Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis
Abstract
We have studied the influence of predator stress (30 min of cat exposure) on long-term (24 h) spatial memory and the density of spines in basilar dendrites of CA1 neurons. Predator stress occurred either immediately before water maze training (Stress Pre-Training) or before the 24 h memory test (Stress Pre-Retrieval). The Control (nonstress) group exhibited excellent long-term spatial memory and a robust increase in the density of stubby, but not mushroom, shaped spines. The Stress Pre-Training group had impaired long-term memory and did not exhibit any changes in spine density. The Stress Pre-Retrieval group was also impaired in long-term memory performance, but this group exhibited an increase in the density of stubby, but not mushroom, shaped spines, which was indistinguishable from the control group. These findings indicate that: (1) A single day of water maze training under control conditions produced intact long-term memory and an increase in the density of stubby spines in CA1; (2) Stress before training interfered with the consolidation of information into long-term memory and suppressed the training-induced increase in spine density; and (3) Stress immediately before the 24 h memory test trial impaired the retrieval of the stored memory, but did not reverse the training-induced increase in CA1 spine density. Overall, this work provides evidence of structural plasticity in dendrites of CA1 neurons which may be involved in the consolidation process, and how spinogenesis and memory are modulated by stress.
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30 minutes of pretraining cat exposure suppressed the learning-induced increase in dendritic spine density in CA1.
“Second, we have found that 30 minutes of pretraining cat exposure suppressed the learning-induced increase in dendritic spine density in CA1 (Diamond et al. [137]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [137]
30 minutes of cat exposure suppressed molecular and structural measures of plasticity in the hippocampus.
“it also suppressed molecular (Sandi et al. [136]) and structural (Diamond et al. [137]) measures of plasticity in the hippocampus.”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [137]
Stress can influence the number of excitatory synapses on dendritic spines already within hours in brain regions including the hippocampus.
“Stress has been shown to influence the number of excitatory synapses on dendritic spines already within hours26,40 in brain regions including the hippocampus.34,41,42”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [41]
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- Authors
- Diamond, D. M., Campbell, A. M., Park, C. R., Woodson, J. C., Conrad, C. D., Bachstetter, A. D., & Mervis, R. F.
- Affiliations
- United States Department of Veterans Affairs (US)
- University of South Florida (US)
- University of Tampa (US)
- Arizona State University (US)
- Corresponding author
- Diamond, David M.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2006
- Volume
- 16
- Issue
- 7
- Pages
- 571-576
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W1980064922
- Cited by
- 213
- References
- 41
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 13 · 2016: 12 · 2015: 13 · 2014: 14 · 2013: 22 · 2012: 13
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Funders
- National Institute of Mental Health (MH64727, R01MH064727)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- predator stress, long-term spatial memory, memory consolidation, memory retrieval, hippocampal CA1, dendritic spine density, spinogenesis, structural plasticity, stress and memory
- MeSH terms
- Amnesia, Animals, Cats, Hippocampus, Male, Memory, Neuronal Plasticity, Predatory Behavior, Space Perception, Stress, Psychological, Rats, Sprague-Dawley, Maze Learning, Dendritic Spines, Rats
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