Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats
Open accessAbstract
Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic inflammation. Neuronal fractalkine (FKN), acting on CX(3)CR1, has been shown to suppress excessive microglia activation. We found that disruption in FKN/CX(3)CR1 signaling in young adult rodents decreased survival and proliferation of neural progenitor cells through IL-1β. Aged rats were found to have decreased levels of hippocampal FKN protein; moreover, interruption of CX(3)CR1 function in these animals did not affect neurogenesis. The age-related loss of FKN could be restored by exogenous FKN reversing the age-related decrease in hippocampal neurogenesis. There were no measureable changes in young animals by the addition of exogenous FKN. The results suggest that FKN/CX(3)CR1 signaling has a regulatory role in modulating hippocampal neurogenesis via mechanisms that involve indirect modification of the niche environment. As elevated neuroinflammation is associated with many age-related neurodegenerative diseases, enhancing FKN/CX(3)CR1 interactions could provide an alternative therapeutic approach to slow age-related neurodegeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic disruption of Cx3cr1 decreases the number of new neurons, supporting the importance of microglia-neuron communication in regulating adult neurogenesis.
“Genetic disruption of Cx3cr1 decreases the number of new neurons (Bachstetter et al., 2011) supporting the importance of microglia-neuron communication in regulating adult neurogenesis.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Bachstetter et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works
Control of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works
Aloisi, F. (2001) · Glia · doi:10.1002/glia.1106 · Cited by 1,281 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works
Self-citationDoublecortin expression levels in adult brain reflect neurogenesis
Couillard‐Després, S., Winner, B., Schaubeck, S., Aigner, R., Vroemen, M., Weidner, N., Bogdahn, U., Winkler, J., Kuhn, H. G., & Aigner, L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03813.x · Cited by 967 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Neuronal ‘On’ and ‘Off’ signals control microglia
Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787 · see citing works
Hundhausen, C., Misztela, D., Berkhout, T. A., BROADWAY, N. M., Säftig, P., Reiß, K., Hartmann, D., Fahrenholz, F., Postina, R., Matthews, V. B., et al. (2003) · Blood · doi:10.1182/blood-2002-12-3775 · Cited by 714 · see citing works
Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
Meucci, O., Fatatis, A., Simen, A. A., Bushell, T. J., Gray, P. W., & Miller, R. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14500 · Cited by 692 · see citing works
Rao, M. S. R., & Shetty, A. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03123.x · Cited by 654 · see citing works
Garton, K. J., Gough, P. J., Blobel, C., Murphy, G., Greaves, D. R., Dempsey, P. J., & Raines, E. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106434200 · Cited by 639 · see citing works
Combadière, C., Feumi, C., Raoul, W., Keller, N., Rodéro, M., Pézard, A., Lavalette, S., Houssier, M., Jonet, L., Picard, E., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31692 · Cited by 618 · cited 2× · see citing works
“, 2003) and increased risk of age-related macular degeneration (Combadiere et al., 2007; Tuo et al., 2004).”
BackgroundIosif, R. E., Ekdahl, C. T., Ahlenius, H., Pronk, C. J., Bonde, S., Kokaia, Z., Jacobsen, S. E. W., & Lindvall, O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2723-06.2006 · Cited by 462 · see citing works
Expression of CX <sub>3</sub> CR1 chemokine receptors on neurons and their role in neuronal survival
Meucci, O., Fatatis, A., Simen, A. A., & Miller, R. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090017497 · Cited by 385 · see citing works
Early age-related changes in adult hippocampal neurogenesis in C57 mice
Abdallah, N. M. ‐. B., Slomianka, L., Vyssotski, A. L., & Lipp, H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.002 · Cited by 368 · see citing works
Production and neuroprotective functions of fractalkine in the central nervous system.
