hippocampus

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 213

Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain

Shahidehpour, R. K., Higdon, R. E., Crawford, N. G., Neltner, J. H., Ighodaro, E. T., Patel, E., Price, D., Nelson, P. T., & Bachstetter, A. D. (2021) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 173

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

Yang, D., Kim, K. H., Phimister, A., Bachstetter, A. D., Ward, T. R., Stackman, R. W., Mervis, R. F., Wisniewski, A. B., Klein, S. L., Kodavanti, P. R. S., et al. (2009) · Environmental Health Perspectives

Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Cited by 166

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 126

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury

Febinger, H. Y., Thomasy, H. E., Pavlova, M. N., Ringgold, K. M., Barf, P. R., George, A. M., Grillo, J. N., Bachstetter, A. D., Garcia, J. A., Cardona, A. E., et al. (2015) · Journal of Neuroinflammation

Traumatic Brain Injury and Neurovascular DisturbancesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 110

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

Xing, B., Bachstetter, A. D., & Van Eldik, L. J. (2011) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 101

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

Roy, S. M., Grum-Tokars, V. L., Schavocky, J. P., Saeed, F., Staniszewski, A., Teich, A. F., Arancio, O., Bachstetter, A. D., Webster, S. J., Van Eldik, L. J., et al. (2015) · ACS Chemical Neuroscience

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 99

Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

Ighodaro, E. T., Abner, E. L., Fardo, D. W., Lin, A.-L., Katsumata, Y., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Neltner, J. H., Monsell, S. E., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism

Dementia and Cognitive Impairment ResearchCerebrovascular and genetic disorders

Cited by 98

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

Webster, S. J., Van Eldik, L. J., Watterson, D. M., & Bachstetter, A. D. (2015) · The Journal of Neuroscience

Traumatic Brain Injury and Neurovascular DisturbancesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 80

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Watterson, D. M., Grum-Tokars, V. L., Roy, S. M., Schavocky, J. P., Bradaric, B. D., Bachstetter, A. D., Xing, B., Dimayuga, E., Saeed, F., Zhang, H., et al. (2013) · PLoS ONE

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 80

Spirulina Promotes Stem Cell Genesis and Protects against LPS Induced Declines in Neural Stem Cell Proliferation

Bachstetter, A. D., Jernberg, J., Schlunk, A., Vila, J. L., Hudson, C., Cole, M. J., Shytle, R. D., Tan, J., Sanberg, P. R., Sanberg, C. D., et al. (2010) · PLoS ONE

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 71

A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism

Lyons, D. N., Vekaria, H., Macheda, T., Bakshi, V., Powell, D. K., Gold, B. T., Lin, A.-L., Sullivan, P. G., & Bachstetter, A. D. (2018) · Journal of Neurotrauma

Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular Disturbances

Cited by 55

The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review

Bachstetter, A. D., Morganti, J. M., Bodnar, C. N., Webster, S. J., Higgins, E. K., Roberts, K. N., Snider, H., Meier, S. E., Nation, G. K., Goulding, D. S., et al. (2020) · Experimental Neurology

Traumatic Brain Injury ResearchAlzheimer's disease research and treatments

Cited by 29

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

Bachstetter, A. D., Watterson, D. M., & Van Eldik, L. J. (2014) · Journal of Neuroimmune Pharmacology

Neuroinflammation and Neurodegeneration MechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 13