Mizuno, T., Kawanokuchi, J., Numata, K., & Suzumura, A. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02867-1 · Cited by 352 · see citing works
Milligan, E. D., Zapata, V., Chacur, M., Schoeniger, D., Biedenkapp, J. C., O’Connor, K., Verge, G. M., Chapman, G. A., Green, P., Foster, A. C., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03709.x · Cited by 289 · see citing works
McDermott, D. H., Fong, A. M., Yang, Q., Sechler, J. M. G., Cupples, L. A., Merrell, M. N., Wilson, P. W. F., D’Agostino, R. B., O’Donnell, C. J., Patel, D. D., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16790 · Cited by 281 · see citing works
Rao, M. S., Hattiangady, B., & Shetty, A. K. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00243.x · Cited by 241 · see citing works
Tuo, J., Smith, B. C., Bojanowski, C. M., Meleth, A. D., Gery, I., Csaky, K. G., Chew, E. Y., & Chan, C.-C. (2004) · The FASEB Journal · doi:10.1096/fj.04-1862fje · Cited by 215 · see citing works
Tong, N., Perry, S. W., Zhang, Q., James, H. J., Guo, H., Brooks, A. I., Bal, H., Kinnear, S. A., Fine, S. M., Epstein, L. G., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1333 · Cited by 183 · see citing works
Chemokines Promote Quiescence and Survival of Human Neural Progenitor Cells
Krathwohl, M. D., & Kaiser, J. L. (2004) · Stem Cells · doi:10.1634/stemcells.22-1-109 · Cited by 168 · see citing works
Targeted deletion of CX3CR1 reveals a role for fractalkine in cardiac allograft rejection
Haskell, C. A., Hancock, W. W., Salant, D. J., Gao, W., Csizmadia, V., Peters, W., Faia, K., Fituri, O. M., Rottman, J. B., & Charo, I. F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12976 · Cited by 167 · see citing works
Immune-based regulation of adult neurogenesis: Implications for learning and memory
Ziv, Y., & Schwartz, M. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.006 · Cited by 158 · see citing works
Generation and Analysis of Mice Lacking the Chemokine Fractalkine
Cook, D. N., Chen, S., Sullivan, L. M., Manfra, D. J., Wiekowski, M., Prosser, D. M., Vassileva, G., & Lira, S. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.3159-3165.2001 · Cited by 156 · see citing works
MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons
Fuller, A. D., & Eldik, L. J. V. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9118-2 · Cited by 155 · see citing works
Stem Cell Review Series: Role of neurogenesis in age‐related memory disorders
Drapeau, E., & Abrous, D. N. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00369.x · Cited by 136 · see citing works
Vega, C. J., & Peterson, D. A. (2005) · Nature Methods · doi:10.1038/nmeth741 · Cited by 128 · see citing works
Labrada, L., Liang, X. H., Zheng, W., Johnston, C., & Levine, B. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11688-11703.2002 · Cited by 126 · see citing works
Kim, T., Lim, H. K., Lee, J. Y., Kim, D., Park, S., Lee, C., & Lee, C. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.019 · Cited by 115 · see citing works
Ji, J. F., He, B. P., Dheen, S. T., & Tay, S. S. W. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.024 · Cited by 112 · see citing works
Lauro, C., Di Angelantonio, S., Cipriani, R., Sobrero, F., Antonilli, L., Brusadin, V., Ragozzino, D., & Limatola, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7590 · Cited by 110 · see citing works
Zujovic, V., Schussler, N., Jourdain, D., Duverger, D., & Taupin, V. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00259-4 · Cited by 102 · see citing works
Interleukin-1ß and Caspase-1: Players in the Regulation of Age-related Cognitive Dysfunction
Gemma, C., & Bickford, P. C. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.2.137 · Cited by 99 · see citing works
Self-citationPeripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain
Bachstetter, A. D., Pabon, M. M., Cole, M. J., Hudson, C. E., Sanberg, P. R., Willing, A. E., Bickford, P. C., & Gemma, C. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-22 · Cited by 95 · see citing works
Self-citationFractalkine: moving from chemotaxis to neuroprotection
Ré, D. B., & Przedborski, S. (2006) · Nature Neuroscience · doi:10.1038/nn0706-859 · Cited by 91 · see citing works
Endl, E., & Gerdes, J. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200003)182:3 · Cited by 89 · see citing works
Decreased Fractalkine and Increased IP-10 Expression in Aged Brain of APPswe Transgenic Mice
Duan, R., Yang, X., Chen, Z., Lu, M., Morris, C. M., Winblad, B. G., & Zhu, J. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9554-z · Cited by 82 · see citing works
Blockade of caspase‐1 increases neurogenesis in the aged hippocampus
Gemma, C., Bachstetter, A. D., Cole, M. J., Fister, M. C., Hudson, C., & Bickford, P. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05875.x · Cited by 73 · see citing works
Self-citationSpulber, S. D., Oprica, M., Bartfai, T., Winblad, B. G., & Schultzberg, M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06050.x · Cited by 54 · see citing works
Zujovic (2000) · doi:10.1002/(sici)1098-1136(20000215)29:4
Flagged first, then by citations
Cited by
Sorted by citations
Microglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works
Microglial signatures and their role in health and disease
Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046 · see citing works
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works
Microglial dysfunction in brain aging and Alzheimer's disease
Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635 · see citing works
CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3667-11.2011 · Cited by 624 · see citing works
Self-citationNorden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.028 · Cited by 413 · see citing works
Factors regulating microglia activation
Kierdorf, K., & Prinz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00044 · Cited by 360 · see citing works
Beumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212100 · Cited by 347 · see citing works
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Microglia, seen from the CX3CR1 angle
Wolf, Y., Yona, S., Kim, K.-W., & Jung, S. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00026 · Cited by 316 · see citing works
Chronic peripheral inflammation, hippocampal neurogenesis, and behavior
Chesnokova, V., Pechnick, R. N., & Wawrowsky, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.017 · Cited by 299 · see citing works
Microglial Dysregulation in Psychiatric Disease
Frick, L. R., Williams, K., & Pittenger, C. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/608654 · Cited by 299 · see citing works
Lee, M., Lee, Y., Song, J., Lee, J., & Chang, S.-Y. (2018) · Immune Network · doi:10.4110/in.2018.18.e5 · Cited by 260 · see citing works
“In rat, administration of recombinant CX3CL1 can result in reduction of neurodegenerative disease (39).”
BackgroundDeczkowska, A., Matcovitch-Natan, O., Tsitsou-Kampeli, A., Ben-Hamo, S., Dvir-Szternfeld, R., Spinrad, A., Singer, O., David, E., Winter, D. R., Smith, L. K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00769-0 · Cited by 260 · see citing works
Artegiani, B., Lyubimova, A., Muraro, M., van Es, J. H., van Oudenaarden, A., & Clevers, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.050 · Cited by 259 · see citing works
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson’s disease
Pabon, M. M., Bachstetter, A. D., Hudson, C. E., Gemma, C., & Bickford, P. C. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-9 · Cited by 241 · see citing works
Aging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246 · see citing works
Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging
Vukovic, J., Colditz, M. J., Blackmore, D. G., Ruitenberg, M. J., & Bartlett, P. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5925-11.2012 · Cited by 241 · see citing works
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236 · see citing works
Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.05.011 · Cited by 224 · see citing works
Modulating neurotoxicity through CX3CL1/CX3CR1 signaling
Limatola, C., & Ransohoff, R. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00229 · Cited by 210 · see citing works
Microglial immune checkpoint mechanisms
Deczkowska, A., Amit, I., & Schwartz, M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0145-x · Cited by 185 · see citing works
Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198 · see citing works
Effects of Microglia on Neurogenesis
Sato, K. (2015) · Glia · doi:10.1002/glia.22858 · Cited by 187 · see citing works
Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation
Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179 · see citing works
Kohman, R. A., DeYoung, E. K., Bhattacharya, T. K., Peterson, L. N., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.006 · Cited by 176 · see citing works
Systematic Review of the Neurobiological Relevance of Chemokines to Psychiatric Disorders
Stuart, M. J., Singhal, G., & Baune, B. T. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00357 · Cited by 163 · see citing works
Maggi, L. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00022 · Cited by 149 · see citing works
The Role of Immunosenescence in Neurodegenerative Diseases
Costantini, E., D’Angelo, C., & Reale, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/6039171 · Cited by 133 · see citing works
Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics
Madry, C., & Attwell, D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.637157 · Cited by 109 · see citing works
<i>Cx3cr1-</i> deficient microglia exhibit a premature aging transcriptome
Gyoneva, S., Hosur, R., Gosselin, D., Zhang, B., Ouyang, Z., Cotleur, A. C., Peterson, M., Allaire, N., Challa, R., Cullen, P., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900453 · Cited by 103 · see citing works
“In addition, lack of Cx3cr1 expression reduces adult neurogenesis in the HC and olfactory bulb, and impairs the integration of newborn neurons (Bachstetter et al, 2011; Rogers et al, 2011; Xiao et al, 2015; Sellner et al, 2016; Reshef et al, 2017).”
Role of Chemokines in the Development and Progression of Alzheimer’s Disease
Wojcieszak, J., Kuczyńska, K., & Zawilska, J. B. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02047-1 · Cited by 97 · see citing works
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
Amaya-Montoya, M., Pérez-Londoño, A., Guatibonza-García, V., Vargas-Villanueva, A., & Mendivil, C. O. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01287-0 · Cited by 82 · see citing works
Tang, M.-M., Lin, W.-J., Pan, Y.-Q., & Li, Y.-C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00255 · Cited by 73 · see citing works
“…expression level of CX3CL1 within the hippocampus compared to adults, and Frontiers in Cellular Neuroscience | www.frontiersin.org 11 August 2018 | Volume 12 | Article 255 restoring CX3CL1 level increases new cells in the granule cell layer (Bachstetter et al., 2011; Norden and Godbout, 2013).”
BackgroundFan, Q., He, W., Gayen, M., Benoit, M. R., Luo, X., Hu, X., & Yan, R. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1333-19.2019 · Cited by 58 · see citing works
Xu, M.-X., Yu, R., Shao, L.-F., Zhang, Y.-X., Ge, C.-X., Liu, X.-M., Wu, W.-Y., Li, J.-M., & Kong, L.-D. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.01.001 · Cited by 61 · see citing works
- Authors
- Bachstetter, A. D., Morganti, J. M., Jernberg, J., Schlunk, A., Mitchell, S. H., Brewster, K. W., Hudson, C. E., Cole, M. J., Harrison, J. K., Bickford, P. C., & Gemma, C.
- Affiliations
- University of South Florida (US)
- James A. Haley Veterans' Hospital (US)
- University of Florida (US)
- Corresponding author
- Gemma, Carmelina
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 32
- Issue
- 11
- Pages
- 2030-2044
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC2889032
- OpenAlex
- W2145384905
- Cited by
- 364
- References
- 46
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 16 · 2023: 15 · 2022: 25 · 2021: 22 · 2020: 28 · 2019: 32 · 2018: 22 · 2017: 31 · 2016: 32 · 2015: 16 · 2014: 34 · 2013: 21 · 2012: 22
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Amgen
- U.S. Forest Service
- National Institute on Aging (R21AG024165, P01AG004418, AG024165A, AG004418)
- National Institute of Allergy and Infectious Diseases (AI058256, R01AI058256)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- fractalkine, CX3CR1, hippocampal neurogenesis, microglial activation, neuroinflammation, neural progenitor cells, IL-1β, aging, age-related neurodegeneration
- MeSH terms
- CX3C Chemokine Receptor 1, Age Factors, Aging, Animals, Hippocampus, Neurons, Signal Transduction, Microglia, Receptors, Chemokine, Rats, Interleukin-1beta, Chemokine CX3CL1, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
